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Sales statistics indicate large variations in benzodiazepine consumption between the Scandinavian countries: the current difference between Denmark (highest) and Sweden (lowest) is almost two-fold. There are also large within-country variations: e.g. benzodiazepine sales in the Swedish city of Helsingborg, which is close to Denmark, were at the average Danish level and were the highest in Sweden.
Popular Abstract in Swedish Sjukdomen ärftlig hjärnblödning med cystatin C-amyloid angiopati (engelsk förkortning, HCCAA) beror på att en ärftlig mutation i genomet förändrar en byggsten (aminosyra) i proteinet cystatin C. Cystatin C-varianten som uppkommer deponeras som olösligt material (amyloid) i blodkärlens väggar och leder till att dessa ofta brister före 40-årsåldern med hjärnblödning som fHereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. The mutation causes an amino acid substitution Leu68 -> Gln in cystatin C (L68Q cystatin C) which results in deposition of the protein in the blood vessel
Popular Abstract in Swedish Avhandlingen utgörs av en detaljerad studie av ett enskilt antikt byggnadsverk – Caecilia Metellas mausoleum. Detta gravmonument tillhörde en högättad romersk kvinna och är beläget intill Via Appia strax utanför Rom. Byggnaden utmärker sig bland annat genom sin storlek, men också genom sin högst ovanliga arkitektoniska utformning. Syftet med studien är att söka förstå dThe present thesis constitutes a close study of a single architectural monument, the tomb of Caecilia Metella. This is a well-preserved cylindrical tomb situated on the Via Appia outside Rome, and it is generally associated with sepulchral buildings of the traditional tumulus type. An inscription reveals that the occupant of the grave was a noble woman belonging to one of the most prestigious fami
Understanding the molecular details of bioenergetic processes is fundamentally important. Defects in the mitochondrial energy metabolism can lead to untimely apoptosis and thus cause serious degenerative human diseases. Other defects in mitochondrial energy metabolism can have the reverse effect and cause cell immortality and also contribute to and high metastatic potential of tumor cells. Knowi
Objectives To study the impact of time in therapeutic range (TTR) and international normalised ratio (INR) variability on the risk of thromboembolic events, major bleeding complications and death after mechanical heart valve (MHV) implantation. Additionally, the importance of different target INR levels was elucidated. Methods A retrospective, non-randomised multicentre cohort study including all
Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no single set of criteria is universally accepted. Furthermore, there are gaps in the present criteria to identify individuals who have this condition. The reproducibility of the physiological findings, the relationship of symptoms to physiological findings, the presence of symptoms al
The five ribosomal P-proteins, denoted P0-(P1-P2)(2), constitute the stalk structure of the large subunit of eukaryotic ribosomes. In the yeast Saccharomyces cerevisiae, the group of P1 and P2 proteins is differentiated into subgroups that form two separate P1A-P2B and P1B-P2A heterodimers on the stalk. So far, structural studies on the P-proteins have not yielded any satisfactory information usin
A significant percentage of young children present cardiac murmurs. However, only one percent of them are caused by a congenital heart defect; others are physiological. Auscultation of the heart is still the primary diagnostic tool for judging the type of cardiac murmur. An automated system for an initial recording and analysis of the cardiac sounds could enable the primary care physicians to make
This study depicts how the Armenian massacres in the Ottoman Empire during World War I were perceived by a neutral small state, namely, Sweden. The Swedish knowledge should be of special interest since, as a neutral state during the entire conflict, Sweden had no immediate involvement or interest in the ongoing conflict; thus, any reporting about the events would have been untainted compared to th
Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 18 yr. Auer rods were the most consistent t(8;21)-associated morphological finding
Apolipoprotein B (apoB) containing lipoproteins, i.e. VLDL, LDL and Lp(a), are consequently lowered by ACTH treatment in humans. This is also seen as reduced plasma apoB by 20-30% and total cholesterol by 30-40%, mostly accounted for by a decrease in LDL-cholesterol. Studies in hepatic cell line (HepG2) cells showed that apoB mRNA expression is reduced in response to ACTH incubation and is followe
The present thesis investigates the usage of cultural heritage resources on the web. In recent years cultural heritage objects has been digitalized and made available on the web for the general public to use. The thesis addresses to what extent the digitalized material is used, and how findable it is on the web. On the web resources needs to be findable in order to be visited and used. The study i
Abstract in Norwegian Bakgrunn. Fallulykker er et viktig helseproblem hos eldre. Både balansetesting og registrering av egenrapportert funksjon kan være måter å forutse fremtidige ulykker på. Materiale og metode. I en kohortstudie ble egenrapportert gangfunksjon kartlagt hos 307 tilfeldig utvalgte hjemmeboende kvinner 75 år og eldre. Kvinnene gjennomgikk også testing av balanse og gangfunksjon, oBACKGROUND: Falls represent an important health problem among the elderly. Balance testing as well as registration of self-reported balance problems may be appropriate in order to predict the risk of future falls. MATERIALS AND METHODS: Self-reported walking was assessed in 307 randomly selected women 75 years or older living at home. The women underwent testing of gait and balance and were follow
Background: Foods with a low glycemic index are increasingly being acknowledged as beneficial in relation to the insulin resistance syndrome. Certain organic acids can lower the glycemic index of bread products. However, the possible effect of acids in fermented milk products on the glycemic index and on insulinemic characteristics has not been addressed. The metabolic effects of fermented milk or
We analyze a similar to 70 ks Chandra Advanced CCD Imaging Spectrometer exposure of the globular cluster omega Cen (NGC 5139). The similar to 17' x 17' field of view fully encompasses three core radii and almost twice the half-mass radius. We detect 180 sources to a limiting flux of similar to 4.3 x 10(-16) erg cm(-2) s(-1) (L-x = 1.2 x 10(30) erg s(-1) at 4.9 kpc). After accounting for the number
Background: The risk of venous tromboembolism (VTE) in women taking combined oral contraceptives (COCs) is attributed to changes in coagulation and fibrinolysis. The impact of the COCs may be greater in women with preexisting thrombophilic defects. Nevertheless most women who suffer from venous thrombosis do not have any of the well known hereditary or acquired risk factors. A simple and sensitive
