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Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals—a Swedish population-based study

Background: Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compare

Biomarkers of exposure in environment-wide association studies – Opportunities to decode the exposome using human biomonitoring data

Background: The European Union's 7th Framework Programme (EU's FP7) project HEALS – Health and Environment-wide Associations based on Large Population Surveys – aims a refinement of the methodology to elucidate the human exposome. Human biomonitoring (HBM) provides a valuable tool for understanding the magnitude of human exposure from all pathways and sources. However, availability of specific bio

Figurative, Transferred or Extended use? : The Use of Semantic Labels in the First Edition and the Revised Version of the Swedish Academy Dictionary

In this paper, a doctoral study on the description of semantic change in the Swedish Academy Dictionary (SAOB) is presented. The starting point for the study is semantic labels like figurative and in extended use. Five such labels in SAOB are examined, mainly with methods from the cognitive linguistic framework. The results show, among other things, that the most labelled mechanism is metaphor, th

Asynchronous Real-Time Federated Learning for Anomaly Detection in Microservice Cloud Applications

The complexity and dynamicity of microservice architectures in cloud environments present substantial challenges to the reliability and availability of the services built on these architectures. Therefore, effective anomaly detection is crucial to prevent impending failures and resolve them promptly. Distributed data analysis techniques based on machine learning (ML) have recently gained attentionThe complexity and dynamicity of microservice architectures in cloud environments present substantial challenges to the reliability and availability of the services built on these architectures. Therefore, effective anomaly detection is crucial to prevent impending failures and resolve them promptly. Distributed data analysis techniques based on machine learning (ML) have recently gained attention

Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis

Background: Juvenile idiopathic arthritis (JIA) is a rheumatic disorder that causes chronic joint inflammation beginning before the age of 16 years. Pharmacological treatment necessary to prevent joint destruction and functional impairment includes non-steroidal anti-inflammatory drugs (NSAIDs), intra-articular corticosteroids, conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DM

Perioperative systemic chemotherapy in peritoneal carcinomatosis of lymph node positive colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal carcinoma. Patients with positive lymph node status have worse survival after CRS-HIPEC, which is probably due to higher rates of systemic failure. In this study, we analysed the effect of administration and timing of systemic chemot

Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma

Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Sever

Soviet Espionage in Sweden : The Vasilii Sidorenko Case of 1942

This is a study of a Soviet espionage mission in Sweden in 1942 under the aegis of the intelligence officer Vasilii Sidorenko. Aside from trying to reconstruct, on the basis of material filed with the archive of the Swedish Security Police (Säpo), the history of the mission, the article also addresses methodological challenges following from the fact that we must, as Soviet material remains very s

Precise characterisation of HD 15337 with CHEOPS: A laboratory for planet formation and evolution

Context. The HD 15337 (TIC 120896927, TOI-402) system was observed by the Transiting Exoplanet Survey Satellite (TESS), revealing the presence of two short-period planets situated on opposite sides of the radius gap. This offers an excellent opportunity to study theories of formation and evolution, as well as to investigate internal composition and atmospheric evaporation. Aims. We aim to constrai

Gammalt möter nytt: SVT Nyheter, artificiell intelligens och migrationsperspektiv.

Migration has been a contested issue in Swedish politics over the past decade, and media coverage has repeatedly sparked debate about the impartiality of Sveriges Television (SVT). Using large language models (LLMs) as coding instruments, this study examines how migration has been framed in SVT Nyheter, a major Swedish public service news outlet, between 2014 and 2024. Rather than explaining causa

Strengthening the global surgical workforce: Aspects of access, migration and quality

Background. Over five billion people worldwide lack access to safe and affordable surgery and anesthesia care when required. There is a critical unmet need for surgical care, especially in low-income and middle-income countries (LMICs). The shortage of surgical providers is one of the most influential barriers to receiving surgical care, and the maldistribution is aggravated by doctors emigrating

Making space in the city for diverse life worlds and temporalities : An explorative investigation of the affordance and territoriality of urban cemeteries

The urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The resThe urban cemetery is a built green environment that is both a place of death, belonging to the bereaved and their rituals of care and remembrance, and a recreational space, where people rest, walk their dog, jog, reflect in silence, or just pass through. Urban cemeteries and urban parks share some features and uses in that respect, but they also have very different meanings and functions. The res

Risk of non-fatal suicide attempt in individuals with substance use disorder : the roles of aggregate genetic liability and environmental exposures in a Swedish population-based cohort

Background and Aims: Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past-year env

Spreading knowledge about nature conservation - Are we forgetting the machine operators?

Maskinförarnas roll I naturvårdsarbetet Både den Europeiska unionen och den Svenska regeringen ser evidensbaserad praktik och allmän medvetenhet som avgörande för naturvårdsarbetets utveckling. När myndigheter genomför naturvårdsprojekt, måste de anställa maskinentreprenörer genom offentlig upphandling. Men det finns inget sätt för myndigheterna att kräva hög kompetens inom naturvårdsarbete i denBoth the European Union and the Swedish government consider the need for evidence-based practice and public awareness crucial in nature conservation work. When authorities perform nature conservation projects, they need to hire machine contractors through public procurement. However, there is no way for the authorities to demand high competence in nature conservation work in the public procurement