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Non-covalently molecularly imprinted polymers (MIPs) for beta(2)-amino acids were prepared for the first time. N-(2-chlorobenzyloxycarbonyl)-(R)-beta(2)-homophenylalanine (N-2-ClZ-(R)-beta(2)-HPhe)was imprinted with methacrylic acid (MAA) and/or 4-vinylpyridine (4-VPy) as the functional monomers, with ethylene glycol dimethacrylate ( EDMA) as the cross-linker. The MIPs made with different ratios o

We have studied the dynamics of water molecules in six crystal structures of four human cytochromes P450, 2A6, 2C8, 2C9, and 3A4, with molecular dynamics simulations. In the crystal structures, only a few water molecules are seen and the reported sizes of the active-site cavity vary a lot. In the simulations, the cavities are completely filled with water molecules, although with similar to 20% low

Membrane proteins play several important roles in a cell. Among these proteins are aquaporins (AQPs) and transient receptor potential (TRP) ion channels that mediate water transport, temperature and noxious chemical sensation, respectively. The function of some AQPs, for example the spinach isoform SoPIP2;1 is regulated by pH, phosphorylation and heavy metals such as mercury. However, the mechanis

PURPOSE: The aim of this study was to test a model proposing that the relationship between personality factors and women's quality of life (QoL) is mediated by degree of depression and the way in which every day activity and general health were appraised. Specifically, the paper addressed the mediating contribution of activity. METHODS: A sample of 488 women, 38 or 50 years old, filled out questio

Popular Abstract in English From the pure technological perspective (leaving the business aside), the design of electronic devices, such as mobile phones, is an extremely complex process often involving a large number of disciplines, from mastering complicated mathematical models to proficiency of physical and electrical properties of specific materials involved in the manufacturing. In order to oThe methodology behind this work has been to use the concept of algorithm-hardware co-design to achieve efficient solutions related to the digital front-end in mobile receivers. It has been shown that, by looking at algorithms and hardware architectures together, more efficient solutions can be found; i.e., efficient with respect to some design measure. In this thesis the main focus have been plac

Aims/hypothesis. Conformation-dependent autoantibodies directed against GAD65 are markers of Type 1 diabetes. In this study we aimed to determine whether the substitution of GAD65 with GAD67 amino acids would affect the binding of conformation-dependent GAD65 autoantibodies. Methods. We used PCR-based site-directed mutagenesis to generate a series of mutated GAD65 cDNA constructs in which specific

Both spring temperature and date of the first Starling Sturnus vulgaris egg were highly correlated between different study sites and weather stations in the southern half of Sweden. In southern Sweden, but not in northern Sweden, onset of breeding correlated strongly with spring temperature, particularly during the last ten days of April, the period that happens to coincide with the start of breed

Our understanding of the rises of animal and cancer multicellularity face the same conceptual hurdles: what makes the clade originate and what makes it diversify. Between the events of origination and diversification lies complex tissue organization that gave rise to novel functionality for organisms and, unfortunately, for malignant transformation in cells. Tissue specialization with distinctly s

Occupancy of cold habitats by evergreen species requires structural modification of photosynthetic organs for stress resistance and longevity. Such modifications have been described at interspecific level, while intraspecific variation has been underexplored. To identify structural and anatomical traits that may be adaptive in cold environments, we studied intraspecific variability of needles of S

Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a raredisease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment.This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-basedregistry data, (II) to evaluate tolerability and efficacy of lenalidomiMantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid

Recent Hubble Space Telescope observations of a large sample of globular clusters reveal that every cluster contains between 40 and 400 blue stragglers.The population does not correlate with either stellar collision rate (as would be expected if all blue stragglers were formed via collisions) or total mass (as would be expected if all blue stragglers were formed via the unhindered evolution of a s

Digital elevation models (DEMs) can be captured and analysed by various methods. Elevation capturing with RTK-GPS and airborne laser scanning is presented and evaluated in terms of height accuracy of raw data and interpolated DEMs for study sites in Sweden and Germany. Applications for precision agriculture are based on the connection of land surface and the movement of water in the landscape. Thr

Although the consequences of urbanization for the physiological health of animals are the focus of much active research, an overlooked aspect is how physiology could be indirectly modulated by the urban environment via changes in intraspecific behavioural interactions, particularly among gregarious species. Both urbanization and the establishment, as well as maintenance, of hierarchical rank posit

The topic of this thesis is the optimal control of transportation networks. The problem studied is a dynamical extension of a classical problem in economics, in which the objective is to distribute goods to maximize welfare, whilst satisfying constraints on production and consumption. The main contribution is to show that for a class of welfare functions and dynamics, the optimal control is highly

Advances in mobile and wireless technology have expanded the scope of electrodermal research. Since traditional electrodermal measurement sites are not always suitable for laboratory research and are rarely appropriate for ambulatory measurements, there is a need to explore and contrast alternate measurement locations. We evaluated bilateral electrodermal activity (EDA) from five measurement sites

Splicing and translation are two of the key steps of post-transcriptional regulation of gene expression. Their tight regulation is essential for development, whereas their deregulation is involved in cancer pathogenesis. Nevertheless, many of the molecular mechanisms controlling these processes are still unknown. Hence, the main aim of this thesis is to elucidate novel regulatory mechanisms that a

Försurning och övergödning utgör betydande hot mot världens ytvatten och svenska vatten är bland de mest utsatta. I den här studien har avrinningsområdet Storskogen analyserats för att undersöka sambandet mellan atmosfäriskt nedfall, hydrologi och ytvattenkemi. Med atmosfäriskt nedfall menas de luftburna föroreningar som landar på avrinningsområdet antingen för att de fångas upp av trädkronorna eWater chemistry alterations such as acidification and eutrophication represent major threats to the running waters of the world, and Swedish waters are among the most vulnerable. In this study the small forested catchment Storskogen, part of the SWETHRO monitoring network, was analysed to examine the links between deposition, catchment hydrological properties and surface water chemistry. Storskoge

Sveriges regering satte 2011 upp mål om att bli bäst på att utnyttja digitaliseringens möjligheter. Digitaliseringen av bygglovsprocessen har trots det gått långsamt. Bygglovsprocessen idag (2018) är en långsam, dyr och ineffektiv process. Möjligheten att söka bygglov med e-legitimation finns endast hos 30 procent av kommunerna och 60 procent har någon slags e-tjänst ansökan. Ansökningarna innebär

På nittiotalet såg lagstiftaren att en ökad arbetstakt ledde till mer riskfyllda arbetsplatser. Lagstiftaren ansåg att den ökade specialiseringen innebar att det inte fanns fullständiga kunskaper om vilka risker arbetarna utsattes för. För att öka tryggheten för arbetarna infördes arbetsmiljöbrotten i brottsbalken. Detta skulle leda till en ökad kunskap inom rättsväsendet. Lagstiftaren ville öka rIn the 1990’s, the legislative power witnessed an increased pace in the work environment, and consequently also an enhanced risk for occupational injuries. Moreover, further specialization had resulted in a lack of knowledge concerning the risks that the workers were exposed to in the workplace. With the intent of increasing the safety for workers in their occupations, violations of the Work Envir