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Protein structure-function relationships can be studied by using linker insertion mutagenesis, which efficiently identifies essential regions in target proteins. Bacteriophage Mu in vitro DNA transposition was used to generate an extensive library of pentapeptide insertion mutants within the alpha-complementing domain 1 of Escherichia coli beta-galactosidase, yielding mutants at 100% efficiency. E

Abstract Objectives. To establish a set of reference values for regional dispersion of repolarization of the right atrium in the in situ heart of pigs and to see if the global dispersion of repolarization could be estimated from regional mapping. Design. Monophasic action potential (MAP) were sequentially recorded from 28 ± 3 sites in seven different regional areas of the right atrium: lateral, a

OBJECTIVES: To illuminate patterns observed in International Cancer Benchmarking Programme studies by extending understanding of the various influences on presentation and referral with cancer symptoms.DESIGN: Cross-country comparison of Denmark, England and Sweden with qualitative analysis of in-depth interview accounts of the prediagnostic process in lung or bowel cancer.PARTICIPANTS: 155 women

With the theme of the research conference of the NNHSH network we want researchers, both at doctoral and post-doctoral level, to reflect on how health practices and health policies in the Nordic Welfare States are being transformed and have been transformed in the past. The Nordic countries are all, more or less, in the midst of a transformation from a social democratic health care system, based o

For almost forty years the seemingly harmless term “postmodern” has sown discord and ruffled feathers in the intellectual world. Mere sight of the term has caused some commentators to see red in more than one sense: “postmodernism” for them embodies the utter degeneracy of the 1960s Left. For their part, more than a few commentators on the left have associated the term with the neoliberal climate

Human cystatin C (hCC) is a cysteine proteinase inhibitor involved in pathophysiological processes of dimerization and amyloid formation. These processes are directly associated with a number of neurodegenerative disorders such as Alzheimer disease or hereditary cystatin C amyloid angiopathy (HCCAA). One of the ideas on how to prevent amyloid formation is to use immunotherapy. HCC3 is one of a gro

The behaviour of Grapholita molesta (Busck) (Lepidoptera: Tortricidae) males was studied in overlapping sex pheromone plumes in a wind tunnel. The ultimate aim of the study was to assess the effect of different treatments on male behaviour and consider the observed changes within the context of the suggested mechanisms underlying mating disruption. Two baits were placed either in series or paralle

Glyoxalase I (GlxI) is a member of the glyoxalasesystem, which is important in cell detoxification and convertshemithioacetals of methylglyoxal (a cytotoxic byproduct of sugarmetabolism that may react with DNA or proteins and introducenucleic acid strand breaks, elevated mutation frequencies, andstructural or functional changes of the proteins) and glutathioneinto D-lactate. GlxI accepts both the

α1-Adrenergic receptors from the cultured smooth muscle cell line (DDT1 MF-2) have been solubilized with digitonin and purified to apparent homogeneity by sequential chromatography on a biospecific affinity support (Sepharose-A55453 (4-amino-6,7-dimethoxy-2-[4-[5-(4-amino-3-phenyl)pentanoyl]- 1-piperazinyl]-quinazoline), an α1 receptor-selective antagonist), a wheat germ agglutinin-agarose gel, an

Aeolian deposits in Sweden and Norway are poorly explored as environmental records. Many, mainly small, occurrences of windblown sand have been mapped, but few have been investigated in any detail and even fewer have been absolutely dated. Here we present results from a project aiming to determine the timing and magnitude of wind activity in inland settings in southern Sweden and Norway and to bet

The contribution of forest harvesting to base cation losses and soil acidification has increased in recent years in Sweden, as the demand for bioenergy has increased and the sulphur deposition has decreased. Thus, new policy tools are required to evaluate the progress of the recovery from acidification, and as a basis for forest management recommendations. In this study we introduce and test a con

Background: Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of the P-wave duration for development of AF. QRS vector magnitude has had a predictive value in ventricular arrhythmia development. We aimed to asses

Chondrocytes obtained from epiphyseal cartilage of fetal guinea pigs or ear cartilage of young rabbits were cultured in monolayer. The influence of colchicine, cytochalasin B, and p-nitrophenyl-β-d-xylopyranoside on secretion of proteoglycans was investigated. Radioactive sulfate was used as a precursor. As observed previously in other systems, β-d-xylosides initiated the synthesis of free chondro

Even though language proficiency in children is strongly related to success in almost all domains, neurocognitive studies of L2 processing are typically limited to adults with several years of exposure, who may use general cognitive mechanisms to compensate for any difficulties in L2 processing. For example, whereas previous studies of adult bilinguals have reported differences in the anterior neg

In June 2001 the Shanghai Cooperation Organization or SCO was formally inaugurated. The SCO had as of 2001 as its full members China, Russia, Kakakhstan, Kyrgyzstan, Uzbekistan and Tajikistan. Since that time Mongolia, India, Pakistan and Iran have been accepted as observers. There is speculation that Turkmenistan, following its recent change of regime, may also join the SCO in some way in the nea

Hogia is a development company in the software industry. One of the products they deliver is a web-based portal for the accounting and auditing industry. This portal is a platform for agencies linking communication with their customers. The portal today lacks the ability of notifying customers, for instance via email, when a new event that concerns the customer has been added. This could for examp

The purpose of this Master’s Thesis was to examine different usage applications for animations and to develop one or several animated products for Sony Ericsson Mobile Communications AB. The overall objective was to develop an animated tool for information purposes and to investigate different interesting fields of application for the animated products. The goal was also to show the procedure of c

OBJECTIVES: To study the effects on the number of laboratory tests ordered after introduction of cost display (showing the cost in the computerized test ordering system at test ordering and test result delivery) and cost charge (requiring all primary healthcare centers to pay full laboratory costs of the ordered tests). STUDY DESIGN: The study included cost display for secondary healthcare centers

Utvecklingsplan för forskarutbildning i hållbarhetsvetenskap vid LUCSUS Sida 1 av 5 Fakultetsstyrelsen UTVECKLINGSPLAN Diarienummer STYR 2022/2762 2024-02-01 Utvecklingsplan för forskarutbildning i hållbarhetsvetenskap vid LUCSUS Bakgrund Under våren 2023 utvärderades forskarutbildningen i hållbarhetsvetenskap. I expertgruppen ingick Anders Hansson, docent vid Linköpings universitet (ordförande) o

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2024-04/beslut-utvecklingsplan-lucsus.pdf - 2026-05-27