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Mutation tolerance in cell models with manipulated osteosarcoma-genes

Vilket protein vaktar arvsmassan bäst? Osteosarkoma är den mest förekommande elakartade bentumören. Den drabbar unga under 25 år och framförallt när de når puberteten. Tekniska framsteg och aggressiv behandling inom tumörsjukdomar har gjort att vi idag har en förväntad överlevnad på ungefär 60-70 % , en siffra som kan och måste förbättras. Det är viktigt att forskningen trappas upp så att alla ba

'Dangerous Beauty' : a feminist analysis of the U.S. and the U.K. media’s portrayal of female soldiers through the case of Private First Class Lynndie England

Syftet med denna uppsats är att förstå hur, och varför, media upprätthåller traditionella könsnormer i deras porträttering av kvinnliga soldater. Studiens primärmaterial består av artiklar publicerade av tidningar i USA och Storbritannien, som beskriver menig Lynndie England och hennes handlingar i Abu Ghraib-skandalen. För att uppnå syftet med denna studie ställs följande frågeställningar: På vilThe aim of this thesis is to understand how, and why, the media is sustaining traditional gender norms in their portrayal of female soldiers. The primary material of the study consists of articles published by newspapers in the United States and the United Kingdom, describing PFC. Lynndie England and her actions in the Abu Ghraib scandal. To meet the purpose, the thesis addresses the following res

How to provide a humanitarian warehouse location model with data - An assessment of scenario creation and data availability at the United Nations High-Commissioner for Refugees (UNHCR)

I slutet av 2014 hade 38 miljoner människor runt om i världen flytt sina hem till följd av krig, konflikt och våld. Att rädda liv och minska lidandet för dessa flyktingar är syftet med humanitärlogistik. Beredskap en nyckelroll i humanitära organisationer eftersom det är ett verktyg för att minska det negativa genomslaget av framtida händelser. En vanlig beredskapsåtgärd är att så kallad för-positAt the end of 2014, 38 million people around the world had fled their homes due to man-made disasters such as war, armed conflict and violence. To save the lives and alleviate the suffering of these refugees and displaced is the purpose of Humanitarian Logistics. Preparedness is of key importance in humanitarian organisations as it is a tool to reduce the impact of coming events. One common prepar

En grönare järnväg

Detta arbete är en utredning av hur järnvägskonstruktionens emissioner ser ut vid anläggning. Den samlade datan har översatts i ett matematiskt uttryck som ger ett minsta årtal för när en neutraliseringshorisont för projektet kan nås. De resulterande uttrycken som studien tagit fram ger approximativa värden baserat på de studier av utsläpp och energiresurserna som innefattas vid järnvägskonstruktiThis thesis is an analysis of what the amount of emissions from railway constructions could look like, the resulting analysis is translated through an equation that concludes by giving the reader a minimum of years before a neutralization horizon is achieved. The result is based upon the variable input from the described data and depicts an approximate value that by itself aims to add to the trans

Legal Dimensions of Video Game Modding- A Comparative Analysis of EU, US, and International Legal Frameworks

This thesis investigates the legalities surrounding the creation of modifications (mods) for video games, focusing primarily on European Union law with comparisons to U.S. and international legal frameworks. The subject matter addresses how user-generated content, such as game mods, interacts with copyright laws and the challenges that arise in the digital era. The purpose of the study is to exami

Expertise and Performative Legitimation in Consumer-led Governance Initiatives: - A Case Study of GoodWeave India

The following thesis is an attempt to critically analyse the legitimation claims of Private Transnational Governance (PTGs) initiatives targeting child labour in the Indian carpet belt. Drawing upon the concept of performativity, the research will seek to problematize the tendency to perceive legitimacy in the myopic sense of quantifiable ‘inputs’ and ‘outputs’. To address this issue, the study wi

Investigating the effect of Aβ overexpression on tau phosphorylation

The breakdown of neuronal networks and synaptic degeneration are responsible for the memory impairment associated to Alzheimer’s disease (AD). Amyloid-β (Aβ) and tau are the two proteins that have been identified as the hallmarks for pathological changes found in the brain of Alzheimer’s patients. These two hallmarks have been extensively studied separately, but how they relate to each other and t

Deepfakes as a commercial and creative tool within strategic communication

It is a huge challenge for any strategic communicator to reach its audience as they are constantly overwhelmed with information. A current trend is to create so-called deepfakes, where a photo, audio, or video can be manipulated while making it feel authentic. Although it is an effective way to engage and entertain that has become increasingly popular, it has also received a lot of criticism as it

Towards Sustainable Manufacturing of Preterm Labor Treatment Drug Atosiban

Peptidbaserade läkemedel utgör en växande del av läkemedelsindustrin, med behandlingsmöjligheter mot en bredd av sjukdomar. Det första peptidbaserade läkemedlet var insulin som introducerades under 1920-talet, sedan dess har applikationer av peptidläkemedel ökat, och tillverkningsmetoder utvecklats. Under 1960-talet introducerades fastfaspeptidsyntes (solid phase peptide synthesis, SPPS), där peptMethods for synthesis of peptides using solid phase peptide synthesis (SPPS) are hampered by relying on large amounts of hazardous substances such as dimethylformamide (DMF) as solvent for peptide assembly and trifluoroacetic acid (TFA) a per/polyfluoroalkyl substance (PFAS) as reagent/solvent for side chain protecting group (PG) removal and peptide resin cleavage. Advances have been made towards

Arbetstagares rättigheter i en AI-driven arbetsmiljö: AI-förordningen på svensk arbetsmarknad.

