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We investigated the mechanism of lysosome-mediated cell death using purified recombinant pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line NT2, Potential effectors were either isolated lysosomes or purified lysosomal proteases. Purified lysosomal cathepsins B, H, K, L, S, and X or an extract of mouse lysosomes did not directly activate either recombinant c

Popular Abstract in Swedish Många växtarter kan inte kolonisera kalkjordar och det är stora skillnader i artsammansättningen mellan kalkjordar och närliggande surare jordar. Detta beteende kallas ofta för kalkskyende och tycks orsakas av en oförmåga hos dessa växtarter att lösa och ta upp fosfat och järn ur kalkjordar. Kalkjordar innehåller mycket låga halter av järn och fosfat löst i marklösningeMany vascular plant species are unable to colonise calcareous sites, the floristic composition of adjacent limestone and acid silicate soils differing markedly. The inability of these 'calcifuge' species to establish themselves and grow on limestone soil appears to mainly be related to their low capacity for solubilising and absorbing phosphate and/or iron from such soils. Differences between calc

This symposium presents two tracks, one practical and one more theoretical, divided in ten topics, and presented in three parallel sessions. Two new topics are introduced; “Historical Buildings” and “Challenges for the future”. The intention of adding Historical Buildings is to gather people with different backgrounds, for example Building Physicists, Building antiquarians, Building Biologists, Ar

Ectomycorrhizal (EM) fungi are known to colonize minerals in forest soil, and in many laboratory experiments it has been confirmed that EM fungi stimulate dissolution of minerals such as apatite, biotite and feldspars. However, due to the low number of experiments performed in the field, and in forests with different soil fertilities, it is difficult to conclude whether this effect has any ecologi

The SNP rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein. Autoantibodies (Ab) that recognize ZnT8R, ZnT8W or both at the polymorphic site are common in newly diagnosed type 1 diabetes (T1D) patients. The epitope specificity and affinity of ZnT8Ab are poorly understood, but may be of importance for the pred

Antivirals for HPV infection Human papillomaviruses (HPV) are present in more than 99% of all cervical cancers and HPV-16 is one of the predominant types of HPV infections and account almost for 50% of cervical cancer cases. Although two vaccines are available on the market and showed notable promising in HPV prevention, there are still no available antiviral drugs for HPV infections. In this stu

A part of the project of transforming the worn down medieval fortress Glimmingehus into a tourist attraction for the people of the 20th century, was to dig out the once filled in moat surrounding it. This very labour intensive project did not only result in a nostalgic atmosphere but also a large amount of fairly well preserved finds, since the moat had once been used as a rubbish dump. A part of

Effekterna av mikroplaster är ännu inte helt utredda och därför kan de vara mycket farligare än vad vi vet idag. Plastpartiklarna kan finnas överallt i miljön och en hittills outforskad spridningskälla är deponier och dess lakvatten. Det har inte undgått allmänheten att större plastskräp, det vill säga makroplaster, både förfular samt förstör natur och miljö. Mindre plastskräp, så kallade mikropAlthough most microplastics (<5 mm in length or diameter, depending on shape) are not visible they can be found everywhere in the environment. The effects can be devastating and much greater than what has been proven so far, as there is a lack of knowledge about the impact, spread and extent of microplastics. The Swedish EPA published a report in June 2017 which reveals a number of major microplas

Lakvatten läcker ut mikroplast Effekterna av mikroplaster är ännu inte helt utredda och därför kan de vara mycket farligare än vad vi vet idag. Plastpartiklarna kan finnas överallt i miljön och en hittills outforskad spridningskälla är deponier och dess lakvatten. Det har inte undgått allmänheten att större plastskräp, det vill säga makroplaster, både förfular samt förstör natur och miljö. MindrAlthough most microplastics (<5 mm in length or diameter, depending on shape) are not visible they can be found everywhere in the environment. The effects can be devastating and much greater than what has been proven so far, as there is a lack of knowledge about the impact, spread and extent of microplastics. The Swedish EPA published a report in June 2017 which reveals a number of major microplas

Uppsatsen utvärderar och undersöker effekterna av den svenska regleringen gällande särskilda transaktionsavtal, s.k. budrelaterade arrangemang. Detta genom att undersöka regleringens effekt på den svenska kapitalmarknaden och målbolagsaktieägare. Grunderna för den svenska takeoverregleringen presenteras genom att undersöka de relevanta bestämmelserna i, och förhållandet mellan, aktiemarknadsrätt, The thesis evaluates and examines the effects of the Swedish regulation of deal protection arrangements by looking to the impact of the provision on the Swedish capital market and target shareholders. The foundations of the Swedish takeover regulation are examined by presenting and arguing the relevant provisions in, and relationship between, stock exchange law, corporate law and EU law. Fiduciar

