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Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy. Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis. Material and methods: We used populat

In August 2008, Georgia was engaged in an internal armed-conflict with its breakaway region of South Ossetia, which shortly after, grew into a large-scale war with Russian Federation. In the course of the war, hundreds of civilians became victims of the international crimes committed by belligerent sides. Hence, the central issue of my research is a post-conflict justice. In particular, if there e

Popular Abstract in Swedish Vid en knäprotesoperation ersätts ledytorna i knäet med en protes gjord av metall och plast. Den vanligaste orsaken till denna operation är artros(ledsvikt. Antalet knäprotesoperationer ökar stadigt och 2009 utfördes 12,700 förstagångsoperationer i Sverige. Resultaten är överlag goda men en allvarlig komplikation som drabbar mellan 1 och 2% av patienterna är bakterieinfThe Swedish Knee Arthroplasty Register (SKAR) was used to identify 478 cases that underwent a first-time revision with exchange or removal of the prosthesis due to infection during the years 1986–2000. 30% of the infections were diagnosed within 3 months from primary operation and two-thirds were diagnosed within 2 years. These cases frequently had a history of wound complication after the primar

We have estimated the hydration free energy for 20 neutral drug-like molecules, as well as for three series of 6-11 inhibitors to avidin, factor Xa, and galectin-3 with four different continuum solvent approaches (the polarised continuum method the Langevin dipole method, the finite-difference solution of the Poisson equation, and the generalised Born method), and several variants of each, giving

Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379

AIM: We aim to compare machine learning with neural network performance in predicting R0 resection (R0), length of stay > 14 days (LOS), major complication rates at 30 days postoperatively (COMP) and survival greater than 1 year (SURV) for patients having pelvic exenteration for locally advanced and recurrent rectal cancer.METHOD: A deep learning computer was built and the programming environment

As pharmaceutical removal was not part of the of the modern wastewater treatment plant (WWTP) design, it is not surprising that WWTPs have been identified as major point sources of pharmaceuticals entering the environment. The oxidation of pharmaceuticals in the WWTP effluent is one of the-end-of-pipe solutions that are considered most ready for full-scale use. However, there are several aspects oAs pharmaceutical removal was not part of the of the modern wastewater treatment plant (WWTP) design, it is not surprising that WWTPs have been identified as major point sources of pharmaceuticals entering the environment. The oxidation of pharmaceuticals in the WWTP effluent is one of the-end-of-pipe solutions that are considered most ready for full-scale use. However, there are several aspects o

Background: Open repair (OR) for popliteal artery aneurysm (PAA) has recently been challenged by endovascular repair (ER) as the primary choice of treatment. The aim of the present study was to evaluate time trends in treatment modality and compare outcomes between OR and ER among electively operated patients after start of screening in 2010 for abdominal aortic aneurysm (AAA), a disease highly as

BACKGROUND: The Pediatric Heart Network designed a clinical trial to compare aortic root growth and other short-term cardiovascular outcomes in children and young adults with Marfan syndrome randomized to receive atenolol or losartan. We report here the characteristics of the screened population and enrolled subjects.METHODS AND RESULTS: Between 2007 and 2011, 21 clinical sites randomized 608 subj

The combination of a negative D-dimer and a Wells score can rule out, but not confirm, a diagnosis of deep venous thrombosis (DVT). We aimed to identify new diagnostic biomarkers for DVT and to investigate their relationship with hypercoagulability markers [D-dimer and activated protein C-protein C inhibitor (APC-PCI) complex]. We screened 92 cardiovascular-specific proteins in plasma samples from

Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and

Shedding of epithelium, increased venular permeability, and traffic of activated eosinophils and neutrophils may characterize asthmatic airways. This in vivo study involving briefly anesthetized guinea pigs examines whether epithelial denudation itself affects airway venules and granulocytes. Using an oral probe, a de-epithelialized tracheal zone (0.8 x 30 mm) was produced without bleeding or dama

Effects of a mindfulness-based program, Compassion and Attention in the Schools (Compas), were studied in 358 pupils in grades 5, 7, and 8 in Sweden. An experimental group undertook Compas practices in class three times a week during an eight-week period. A control group undertook content area academic lessons . Pre-/post-intervention analyses showed a significant improvement in the experimental gEffects of a mindfulness-based program, Compassion and Attention in the Schools (Compas), were studied in 358 pupils in grades 5, 7, and 8 in Sweden. An experimental group undertook Compas practices in class three times a week during an eight-week period. A control group undertook content area academic lessons . Pre-/post-intervention analyses showed a significant improvement in the experimental g

The effect of pH on the kinetics of the bioelectrocatalytic reduction of H2O2 catalysed by horseradish peroxidase (HRP) has been studied at –50 mV vs. AgjAgCl on HRP-modified Au electrodes placed in a wall-jet flow-through electrochemical cell. Native HRP (nHRP) and a nonglycosylated recombinant form containing a six-histidine tag at the C-terminus, CHisrHRP, produced by genetic engineering of non

RATIONALE AND OBJECTIVES: This study was performed to document the perceived decrease in fatty involution at screening mammography during the past decade and evaluate the influence of hormone replacement therapy (HRT). MATERIALS AND METHODS: In December 1996, the mammograms of 261 consecutive screening patients with a comparison study obtained 5 years earlier were evaluated, and their breasts were

Aim: With fast track surgery and shorter hospital stay, discharge from hospital after cancer surgery is becoming more challenging for the individual patient. The aim of this study was to explore how patients perceive information after surgery for colorectal cancer, what their information needs are and to determine factors affecting received information. Method: One hundred patients filled in the q

Aim: The aim of this study was to evaluate if a general school-based exercise intervention programme in pre-pubertal boys would render site-specific benefits in bone mineral accrual and gain in femoral neck structure. Methods: Eighty boys aged 7-9 years were included in a curriculum-based exercise intervention programme comprising 40 min of general physical activity per school day (200 min/week) f

BACKGROUND: Cytomegalovirus (CMV) specific T-cells are known to provide long-term control of CMV reactivation, which is a frequent complication of hematopoietic stem cell transplantation. We have studied 58 pediatric patients after hematopoietic stem cell transplantation who suffered from CMV reactivation to reveal which functional T cell subset is best correlating with successful reactivation res