This paper examines how Artificial Intelligence (AI) and the AI-act affect the rights of the employee within the Swedish labour market, focusing on integrity. By analyzing different perspectives of the labour market´s AI-use the aim is to understand how employee rights are accommodated. The adjustment due to the AI-act attribute to the understanding of changing labour market conditions related to

Unveiling Justice: A Critical Study of the French Restrictive Policy on the Veil A Multifaceted Examination of Muslim Women’s Human Rights

This thesis explores the relationship between French restrictive policies on the hijab and burqa and their impact on the human rights and fundamental freedoms of Muslim women. It likely delves into the historical context of these policies, analyses the legality and implications of such restrictions, and considers the broader sociocultural and political factors at play. It further examines the inte

Development of Pheromone-Based Mating Disruption for Three Lepidopteran Pests of Currant in Northern Europe

Currant, and in particular blackcurrant, Ribes nigrum, is widely grown in Europe. It is the host of a number of pest insects, but their occurrence and the damage they cause vary geographically. In northern Europe, three lepidopteran species, the currant shoot borer (Lampronia capitella), the currant clearwing (Synanthedon tipuliformis), and the currant bud moth (Euhyponomeutoides albithoracellus),

Bolt fixings in toughened glass

Research needs: Glass has been used for a long time, mostly in the window and packaging industry, but lately architects and design engineers have become more and more interested in glass as a load-bearing (building) material. It has become a challenge to use less other materials in the glass-structures or at least not to let it show too much. One area of big interest is bolt fixings. Design engine

Integritet, sociala medier och arbetsrättsliga sanktioner

Uppsatsen behandlar gällande rätt rörande arbetstagarens integritet och kravet på dennes lojalitet inom svensk arbetsrätt. Rätten som den ser ut idag ställs mot de nya problem som uppkommit efter Internet och så kallade sociala mediers intåg på den svenska arbetsmarknaden. Integritetsfrågor har länge varit intressant på den svenska arbetsmarknaden och har influerats av arbetet inom den europeiskThe thesis deals with the current Swedish legislation concerning the employee’s right to personal integrity and the need for his loyalty in the Swedish labour law. Modern day law is faced with the new problems that arose after the inmarsch of Internet and the so called social media into the Swedish labour market. The matter of integrity in the Swedish labour market has been of great interest for

Keeping Cash Clean - The Reporting Regime and Possible Adverse Effects

Financial services and cross-border financial activities have developed considerably due to the globalisation of the economy. The utilisation of these new opportunities has, however, attracted financial activities that relates to money laundering. Money laundering is a way to separate and conceal the proceeds of crime in order to reinvest or simply use it in the open economy, without drawing the a

The exclusion from protection of functional shapes under the trade mark law of the EU

Article 4 of the Community Trade Mark Regulation (CTMR) defines signs of which a Community trade mark may consist in a very wide manner, expressly including the shape of goods or of their packaging. However, with regard to such shapes, the Regulation in its Article 7(1)(e) introduces a, in comparison with other signs, additional ground for refusal that has to be overcome when seeking registration.

Kreativitet kan både initieras, vårdas och utvecklas.

Syfte; Vårt syfte med studien är att lära oss om man kan styra ett kreativt beteende och i så fall vilka faktorer som kan påverka detta, dels beroende på företagets styrmedel och dels förhållandet mellan individ och grupp. Metod: Studien är en kvalitativ studie med ett induktivt förhållningssätt i form av en fallstudie där vi under en period hösten 2011 studerade ett företag inom distanshandel. Ut

Challenges in Sustainability Vision Communication: Towards a framework for challenges in internal sustainability vision communication

Sustainability is increasingly a matter of key strategic importance for organisations across all sectors as stakeholders from all directions are demanding it as the "new normal". Consequently, organisations worldwide are incorporating sustainability into their business operations. A shared sustainability vision among internal stakeholders can provide the necessary guidance to develop via

HfO2-based memristive synapses with asymmetrically extended p-n heterointerfaces for highly energy-efficient neuromorphic hardware

The escalating energy consumption of existing artificial intelligence hardware has become a serious global issue that demands immediate action. Neuromorphic computing offers promises to drastically reduce this footprint. Here, we introduce multicomponent p-type Hf(Sr,Ti)O2 thin films for energy-efficient, resistive switching–based neuromorphic devices. We demonstrate interfacial memristors with ul