Save the world with Trichoderma Today a lot of people are talking about the health benefits of consuming probiotics and the importance of having a good gut biome, but did you know that this is also be true for plants? A lot of people may have heard about the beneficial effect of mycorrhizal fungi and nitrogen fixing bacteria, but few have heard about Trichoderma. The fungus Trichoderma is a her

Title: Can new companies be in a position to save the world? A qualitative study in how small, newly started companies, with an expressed focus on sustainability, work operatively in their supply chain. Seminar date: 31st of May 2018 Course: FEKH99, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 University Credits Points (UPC) or ECTS Authors: Alexandra Karas

Due to a warming climate, tundra ecosystems are subject to shrub and treeline expansions which could lead to increased above- but decreased belowground carbon (C) stocks. An observed low soil C stock in some subarctic forests and tall shrublands has been suggested to be induced by priming of organic matter decomposition, possibly mediated by ectomycorrhizal fungi. On the other hand, the higher bel

Det huvudsakliga syftet med denna uppsats är att undersöka om ett fullgott juridiskt ramverk i syfte att skydda den arktiska regionen redan är etablerat, eller om ytterligare juridiska instrument behöver tillkomma för att så ska vara fallet. Frågan diskuteras med bakgrund av det faktum att den arktiska isen smälter i en hög takt, och att framtiden för regionen sannolikt kommer att se väldigt annorThe main purpose of this thesis is to examine whether or not the legal framework to govern the Arctic can be said to be in place already, or if additional judicial measures need to be taken, given the future that awaits the region as a result of the ongoing rapid ice melt. For many decades, or even centuries, it was the common perception that the Arctic would remain permanently ice-covered, and be

En bergartsmagnetisk studie har utförts på en guldmineralisering som är belägen vid Åkerberg, 30 km Nordöst om Boliden, i norra Sverige. Mineraliseringen är bunden till en zon av subparallella kvartsgångar i en magmatiskt lagrad gabbro. Markbundna totalfältsmätningar av magnetismen visar en negativ anomali över malmzonen. I detta arbete har de magnetiska egenskaperna av området kring malmen, samt

Under de senaste 100-200 åren har tall (Pinus sylvestris) etablerats på många sydsvenska mos- sar. Eftersom tall trivs i relativt torra och näringsrika miljöer, ger detta en indikation på att grundvattennivån i mos- sarna har sänkts. Tre mossar i Kronobergs län, Småland, har valts ut för en dendrokronologisk och torvstratigrafisk undersökning för att se om det finns ytnära torvlager som vittnar omScots pine (Pinus sylvestris) can be found growing in many raised bogs in Småland, south Sweden, and these trees have been established during the last 100-200 years. Because pine prefers a relatively dry environment rich in nutrients, its presence indicates a lowering of the groundwater table. Three bogs in south Sweden were in- vestigated with dendrochronologic and peat stratigraphic methods to d

Rationalisering av arbetsmiljön i häststallar - Tävlings- och avelsstall Hästsektorn i Sverige idag håller på att växa och nästan 10 % av Sveriges befolkning kommer regelbundet i kontakt med hästar. Intresset för dessa djur ökar hela tiden, vilket innebär att allt fler människor även kommer att komma i kontakt med den dagliga skötseln av hästen. Vid skötseln av hästarna är tunga lyft och andra påfThe Horse Sector in Sweden today is growing and almost 10% of Sweden's population will be regularly in contact with horses. Interest in these animals is increasing all the time, which means that more people will also get in touch with the daily care of the horse. In the management of horses is heavy lifting and other strenuous movements regular. Something that has been overlooked in the horse

The main goal of the project was to decrease the cooling time of a diamond anvil cell (DAC) by modifying an existing design. Modifications included change of materials, overall dimensions and a significant reduction of mass together with additional suggestions for decreased cool time. The initial design was known to function with current materials and dimensions. The first step of the thesis was

Syfte: Uppsatsen syfte är att utöka förståelsen kring huruvida fakulteter vid ett universitet arbetar med sin märkesidentitet med hjälp av internal branding för att differentierar sig i en värld där konkurrensen hårdnar och ackrediteringar riskerar att likforma fakulteterna. Metod: En kvalitativ studie har genomförts med ett hermeneutistiskt fenomenologiskt förhållningssätt. Den analys och slutsaPurpose: The purpose of this thesis is to bring awareness whether the faculties at the universities is working with its brand identity by using internal branding in order to differentiate themselves, in a world where competition is intensifying and where accreditations threaten to uniform the faculties. Methodology: A qualitative study has been conducted with a hermeneutic phenomenological approa