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The effects of central cholinergic blockade on spatial memory were tested in aged and basal forebrain-lesioned rats using the Morris Water Maze. In Experiment 1, aged rats (18-21 months old) were characterized as behaviorally impaired or nonimpaired based on water maze performance prior to an atropine sulfate challenge. In the atropine test (50 mg/kg, IP), both the impaired and the nonimpaired rat

Active sites in Mo-based hydrotreating catalysts are produced by sulfidation. To achieve insights that may enable optimization of the catalysts, this process should be studied in situ. Herein we present a comparative XAFS study where the in situ sulfidation of Mo/δ-Al2O3 and Ni/δ-Al2O3 is compared to that of δ-Al2O3 supported NiMo catalysts with different NiMo ratios. The study also covers the com

ABSTRACTObjectivesAn emerging body of research reveals a heightened risk of gambling problems among elite athletes, particularly among males, but these studies often suffer from small sample sizes and lack diverse representation across sports and groups. This study aimed to investigate gambling problems and their correlates among elite male and female ice hockey players in Sweden’s top leagues.Met

divided the data set temporally, assessing the persistence of identified subgroups over different periods. The reassessment of mortality risk used the targeted maximum likelihood estimation (TMLE) method to achieve more robust causal modeling. Results: We analyzed data from 21,005 children. The mortality risk (6 weeks to 3 years of age) was 5.2% (95% CI 4.8%-5.6%) for children born between 2003 an

We have calculated redox potentials of the two metal clusters in Mo-nitrogenase with quantum mechanical (QM) calculations. We employ an approach calibrated for iron–sulfur clusters with 1–4 Fe ions, involving QM-cluster calculations in continuum solvent and large QM systems (400–500 atoms), based on structures from combined QM and molecular mechanics (QM/MM) geometry optimisations. Calculations on

ABSTRACT: Secretory leucocyte protease inhibitor, SLPI, is a low‐molecular‐weight, acid‐stable protein present in the liquid part of fresh human ejaculate but not demonstrable in the gel structure. No fragmentation of SLPI occurred during gel dissolution, but a slow proteolytic cleavage of SLPI was seen on incubation of the liquified semen at 37°C. The same pattern of degradation products was seen

This article draws on usability evaluations of a behavioural change intervention delivered as a web-based course. Special attention was given to usability as the course is directed at older adults aged 70 and above. Experiences from the usability evaluations in a lab environment and the real world, followed by stepwise refinements, can serve as examples of what must be considered in developing cou

Sea turtles are known to perform long-distance, oceanic migrations between disparate feeding areas and breeding sites, some of them located on isolated oceanic islands. These migrations demonstrate impressive navigational abilities, but the sensory mechanisms used are still largely unknown. Green turtles breeding at Ascension Island perform long oceanic migrations (>2200 km) between foraging areas

Understanding the development of spatial patterns in generalist predators will improve our ability to incorporate them into biological control programs. We studied the small-scale spatial patterns of spider webs in alfalfa by analyzing the relationship between web locations over distances ranging from 4 to 66 cm. Using a coordinate-based spatial statistic (O-ring) and assuming a heterogeneous dist

The aim of this study is to develop better understanding on organized self-help housing as an enabling shelter and development strategy to overcome poverty and build more resilient communities. The study addresses organized self-help housing from three different perspectives: a) current practice in developing countries; b) institutional approaches; and, c) the organized self-help housing process.

Glacifluvial deposits along an ice-marginal zone,in Smaland, southern Sweden, have been dated using post-IR blue OSL. To test for incomplete bleaching, we adopted two strategies: analysis of modern analogues and small-aliquot dose distributions. Samples of modern fluvial sediments show no significant incomplete bleaching; they yield equivalent doses of only 0.5-2 Gy (similar to 0.25-4% of our glac

Glioblastoma multiforme (GBM) is the most common brain tumor in adults. It presents an extremely challenging clinical problem, and treatment very frequently fails due to the infiltrative growth, facilitated by extensive angiogenesis and neovascularization. Pericytes constitute an important part of the GBM microvasculature. The contribution of endogenous brain pericytes to the tumor vasculature in

Background: It has been found that patch testing with 15μl formaldehyde 2.0% aq detects twice more allergies than testing with 1.0%. The clinical relevance of positive patch test reactions is often difficult to determine. Use tests are simple to do and help to evaluate the significance of patch test results. Objectives: To study the clinical relevance of contact allergy to formaldehyde detected by

Due to uncertainties regarding clinically meaningful gains from adjuvant chemotherapy after colorectal cancer surgery, several Nordic Groups in the early 1990s initiated randomised trials to prove or reject such gains. This report gives the joint analyses after a minimum 5-year follow-up. Between October 1991 and December 1997, 2 224 patients under 76 years of age with colorectal cancer stages II

Abstract in UndeterminedMany species of birds show evidence of secondary contact zones and subspeciation in their Scandinavian distribution range, presumably resulting from different post-glacial recolonization routes. We investigated whether this is the case also in the Scandinavian bluethroat Luscinia svecica, a species that has been suggested to consist of two separate populations: one SW-migra

Many people have experienced computers not doing what they were expected to do or, perhaps more often, met with computers that deliver faulty results. Frequently, if not always, such behavior is blamed the lack of a complete requirements specification. hi this assertion, it is tacitly understood that if a specification is correct and comprehensive enough then it is possible to avoid computing erro

The diffusion of digital technologies has strongly affected the way scholars and researchers use and perceive the archaeological information detected during the field investigation process. Archaeologists are still only beginning to realize the full potential of these applications beyond the attraction of providing visually engaging documentation and focus on the analytical and interpretive power.

Popular Abstract in Swedish Denna avhandling syftar till att ge en översikt över cirka hundra år av europeisk intellektuell historia som lyfter fram nya aspekter av de klassiska tänkarna. Analysen av de fyra filosoferna Thomas Hobbes, John Locke, David Hume och Charles de Montesquieu syftar till att belysa en generell historisk process, nämligen hur den moderna människosynen växer fram i Europa. EThis essay has three main aims. The first one is to give an overview of some hundred years of European intellectual history, bringing out new aspects of the classical thinkers. The analysis of the four philosophers Thomas Hobbes, John Locke, David Hume and Charles de Montesquieu aims at illustrating a general historical process, viz. the emergence of the modern view of man in Europe. After Hobbes,

Popular Abstract in English Figure 1: Electron microscopy image of mesoporous material seen from above. The left image shows a possible shape of a silica particle (scale bar: 1 μm). The right image shows the mesopores in the particle (grey color) with the silicon dioxide walls (black color) (scale bar: 150 nm). Poly(N-isopropylacrylamide) (PNIPAAM) is a polymer that can provide the active part forMesoporous silica materials, such as SBA-15, have potential as biocompatible carriers for pharmaceutical applications as well as mini-reactors in e.g. catalysis. This potential arises from their well-defined porous structure on the nanometre scale accompanied by a high internal surface area (800 - 1000 m2/g). This work addresses the following issues. i) Surface grafted PNIPAAM was found to be loca