Filtyp
Cancer of unknown primary (CUP) is a heterogeneous syndrome diagnosed at metastatic sites. The etiology is unknown but immune dysfunction may be a contributing factor. Patients with autoimmune diseases were identified from the Swedish Hospital Discharge Register and linked to the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for subsequent CUP and compared with subj
Testicular germ cell tumours (TGCT) exhibit remarkable ability to differentiate into virtually all somatic tissue types. In this study, we investigated changes in mucin-type O-glycosylation, which have been associated with somatic cell differentiation and cancer. Expression profile of simple mucin-type O-glycans (Tn, sialyl-Tn, T), histo-blood group H and A variants and six polypeptide Ga1NAc-tran
In a warming climate, permafrost is likely to be significantly reduced and eventually disappear from the sub-Arctic region. This will affect people at a range of scales, from locally by slumping of buildings and roads to globally as melting of permafrost will most likely increase the emissions of the powerful greenhouse gas methane, which will further enhance global warming. In order to predict fu
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf
An unlimited number of proteolytic reactions are carried out by enzymes in biological systems. These enzymes are a necessity of life, but they can also be dangerous if they are not controlled. Protease inhibitors regulate proteolytic enzymes by interacting and forming complexes with them, thereby preventing the substrate from gaining access to the active site of the enzyme. We have recently identi
The present study addresses the question why there is a positive relationship between nitrogen deposition and potential net nitrogen mineralisation and nitrification in oak (Quercus robur L.) forest soils in south Sweden (Falkengren-Grerup et al., 1998), and how this is related to the carbon mineralisation. We tested three hypotheses based on European studies (Persson et al., 2000a,b) that postula
Popular Abstract in SwedishDenna avhandling handlar om kvinnor i missbrukarbehandling och deras beskrivningar av sig själva som kvinnor, den s.k. femininitetsprocessen. Syftet är att beskriva och försöka förstå behandlingens betydelse i kvinnornas femininitetsprocesser och vilken innebörd rusmedel, män, den egna kroppen, moderskap och sexualitet har och har haft däri. Avhandlingen har huvudsakligeThis thesis is about women in drug abuse treatment and their descriptions of themselves as women - their process of becoming feminine. The aim of the thesis is describing and trying to understand the meaning of the treatment in the women's femininity processes and what significance drugs, alcohol, men, the own body, motherhood, and sexuality have and have had in the process. The emphasis is on the
Popular Abstract in Swedish Våtmarker är en naturtyp som man finner i övergångszoner mellan land och vatten. Idag talas det mycket om våtmarkers positiva natur- och miljövärden i avrinningsområden i det moderna jordbrukslandskapet. Våtmarker ger omväxling i landskapet och är viktiga biotoper för växter och djur. I våtmarker ansamlas mycket dött växtmaterial och tillsammans med en god tillgång på vIn this thesis, I have studied nitrogen turnover processes in watermeadows. A watermeadow is a wetland where water infiltrates through the soil of a grassland field. It is hypothesized that infiltration of water through the soil matrix promotes nutrient transformations compared to surface flow of water, by increasing the contact between water, nutrients, soil organic matter and bacteria. I have st
We investigated the mechanism of lysosome-mediated cell death using purified recombinant pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line NT2, Potential effectors were either isolated lysosomes or purified lysosomal proteases. Purified lysosomal cathepsins B, H, K, L, S, and X or an extract of mouse lysosomes did not directly activate either recombinant c
Helicobacter pylori attaches via lectins, carbohydrate binding proteins, to the carbohydrate residues of gastric mucins. Guinea-pigs are a suitable model for a H. pylori infection and thus the carbohydrate composition of normal and H. pylori infected gastric mucosa was investigated by lectin histochemistry. The stomach of all infected animals showed signs of an active chronic gastritis in their mu
Ectomycorrhizal (EM) fungi are known to colonize minerals in forest soil, and in many laboratory experiments it has been confirmed that EM fungi stimulate dissolution of minerals such as apatite, biotite and feldspars. However, due to the low number of experiments performed in the field, and in forests with different soil fertilities, it is difficult to conclude whether this effect has any ecologi
The SNP rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein. Autoantibodies (Ab) that recognize ZnT8R, ZnT8W or both at the polymorphic site are common in newly diagnosed type 1 diabetes (T1D) patients. The epitope specificity and affinity of ZnT8Ab are poorly understood, but may be of importance for the pred
Avian communities play a pivotal role in Arctic ecosystems and birds have become the key model taxa for climate change research. Due to funding priorities, Arctic passerines have been studied less intensively than waterfowl and shorebirds. In our study, we aim to partly fill this gap and look at the change in passerine community species composition in the Chaun River Delta in Northeast Siberia (68
Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue for whole-body energy homeostasis, the effect of AMPK activation in adipocytes has only been studied to a limited extent and mainly with the AMP-mimetic 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside (AICAR), which has limited
This paper demonstrates a method to transform and link textual information scraped from companies' websites to the scientific body of knowledge. The method illustrates the benefit of Natural Language Processing (NLP) in creating links between established economic classification systems with novel and agile constructs that new data sources enable. Therefore, we experimented on the European classifi
Antivirals for HPV infection Human papillomaviruses (HPV) are present in more than 99% of all cervical cancers and HPV-16 is one of the predominant types of HPV infections and account almost for 50% of cervical cancer cases. Although two vaccines are available on the market and showed notable promising in HPV prevention, there are still no available antiviral drugs for HPV infections. In this stu
As CO2 builds up in the atmosphere causing global climate change (IPCC, 2022) trees have become an international symbol of combatting this, and for good reason. Trees take up CO2 which as a result combats these changes, and when these trees are cut down fewer individuals remain to take up the CO2 that we humans emit (Chapin et al., 2011). This means that clear-cut areas don’t act as the carbon sin
Under de senaste fem åren har olika ekonomiska faktorer som påverkar bostadssituationen i Sverige ökat avsevärt, med skyhöga elpriser, bostadräntor och en hög inflation bl.a. Läget har gjort det omöjligt för främst unga, äldre eller människor i utanförskap att införskaffa en egen bostad. Samtidigt är landet ett av de länder som har flest ensamboenden i sina städer, vilket är en stor orsak till psyOver the past five years, various economic factors affecting the housing situation in Sweden have significantly increased, including skyrocketing electricity prices, housing interest rates, and high inflation, among others. This situation has made it impossible for primarily young people, the elderly, or individuals facing social exclusion to acquire their own homes. At the same time, the country
Study purpose: This study explores how Floating Container Terminals (FCTs) located in the North and Baltic Seas can support the maritime shipping industry's growth while promoting sustainability. As freight transportation volumes rise and sustainability regulations tighten, ports face increasing demands to accommodate Ultra-Large Container Vessels (ULCVs) in an environmentally responsible mann
