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Rational drug design is predicated on knowledge of the three-dimensional structure of the protein-ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy is rarely addressed in drug design. In this work, we have probed the conformational entropy and its relative contributi

Fibroblast-mediated collagen gel contraction depends on collagen-binding ss1 integrins. Perturbation of these integrins reveals an alternative contraction process that is integrin aVss3-dependent and platelet-derived growth factor (PDGF) BB-stimulated. Connective tissue cells actively control interstitial fluid pressure (IFP) and inflammation-induced lowering of IFP provides a driving force for ed

Central Pattern Generators (CPGs) produce rhythmic behaviour across all animal phyla. Cnidarians, which have a radially symmetric nervous system and pacemaker centres in multiples of four, provide an interesting comparison to bilaterian animals for studying the coordination between CPGs. The box jellyfish Tripedalia cystophora is remarkable among cnidarians due to its most elaborate visual system.

Value added tax (VAT) is a key part of the fiscal revenue of many countries. Yet this broad-based tax on consumer spending exempts financial services. This seems puzzling to many, particularly given the significance of that sector and the size of its value-added in today's world economy. The fact that the European Commission is currently reviewing the tax treatment of financial activities in the E

Many houses of the “miljonprogrammet” is now facing a major improvement need, and not least in terms of energy improvement, Drottninghög in Helsingborg is one such area. It is a houses from Drottninghög that is used as an example in this report. The energy improvements addressed in this report is mainly concerning construction improvements. The building from Drottninghög is poorly insulated whit t

Cross-border commerce involves problems not only in respect of Private Law but also within the field of Marketing Law. During the end of the year 2002 and during the year 2003, several messages by foreign betting companies could be seen in the Swedish press. Some had the message that the gambling monopoly should be stopped&semic others were more of the ''traditional'' marketing

Ökar aktieägaravkastningen för aktieägarna efter nyheten om förvärv? Syftet med uppsatsen är att undersöka om aktieägare i det förvärvande bolaget (för bolag listade på Large Cap vid Nasdaq OMX Stockholm) gynnas vid offentliggörandet av ett förvärv. Vidare är syftet att undersöka ett antal faktorer som eventuellt kan påverka aktieägaravkastningen. Uppsatsen baseras på en eventstudie och använder s

The ability of protein kinase C and casein kinase 2 substrate in neurons (PACSIN)/syndapin proteins to self-polymerize is crucial for the simultaneous interactions with more than one Src homology 3 domain-binding partner or with lipid membranes. The assembly of this network has profound effects on the neural Wiskott-Aldrich syndrome protein-mediated attachment of the actin polymerization machinery

The focus of this work is detecting pedestrians, captured in a surveillance setting, and locating them in world coordinates. Commonly adopted search strategies operate in the image plane to address the object detection problem with machine learning, for example using scale-space pyramid with the sliding windows methodology or object proposals. In contrast, here a new search space is presented, whi

Twin studies on cancer have addressed two general questions, one about the possible carcinogenic effects of twinning and the second about heritable effects of cancer. The first question is answered by comparing the occurrence of cancer in twins to that in singletons; the second is answered in probandwise analysis of monozygotic twins compared to dizygotic twins or siblings. We used the nationwide

A new Grain stream cipher, denoted Grain-128AEAD is presented, with support for authenticated encryption with associated data. The cipher takes a 128-bit key and a 96-bit IV and produces a pseudo random sequence that is used for encryption and authentication of messages. The design is based on Grain-128a but introduces a few changes in order to increase the security and protect against recent cryp

Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an

In the present study, we investigate degradable anionic dendritic nanogels (DNG) as carriers for antimicrobial peptides (AMPs). In such systems, the dendritic part contains carboxylic acid-based anionic binding sites for cationic AMPs, whereas linear poly(ethylene glycol) (PEG) chains form a shell for promotion of biological stealth. In order to clarify factors influencing membrane interactions of

Recent advancements in catchment hydrology (such as understanding hydrological processes, accessing new data sources, and refining methods for parameter constraints) make it possible to apply catchment models for ungauged basins over large domains. Here we present a cutting-edge case study applying catchment-modelling techniques at the global scale for the first time. The modelling procedure was c

Introduction: Emergency departments (ED) globally are addressing the coronavirus disease 2019 (COVID-19) pandemic with varying degrees of success. We leveraged the 17-country, Emergency Medicine Education & Research by Global Experts (EMERGE) network and non-EMERGE ED contacts to understand ED emergency preparedness and practices globally when combating the COVID-19 pandemic. Methods: We elect

The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2) and serum response factor (SRF). Using a bioinformatics approach, we found that CSPG4, MCAM, and AOC3 correlate with MYOCD, MRTF-A/MKL1, and SRF across human tissues. No other transcription factor correlat

Purpose: Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Using real-world data, we evaluated the risk of digitalis intoxication in concomitant users of dronedarone and digoxin compared digoxin-alone users. Methods: We used the Clinformatics DataMart, a US claims database, to identify adult patients with atrial fibrillation (AF) or atrial flutter (AFL) who conco

Intensification of arable crop production degrades soil health and production potential through loss of soil organic carbon. This, potentially, reduces agriculture's resilience to climate change and thus food security. Furthermore, the expected increase in frequency of adverse and extreme weather events due to climate change are likely to affect crop yields differently, depending on when in the gr

Pilot-scale tests were run with ozonation for reduction of 24 pharmaceuticals at 10 full-scale wastewater treatment plants in southern Sweden. Reduction was evaluated based on doses of 3, 5 and 7 g O3/m3 at all plants. The reduction of pharmaceuticals reached on average 65% at 3 g O3/m3, 78% at 5 g O3/m3 and 88% for 7 g O3/m3 in terms of total concentration of pharmaceuticals. Specific ozone dose Pilot-scale tests were run with ozonation for reduction of 24 pharmaceuticals at 10 full-scale wastewater treatment plants in southern Sweden. Reduction was evaluated based on doses of 3, 5 and 7 g O3/m3 at all plants. The reduction of pharmaceuticals reached on average 65% at 3 g O3/m3, 78% at 5 g O3/m3 and 88% for 7 g O3/m3 in terms of total concentration of pharmaceuticals. Specific ozone dose