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Anthracyclines and taxanes are active cytotoxic drugs in the treatment of early metastatic breast cancer. It is yet unclear whether addition of capecitabine to the combination of these drugs improves the treatment outcome. Patients with advanced breast cancer were randomized to first-line chemotherapy with a combination of epirubicin (Farmorubicin(A (R))) and paclitaxel (Taxol(A (R))) alone (ET) o

Trötta ögon, huvudvärk, för kallt eller för varmt och allmänt lägre prestationsförmåga. Så kan det se ut på ett kontor med dålig ventilation och detta minskar förtjänsten för företaget samtidigt som det för de anställda upplevs påfrestande. Med ett väl dimensionerat, och rätt valt tilluftssystem blir inomhusklimatet avsevärt bättre och de anställda har de bästa förutsättningarna att med glädje preThis study compares the two traditional ventilation methods ; mixed ventilation and displacement ventilation, with a new type of dif fuser which attempts to solve the problem with blockage of the diffuser for the displacement ventilation. This new diffuser called Airshower is a product developed by Airson engineering AB whom is also the company where all simulations and tests for this study were

This study has investigated the possibilities of coating additive manufactured titanium dental prosthesis structures. Different coating alternatives were evaluated with the regards of esthetics, function and implementation possibilities. The coatings were applied on test samples and the adhesion between the printed titanium structures and the coating as well as to resin veneering applied on top wa

Internationellt samarbete är centralt för att ta itu med de globala utmaningar som världen står inför, en av dessa är spridningen av antimikrobiell resistens. Åtgärder, som begränsar den internationella handeln, används ofta av länder för att uppnå politiska mål. I Världshandelsorganisationen (WTO) har relation mellan handel och icke-ekonomiska politiska mål, som miljö- och hälsohänsyn, diskuterat

Att kunna göra tillförlitliga prognoser är varje läkares mål. Med hjälp av maskininlärning, framförallt neurala nätverk, har vi tagit fram modeller som presterar bättre än tidigare studier. Årligen drabbas hundratusentals människor världen över av ett hjärtstopp utanför sjukhuset (eng. OCHA). Tyvärr är chansen att man överlever endast mellan 5 till 10 procent. Om man överlever det initiala hjärtstArtificial Neural Networks (ANN) are used to prognosticate the outcome of patients suffering from an out-of-hospital cardiac arrest. A prognosis is made for different periods, dependent on when data becomes available: at admission, day one, day two, and day three. Previous research has achieved an Area Under the Curve (AUC) of around 0.82 for the early prediction (admission) using the same data. T

I den rättskipande verksamheten har förhör en central plats. Under förundersökningen bidrar förhör med att driva utredningen framåt och under huvudförhandlingen fungerar dessa som bevisning. I och med den centrala rollen förhör spelar bör det ses som viktigt att dessa bedrivs på ett tillfredsställande sätt. Uppsatsen har ett tvärvetenskapligt perspektiv och undersöker utifrån rättspsykologisk och Interrogation has a central place in the administration of justice. During the preliminary investigation the interrogation is used to move the case forward and during the main hearing the questioning acts as evidence. Due to the central part that the interrogation and questioning takes it should be considered important that it is conducted in a satisfactory way. This thesis has an interdisciplinar

This presentation reports on a study of the writing behaviour of some (n=21) Swedish speaking 14-15-year olds when composing in Swedish, their first language, and in English as a foreign language. The approach taken in this study is a psycholinguistic/cognitive one using the key-stroke logging tool, ScriptLog (Strömqvist & Karlsson, 2002; Strömqvist & Malmsten, 1998, see www.scriptlog.net

The purpose of this study was to investigate the understanding of the diagnoses ADHD and DAMP within different professional categories in the educational system, how it is being addressed and how this affect their work with children diagnosed with ADHD or DAMP. We also wanted to shed some light on the debate between Kärfve and Gillberg, about whether the diagnoses of ADHD and DAMP are social const

In this thesis a comparative study of Sweden and Thailand was conducted in order to find out why Sweden is top-ranked and Thailand low-ranked on an e-learning readiness scale. More specifically, I was focusing on the net universities in Sweden and in Thailand. The net universities and the countries were contrasted in order to find out, not only if the differences or similarities had any influence

Background: Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavioural variant FTD (bvFTD). This is known to be a varied disorder with a mixture of tau-positive and tau-negative underlying pathologies. The other subtypes include semantic dementi

Objective To investigate the possible association of the BANK1 gene with genetic susceptibility to systemic sclerosis (SSc) and its subphenotypes. Methods A large multicentre case-control association study including 2380 patients with SSc and 3270 healthy controls from six independent case-control sets of Caucasian ancestry ( American, Spanish, Dutch, German, Swedish and Italian) was conducted. Th

Background: Currently available biomarkers for the early tissue process leading to joint damage in rheumatoid arthritis are insufficient and lack prognostic accuracy, possibly a result of variable activity of the disease over time. This study represents a novel approach to detect an altered activity of the disease process detected as increasing serum-COMP levels over a short time and whether this

Objective. Helicobacter pylori infection is an established risk factor for non-cardia gastric adenocarcinoma. Infection with H. pylori strains harbouring the cagA pathology island may augment this association. H. pylori infection may at the same time reduce the risk for oesophageal carcinoma. However, prospective data on the association between CagA seropositivity and gastric or oesophageal carcin

BACKGROUND: Reduced lung function has been associated with increased rates of myocardial infarction. Whether the occurrence and prognostic significance of ventricular arrhythmia is related to lung function is largely unknown. METHODS AND RESULTS: We performed a population-based study of 68-year-old men without a history of stroke or myocardial infarction; 402 men participated. Mortality and corona

High poly(3-hydroxybutyrate) (PHB) content and volumetric productivity were achieved by fed-batch culture of Halomonas boliviensis using a defined medium. Initial shake flask cultivations in a minimal medium revealed that the growth of H. boliviensis was supported only when the medium was supplemented with aspartic acid, glycine, or glutamine. Addition of 0.1% (w/v) glutamine in the medium resulte

Objective To compare drug survival on adalimumab, etanercept and infliximab in patients with rheumatoid arthritis (RA). Methods Patients with RA (n=9139; 76% women; mean age 56 years) starting their first tumour necrosis factor (TNF) inhibitor between 2003 and 2011 were identified in the Swedish Biologics Register (ARTIS). Data were collected through 31 December 2011. Drug survival over up to 5 ye

ABSTRACT: BACKGROUND: The two-step dilute acid hydrolysis (DAH) of softwood is costly in energy demands and capital costs. However, it has the advantage that hydrolysis and subsequent removal of hemicellulose-derived sugars can be carried out under conditions of low severity, resulting in a reduction in the level of sugar degradation products during the more severe subsequent steps of cellulose hy