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Parkinson’s disease (PD) is the most com- mon cause of movement disorder and has a median age-of-onset of ~55 years. It presents with a classical triad of motor symptoms: akinesia, rigidity and tremor. Many patients also suffer from non-motor symptoms, including disturbances of autonomic func- tions and deterioration of cognition1. The aetiology and pathogenetic mechanisms that cause PD remain eni

https://www.wnc.lu.se/sites/wnc.lu.se/files/brundin_et_al_nature_rev_neurosci_2008.pdf - 2026-05-28

Aims/hypothesis. Conformation-dependent autoantibodies directed against GAD65 are markers of Type 1 diabetes. In this study we aimed to determine whether the substitution of GAD65 with GAD67 amino acids would affect the binding of conformation-dependent GAD65 autoantibodies. Methods. We used PCR-based site-directed mutagenesis to generate a series of mutated GAD65 cDNA constructs in which specific

Kan klimatkompensation handla om mer än klimatnytta? Klimatkompensation har varit på modet ett tag men är även ett omdiskuterat ämne där både moralen i ”att köpa sig fri” och risken för negativ påverkan på djur och natur har lyfts fram. Att ekologiska aspekter beaktas vid klimatkompensation anses av många företag och organisationer viktigt. Men vad innebär det i praktiken? Klimatkompensation ärCarbon offsetting is one strategy to tackle global climate change and decrease the level of greenhouse gases in the atmosphere. However, the strategy is debated and concerns are raised regarding negative impacts on the surrounding environment and biodiversity, the effectiveness and the morality of “buying the right to pollute”. The aim of this paper is to examine if ecological aspects are consider

I 23 kap. 6 § 1 st. BrB stadgas straffansvar för den som underlåter att i tid avslöja ett förestående eller pågående brott. Skyldigheten att avslöja brott gäller vissa utvalda allvarliga brott, som exempelvis mord, mordbrand och våldtäkt. Bestämmelsen används sällan i rättspraxis och det saknas för närvarande något prejudicerande avgörande gällande hur underlåtenhet att avslöja brott ska tillämpasFailure to reveal a crime is criminalized in Chapter 23, Section 6, first paragraph of The Swedish Penal Code. The obligation to reveal a crime does only apply to a few serious crimes, such as murder, arson and rape. Currently, a valid precedent from the supreme court regarding the interpretation of the provision does not exist. The provision is rarely applied by the courts of law. A possible expl

Thesis purpose: The purpose of this thesis is to determine how a technolo-gically enhanced shopping tool, synergizing eCRM tech-niques with personalized promotion at the point-of-sale, can increase customer loyalty by considering perceptions of current grocery retailer loyalty programs in Sweden. Methodology: An exploratory research was undertaken in the light of a qualitative method collecting pr

The Vaxholm conflict was initiated when the Swedish Trade Union for Construction Workers shut down a construction site in order to prevent a Latvian construction company to build a school after the two parties had failed to agree upon a collective agreement in compliance with Swedish regulations. An emotional public debate followed that resulted in a discussion of the proposal for the Services Dir

The aim was to study whether stimuli that cannot be detected consciously might nevertheless influence subject’s higher cognitive functions, and whether such an effect differs in individuals with different levels of state-trait anxiety, social desirability and “Repressor”. Participants (N = 56) listened to a classical piece of music in which subliminal messages were embedded. These messages could b

Two nickel(II) complexes, [Ni(L)(2)] (1) and [Ni-2(mu(1,1)-N-3)(2)(L)(2)(DMSO)(2)] (2) [where HL = 3-(methyl-amino)propyliminomethyl-4-bromophenol, a tridentate Schiff base], have been synthesized and characterized by elemental analysis, IR, UV-Vis and fluorescence spectroscopy and single-crystal X-ray diffraction studies. The deprotonated tridentate Schiff base occupies three coordination sites o

We investigate four different methods for background estimation in calcium imaging of the insect brain and evaluate their performance on six data sets consisting of data recorded from two sites in two species of moths. The calcium fluorescence decay curve outside the potential response is estimated using either a low-pass filter or constant, linear or polynomial regression, and is subsequently use

The cysteine proteases are enzymes found in every kingdom of life. Clan CA is the largest of the cysteine protease clans, with members all displaying a Cys/His/Asn(Asp) catalytic triad responsible for hydrolysing the peptide bond within the substrate. To regulate the activity of the proteases, another group of proteins act as natural inhibitors (cysteine protease inhibitors) and bind to the protea

Title: ABILITY > KNOWLEDGE - Can Learning Organizational Qualities be trained in the school system through Supplemental Instruction, and if so, how early? Issue of Thesis: The acceleration of the amount of knowledge that an organization in the 21st century needs to process is growing with exponential numbers. In order to survive, the organizations need to transform themselves into Learning Organi

Många personers yrke kräver noggrann rengöring av händer flera gånger dagligen, och det är tydligt att huden tar stryk av detta. En mjukgörande kräm som samtidigt innehåller alkohol för att döda bakterierna hade varit en välkommen lösning för dessa personer. Men för att veta om alkoholen kan påverka krämens stabilitet behöver man veta hur de separata komponenterna samspelar.For personnel working in areas where hand disinfection is important, skin irritation on hands is a large and real problem. A solution may be a hand cream, containing ethanol, with moisturizing properties by using a Pickering emulsion. However, the effect of ethanol on a Pickering emulsion is unknown. The objective of this work was to gain understanding of this by mapping the phase diagram of trigl

Semantic segmentation and object detection are nowadays dominated by methods operating on regions obtained as a result of a bottom-up grouping process (segmentation) but use feature extractors developed for recognition on fixed-form (e.g. rectangular) patches, with full images as a special case. This is most likely suboptimal. In this paper we focus on feature extraction and description over free-

The recent phenomenon of large-scale acquisition of land for a variety of investment purposes has raised deep concerns over the food security, livelihood and socio-economic development of communities in many regions of the developing world. This study set out to investigate the food security outcomes of land acquisitions in northern Sierra Leone. Using a mixture of quantitative and qualitative res

Collaboration between academia and industry is believed important for innovation: industry needs academic expertise and know-how and academics need empirical data, test beds and more. So what needs to be improved? A pilot study conducted for BillerudKorsnäs confirms findings in previous research: the main challenge to industry-academia collaboration is the lack of mutual understanding of each oth

Many modern office buildings have highly glazed facades. Their energy efficiency and indoor climate is, however, being questioned. Therefore more and more of these buildings are being built with double skin facades, which can provide: a thermal buffer zone, energy savings, wind protection with open windows, fire protection, aesthetics, solar preheating of ventilation air, sound protection, polluta