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Spatiotemporal averaging resolution of high importance within Earth-observation-based light use efficiency models of gross primary production

Gross primary production (GPP) of the vegetation is the largest carbon exchange process of the global carbon cycle. Currently, within satellite-based remote sensing, GPP is generally modelled using linear light use efficiency models where GPP is related to photosynthetically active radiation absorbed by the green vegetation (APAR). These models work well on moderate to low spatiotemporal averaging

ECG-Based Detection of Acute Myocardial Infarction Using a Wrist-Worn Device

Background: A wrist-worn wearable device for acquiring limb and chest ECG leads (wECG) may constitute a promising approach to detection of acute myocardial infarction (AMI). However, it remains to be demonstrated whether the information conveyed by the wECG is sufficient for AMI detection. Objective: To explore explainable machine learning models for detecting AMI using the wECG. Methods: Two type

Sacred Spectacle: Spiritual Development, Religious Motifs, and Transcendental Style in Contemporary Musical Cinema

This study explores how contemporary musical cinema might employ audio-visual strategies and religious motifs in the depiction of character development, focusing on the examination of Les Misérables (2012), The Greatest Showman (2017), and The Color Purple (2023). By applying the ritual theories of Ronald Grimes, Christine Bell, and Victor Turner, the musicals are viewed from the perspective of ri

Termination of rotational bands : Disappearance of quantum many-body collectivity

One of the most interesting features of nuclei is the process by which specific configurations, manifest as collective rotational bands at intermediate spin values, gradually lose their collectivity and terminate in a non-collective state at the maximum spin which can be built within the configuration. Recent advances in both experiment and theory allow the study of this nuclear structure feature

Tradeoffs in expressed major histocompatibility complex diversity seen on a macro‐evolutionary scale among songbirds

To survive organisms must defend themselves against pathogens. Classical Major Histocompatibility Complex (MHC) genes play a key role in pathogen defense by encoding molecules involved in pathogen recognition. MHC gene diversity influences the variety of pathogens individuals can recognize and respond to and has consequently been a popular genetic marker for disease resistance in ecology and evolu

Patients With Intermittent Claudication and Chronic Widespread Pain Improves in Health-Related Quality of Life After Invasive but Not After Noninvasive Treatment

Background: Intermittent claudication (IC) is traditionally managed with risk factor modification, best medical treatment (BMT), and exercise training. Comorbidities such as diabetes and ischemic heart disease affect both results of invasive treatment and health-related quality of life (HRQoL) negatively. It is unknown how chronic widespread pain (CWP) influences the results of invasive treatment.

Lipid Bilayer-like Mixed Self-Assembled Monolayers with Strong Mobility and Clustering-Dependent Lectin Affinity

Glycans at the surface of cellular membranes modulate biological activity via multivalent association with extracellular messengers. The lack of tuneable simplified models mimicking this dynamic environment complicates basic studies of these phenomena. We here present a series of mixed reversible self-assembled monolayers (rSAMs) that addresses this deficiency. Mixed rSAMs were prepared in water b

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus

Glucokinase plays an important role in the regulation of insulin secretion and is therefore an attractive candidate gene for both insulin dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. A single G-A nucleotide polymorphism at the -30 position of the beta-cell specific promoter region of the glucokinase gene was previously associated with reduced beta-cell function. In the pre

Suppression of cholesterol 7 alpha-hydroxylase transcription and bile acid synthesis by an alpha(1)-antitrypsin peptide via interaction with alpha(1)-fetoprotein transcription factor

alpha(1)-Antitrypsin (alpha(1)-AT) is a serum protease inhibitor that is synthesized mainly in the liver, and its rate of synthesis markedly increases in response to inflammation. This increase in alpha(1)-AT synthesis results in an increase in peptides, like its carboxyl-terminal C-36 peptide (C-36), resulting from alpha(1)-AT cleavage by proteases. Atherosclerosis is a form of chronic inflammati

Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein-ligand struct

An international study of hospitalized cancer patients’ health status, nursing care quality, perceived individuality in care and trust in nurses : A path analysis

Background Providing high quality nursing care for patients with malignancies is complex and driven by many factors. Many of the associations between nursing care quality, trust, health status and individualized care remain obscure. Objective To empirically test a model of association linking hospitalized cancer patients’ health status, nursing care quality, perceived individuality in care and tru

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays

Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody frag

Atom and Group Transfer Reactions Involving High-valent Iron Complexes

Iron enzymes play critical roles in biological oxidation reactions by utilizing highly reactive high-valent iron intermediates, such as FeIV=O, FeV(O)(OH), and FeIV=NR species, for catalytic reactions. These intermediates exhibit remarkable catalytic behavior with high reactivities and high regio- and stereospecificity in various biochemical reactions. Understanding these metal intermediates is cr

Fundamental studies of gas sorption within mesopores situated amidst an inter-connected, irregular network

There has been little, or no, direct testing of theories of gas sorption within particular pores situated amidst a highly inter-connected pore network. The concept of thermodynamically independent pores within networks has also been challenged. In this work, a novel integrated nitrogen sorption and mercury porosimetry technique has been used to deconvolve the condensation and evaporation processes

Digital disruption diversified : FinTechs and the emergence of a coopetitive market ecosystem

This article analyses the development of FinTech companies in relation to traditional banks in four countries: Denmark, Estonia, the Netherlands and Sweden. Based on approaches drawn from the sociology of markets and field theory, we analyse and theorize about empirical data from secondary sources, official documents and 38 interviews with key actors. Whereas digital technologies have been commonl