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Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis

Background: Several melanoma susceptibility genes have been identified. As part of the international genetic research programme of the GenoMEL consortiums research on genetic mutations in melanoma families, the aim of this study was to examine family members' views about their risk of melanoma, gene testing and genetic research. Methods: Self-report data were gathered using online and paper-based

There is little epidemiological data on heart failure (HF) in the younger age groups dominating clinical HF trials. We assessed gender-specific long-term HF incidence and mortality in an urban community-based sample of middle-aged subjects. Between 1974 and 1992, 33,342 HF-free subjects (10,900 [32.7%] women, mean age 45.7 +/- 7.4 years) were included in the Malmö Preventive Project, on average 21

BACKGROUND: Some autoimmune disorders have been linked to venous thromboembolism. We examined whether there is an association between autoimmune disorders and risk of pulmonary embolism. METHODS: We followed up all individuals in Sweden without previous hospital admission for venous thromboembolism and with a primary or secondary diagnosis of an autoimmune disorder between Jan 1, 1964, and Dec 31,

Product gas obtained through biomass gasification can be upgraded to hydrogen-rich synthesis gas. The synthesis gas can be further converted to liquid or gaseous fuels. However, the raw product gas contains both gas- and particle-phase impurities that can negatively affect both catalysts and hot-gas filters used for upgrading and cleaning. The present study aimed to characterize, both physically a

OBJECTIVES: To clarify whether the intensity of exposure to organic acid anhydrides (OAAs) is associated with the risk of sensitisation to these allergens. METHODS: The investigations were carried out in three different manufacturing plants (A, B, and C) where OAAs were used in the production of epoxy resins. Methyltetrahydrophthalic acid anhydride (MTHPA) was used in all three plants. The exposur

Purpose: To examine whether panretinal photocoagulation for severe non-proliferative retinopathy in type 1 diabetes patients could halt the progression of retinopathy with subsequent vitreous haemorrhages and visual impairment. Methods: During a 10-year follow-up study period of 344 type 1 diabetes patients, 81 subjects went through panretinal photocoagulation. Forty patients were treated for sev

Objectives To describe the endosonographic image of the anal sphincter 2-7 days after delivery in women who had undergone a primary repair of an obstetric sphincter tear. Methods Forty-eight women who had suffered a third- or fourth-degree sphincter tear at delivery and had undergone primary sphincter repair were examined with endoanal sonography 2-7 days after delivery. A score from 0 to 16 was

Popular Abstract in Swedish Denna avhandling behandlar tre centrala områden i finansiell ekonomi i allmänhet och portföljvalsteori i synnerhet: riskmåttet, estimeringsrisk och tidsdiversifiering. Avhandlingen består av fem kapitel varav ett är ett kort introduktionskapitel. De första två kapitlen behandlar ett alternativt mått på risk, lower partial moment (LPM). Detta alternativa mått behandlar eThis thesis is devoted to the analysis of three important issues in financial economics in general and portfolio selection in particular: the risk measure, estimation risk and time diversification. Besides a short introductory chapter the thesis consists of four empirical essays. In the second chapter, the effect of estimation risk on the efficient frontier in the lower partial moment framework is

Leptin is a key biological marker related to energy balance and development of diabetes and cardiovascular diseases. Its levels are increased in populations with a high degree of the metabolic syndrome. Life history of evolution has, however, largely taken place under the ecological context of hunting and gathering. In this study, we explored whether the first steps of transition to sedentary agri

Background Calcipotriol and betamethasone dipropionate are both widely used, effective treatments for psoriasis. Vitamin D analogues and topical corticosteroids have different mechanisms of action in the treatment of psoriasis. A new vehicle has been developed in order to contain both calcipotriol (50 micro g g-1) and betamethasone dipropionate (0.5 mg g-1) in an ointment form. By using calcipotri

Purpose: The purpose of this work was to evaluate the visibility of simulated lesions in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Methods: Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens Healthcare, Erlangen, Germany) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the

Popular Abstract in Swedish All materia består av atomer. Avhandlingen du just nu läser är uppbyggd av atomer; till och med du själv är uppbyggd av atomer. En kemist är intresserad av vilka atomer som hänger ihop för att bilda molekyler och hur dessa molekyler kan sammanfogas till fasta material. Man kan likna det vid att molekylerna är en byggsten som då de sammanfogas bildar en byggnadskonstruktHow do molecules arrange themselves in a crystal? It is today not possible to definite predict the three-dimensional packing arrangement of molecules in the crystalline solid state. The aim of the work presented in this thesis has been to gain more knowledge of what principles that govern molecular packing. Platinum(II) complexes have been chosen as model system since these compounds are stable,

Popular Abstract in Swedish Det har nu gått 20 år sedan ett utbrott av ledinflammation (arthrit), i Connecticut, USA, satte forskarna på spåret till den sjukdomsbild som vi idag kallar fästingöverförd borreliainfektion och det är snart 15 år sedan man lyckades isolera bakterien som orsakar sjukdomen, Borrelia burgdorferi. Symptomen på sjukdomen har visserligen varit kända sedan sekelskiftet men he

BACKGROUND: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk.METHODS: We measured midregional proatrial natriuret

BACKGROUND: The incidence of distal radius fracture has increased substantially during the last 50 years according to several studies that estimated the overall incidence in various general populations. The incidence of fracture classified according to severity has not been well documented. The aim of this population-based study was to estimate the overall and type-specific incidence rates of dist

Background: The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood. Research Design and Methods:Given that the genetic background contributes to both traits, it is conceivable that genetic variants associated with T2D may also

The load transfer and redistribution phenomenon that occurs through the mobilization of shear stresses in response to relative displacements in granular materials, such as soils, is attributed to the arching effect. The arching effect has a great influence on the behaviour of soils and plays an important role in predicting earth pressure in granular backfills of limited extent, confined by unyield