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Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, stu

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort

Background: Recent genome-wide association studies (GWASs) have reported several genetic variants to be reproducibly associated with type 2 diabetes. Additional variants have also been detected from a metaanalysis of three GWASs, performed in populations of European ancestry. In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabet

Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard

Although rapid evolution of body size on islands has long been known, the ecological mechanisms behind this island phenomenon remain poorly understood. Diet is an important selective pressure for morphological divergence. Here we investigate if selection for novel diets has contributed to the multiple independent cases of island gigantism in the Skyros wall lizard (Podarcis gaigeae) and if diet, p

Providing better education services to the poor: Accountability and context in the case of Guatemalan decentralization

We explore how two community-based reform models align with the World Bank's World Development Report 2004 accountability framework. Using a qualitative case study of rural Guatemalan primary schools, we examine local governance through interviews with a range of stakeholders. While both reforms appear appropriate according to the World Bank's accountability framework, especially the model giving

Safety and efficacy of inhaled insulin (AERx((R)) iDMS(1)) compared with subcutaneous insulin therapy in patients with Type 1 diabetes: 1-year data from a randomized, parallel group trial

Assessment of the long-term safety and efficacy of liquid inhaled insulin via AERx((R)) insulin Diabetes Management System (iDMS) in a basal/bolus treatment regimen of adults with Type 1 diabetes. Patients were randomized 2 : 1 to prandial inhaled (n = 205) or subcutaneous (s.c.) (n = 99) insulin, plus one/two daily injections of neutral protamine Hagedorn (NPH) insulin for 12 months. The primary

A high pressure x-ray photoelectron spectroscopy study of CO oxidation over Rh(100).

We have studied the oxidation of CO over Rh(100) using high pressure x-ray photoelectron spectroscopy under CO and O2 pressures ranging from 0.01 to 1 mbar. The results show a very low or no conversion for the CO covered surface found at low temperatures, while the activity rises slightly when the temperature is high enough for some CO to desorb, exposing surface sites for dissociative O2 adsorpti

Wild Landscapes : The Cultural Nature of Swedish National Parks

Since their emergence in the late 19th century, national park spaces have been perceived as articulations of untouched nature or wild landscape beyond society. Yet no understanding of national parks can do without the recognition that they exist in historical spaces created, institutionalised and prepared for them by cultural practices and modes of representation. Rather than being given by nature

Tetra Evero Aseptic Sleeve Sealing Process - An Evaluation and Improvement Study

In May 2011 Tetra Pak launched the first carton bottle for aseptic milk, the Tetra Evero Aseptic (TEA). This Master Thesis aims to give proposals on how the future development of the mechanism working as a dolly when the inductor is making the longitudinal sealing (LS) on the package in the A6 filling machine, should be continued. The current LS mechanism is not fulfilling the requirements in func

Holocene relative sea-level changes in the Tasiusaq area, southern Greenland, with focus on the Ta4 basin

Populärvetenskaplig sammanfattning: Havsnivåförändringar på södra Grönland. Den globala havsnivån har förändrats under den nuvarande mellanistiden främst på grund av fördelningen av vatten mellan hav och glaciärer. Den relativa havsnivån på södra Grönland påverkas också till stor del av jordskorpans anpassning till storleken på det grönländska istäcket. I denna studie presenteras en ny strandförUntil recently there have only been a few observations of relative sea-level change from the inner Bredefjord area in southern Greenland. Here a new sea-level curve is presented from the Tasiusaq area based on data mainly from a sediment sequence from a marine embayment. Sea-level changes can be recorded in sediments as changed chemical composition, physical properties and macrofossil content. Iso

"De är människor, men jag är något annat": En intervjustudie om hur porrmissbruk kan se ut

The purpose of this paper was to examine how five persons who identify themselves as porn addicts view their addiction in terms of how the addiction have come about, what affective experiences they associate with the addiction, how it affects their relations to others, what makes them continue using pornography, what forms the addiction takes and how they live with their addiction today. Based on

Construction of an Instrument to Use Nanoparticles for Diffusion Capacity Measurements in Human Alveolar Regions for Diagnostics of Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD) was ranked as the sixth leading cause of death in 1990 and is projected to be the fourth leading cause of death worldwide by 2030 due to an increase in smoking rates and demographic changes in many countries (Mathers & Loncar 2006). To diagnose COPD there are several methods which are either imprecise or very expensive. The objective of this master

Counterfeiting and piracy from a rightholders perspective

This essay focuses on the increasing problems for companies and right-holders with counterfeited and pirated goods in the European Union and the problems for right holders to enforce their IPR rights. Will IPRED1 make a difference and is there really a need for the new Directive of Enforcement 2004/48/EG, or do the sanctions according to the TRIPS Agreement suffice. Further, IPRED2 is a follow up

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Occupational balance is a complex phenomenon with a number of different definitions. In this study, which purpose was to investigate how working occupational therapists describe and experience occupational balance, eight occupational therapists participated. The study had a qualitative approach including focus group interviews as a method. As the method of analysis qualitative content analysis wit

Linking Trade with Labour Rights: the ILO Garnment Sector Working Conditions Improvement Project in Cambodia

As of January 1, 2005, it will no longer be allowed under international trade rules for one country to impose import quotas on textiles and garments on another country. It is widely expected that the expiration of the 1974 Multifiber Arrangement will lead to a drastic re-shuffle of garment production and trade patterns. Where a number of countries were previously guaranteed a share of the European

Giving Voice to the Choices and Strategies of Poor People in Reaction to what they Imagine Housing Policies to be: A Micro-Ethnographic Study On ‘Juntando Manos’, a Housing Cooperative Located in the Reparto Mariana Sanzon, Leon-Nicaragua

The purpose of this micro-ethnographic study was to bring to light the choices and strategies of poor people in reaction to what they imagined housing policies to be in Nicaragua. The analysis used four of Bourdieu’s concepts which are Habitus, Capital, Field, and Agency and his structuralistic constructivism and interpretivism within a mainly phenomenological approach. Both approaches emphasized

Scaling Limits of Interacting Particle Systems: The case of SOS and WASEP

An interacting particle system is a stochastic process describing the evolution of finitely or infinitely many particles, each of which, in the absence of any interaction, would evolve like a Markov process. The particle system can be examined in different scales by grouping particles together and considering their average. Their behaviour is described by a Markov process on a microscopic scale, w

Sveriges ungdomar är vårt akuta problem - En studie om Sveriges hantering av unga lagöverträdare i förhållande till barnets bästa och offensiv kriminalpolitik

Den 21 november tillsatte den dåvarande regeringen en utredning för att se över regleringen av frihetsberövande påföljder som unga lagöverträdare kan dömas för. Augusti 2023 presenterade den svenska regeringen ett förslag om att införa ungdomsfängelser. Denna utredning uttryckte ett nödvändigt behov av förändrade och skärpta påföljder för unga lagöverträdare. Utredningen menar att behovet är starkIn November 2021, the Swedish government at the time appointed an investigation to review the regulation of custodial sanctions that young offenders may be sentenced to. In August 2023, the Swedish government published the investigation. This investigation expressed a necessary need for change and stricter sanctions for young people. The investigation argues that the need is strong against the bac

Climate clash: navigating the dilemma between carbon-intensive study abroad and climate action

Climate-focused study abroad relying on high-emitting travel poses a dilemma between study abroad and emission reductions. This study employs the three spheres of transformation investigating this dilemma through coding syllabi (n=156,) surveying educators (n=9,) and interviewing (n=14) Climate Action Network for International Educators (CANIE) affiliates considering whether studying climate chang