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Enhancers are central regulators of cell-type-specific gene expression, yet direct functional mapping of active enhancer-promoter interactions in single cells remains technically challenging. DNA adenine methyltransferase (Dam)-based chromatin recording offers a strategy to mark genomic regions proximal to proteins associated with active transcription sites in vivo, including enhancer regions, and
The recycling of cured silicone elastomers addresses three critical challenges: reducing the energy-intensive production and demand for raw materials and improving waste management for synthetic and natural rubber materials. A significant obstacle is the strong crosslinks within the polymer network, which give these materials their unique properties but also make them non-biodegradable and difficu
The popularity of the Netflix series ‘Drive To Survive’ has almost doubled the amount of Formula 1 (F1) fans thanks to its great storytelling and compelling narratives about the drivers, teams, the rivalries between them and challenges they tackle. The first season aired in 2019 and it is estimated that more than 6.8 million people have watched the show. As a result, the F1 brand is stronger than
It is sometimes said that modern politics has lost track of ideology and vision - that personal charisma and expertise is rewarded more than firm beliefs and connections with an organised movement. In their book Technopopulism: the New Logic of Democratic Politics, Christopher J. Bickerton and Carlo Invernizzi Accetti go beyond such suspicions. Their main argument is that the organisational politi
This thesis explores the Swedish EdTech sector, specifically investigating the commercialization of Virtual Reality (VR) technology as an innovation. Conducted as a case study in collaboration with Edda Knowledge, it aims to address a research gap identified by several scholars who note that the research field of commercialization process and stakeholder theory has predominantly focused on expert
Architecture is always intrinsically tied to place. Regardless of how architects choose to interact with and study it, the context our buildings are meant to inhabit is an important piece of the puzzle. As the world is getting more interconnected and geographical constraints are getting less important to the architectural profession, I am interested in how the creative process changes when assumpt
Many songbird species that breed at northern latitudes migrate long distances each autumn, while others brave the cold winter. Long-distance migrants have physiological adaptations that allow them to rapidly gain weight at stopover sites during migration for optimal speed. There is some evidence from closely related species that birds with a longer migration distance deposit fuel faster. However,
The current COVID-19 pandemic has confused markets and economies, leading competition authorities around the world to consider how to apply competition law in these exceptional circumstances. Competition authorities have introduced tools that have not previously been used in competition law and have succeeded in providing companies with prompt advice in cases of extreme urgency. The COVID-19 crisi
This study explores the different psychological processes and psychological capital resources that help entrepreneurs sustain motivation to re-enter entrepreneurship after discontinuing a previous venture. While existing literature has focused intensely on the financial and social costs of business failure, minimal yet growing scholarly attention has focused on the psychological costs of failure a
In modern recruitment, organizations tend to face a persistent paradox: they must align candidates with existing cultural values while simultaneously promoting workforce diversity. This thesis investigates how HR professionals navigate the inherent tension between organizational fit and diversity within recruitment processes across multinational public and private organizations in Europe and South
The increasing global demand for sustainable energy has sparked interest in combining renewable technologies to leverage their synergies. This thesis presents a pre-feasibility study of a combined offshore wind and wave energy farm located off the coast of Galicia, Spain. In collaboration with Wavepiston, a Danish developer of wave energy converters (WECs), the study evaluates the integration of t
Climate change adaptation (CCA) has become a prominent topic as the global environment changes. Increased extreme weather events, changes in microclimates and local ecosystems necessitate a change in current production methods, particularly within the food industry. Aquaculture, which provides over 50% of the global seafood, is particularly vulnerable to climate change. That includes Norway, the w
At self-similarity the strain history is implicit in and deducible from the strain field at each instance of the loading process. This fact is taken advantage of in a FEM-technique which allows the load to be applied in one single step, only, even when the incremental theory of plastic flow has to be used. Two self-similar problems are solved. Firstly an analytically solvable anti-plane strain craAt self-similarity the strain history is implicit in and deducible from the strain field at each instance of the loading process. This fact is taken advantage of in a FEM-technique which allows the load to be applied in one single step, only, even when the incremental theory of plastic flow has to be used.Two self-similar problems are solved. Firstly an analytically solvable anti-plane strain crac
This article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingrai
Protein–protein interactions are fundamental to biological functions as well as the design of new functional food products and biomedicines. However, they can be challenging to computationally quantify due to strong forces and sensitivity to pronounced solution conditions. This thesis combines computational methods with Monte Carlo simulations to investigate strong protein interactions in diverse
How can an online course be designed to promote better mood and improved lighting and darkness conditions in the home? Based on the Information-Motivation-Behaviour Skills Model, the online course comprises multiple components (light, activity and sleep) and various learning strategies. Factual information is provided about, e.g. light as the most potent external time cue for the internal body clo
Rapporten sammanfattar fjärilsinventeringar utförda 2022 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet kunde totalt 35 ytor inventeras. Sammanlagt noterades 38 högnordiska blåvingar på 12 av 16 inventerade ytor, 34 dvärgpärlemorfjärilar på 14 av 17 ytor och 3 fjällsilversmygare noterades på 2 av 3 inventerade ytor. Svartfläckig blåvinge observerades på 23 av 56 inven
Achieving CRISPR Cas9-based manipulation of mitochondrial DNA (mtDNA) has been a long-standing goal and would be of great relevance for disease modeling and for clinical applications. In this project, we aimed to deliver Cas9 into the mitochondria of human cells and analyzed Cas9-induced mtDNA cleavage and measured the resulting mtDNA depletion with multiplexed qPCR. In initial experiments, we fou
In the 20th century, Sweden distinguished itself as one of the most organized and participatory democracies in the world. But in the late 19th century the situation was much the opposite – Sweden had for Western Europe a low degree of suffrage, and low political participation. To explain the turnaround, this paper explores the evolution of a democratic political culture in the final third of the 1
