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BACKGROUND. In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa. We characterized the substrate specificity and zinc-mediated inhibition of PSA. METHODS. The proteolysis of human semenogelin I (SgI) and II (SgII) by PSA was characterized by purification of generated SgI and SgII fragments, N
IntroductionThe interest in Para athletes’ health continues to increase. Still, there are few studies that have evaluated health parameters beyond injury and illness in this athlete population.ObjectiveTo assess: i) the weekly proportion of elite Para athletes reporting anxiety/depression, low sleep levels (≤7 hours) and pain over 52 weeks and; ii) and to explore whether these health parameters ar
The market for electric bicycles has grown extremely and developed rapidly in recent years. To enter such a market with a new product, the development process has to be fast, and throughout the process, feedback from future potential customer(s) should be sought in order to achieve the best possible market acceptance. The article presents the design process of a pedelec e-bike central drive system
Young people, who previously have been placed away from home in foster care, are from the political perspective, a particularly vulnerable group. This is a very general manner that previously placed young people live or has lived more volatile and turbulent, with changing within education and very poor self-management, What these peoples experience when they enter the independent adulthood is an a
Samhället befinner sig i ett skede där 80-talisterna med deras värderingar och attityder gör sitt inträde på arbetsmarknaden och där 40-talisterna, redan börjat lämna arbetslivet och går i pension. Uppsatsen redogör för de värderingar och attityder som teorin belyser att 80-talister har, för att sedan urskilja de grundläggande värderingarna som vi anser sammanfattar bilden av generationen. Grundvä
Colorectal cancer is the third most common cancer type in the western world. in search of new treatment possibilities, the inflammation mediators, know as cysteinyl leukotrienes (CysLTs), have been shown to regulate intestinal epithelial cell survival and proliferation via the CysLT(1)R, and cell differentiation via the CysLT(2)R. These results prompted us to investigate the significance of CysLT(
1. To help meet the requirements of water legislation, palaeolimnology has been widely used to establish ‘reference conditions’ and restoration targets for lakes. However, its potential for assessing the necessity and appropriateness of different lake management activities has been less publicized. 2. With reference to selected case studies covering consultancy projects commissioned by UK conserv
Moving forward, higher education will face a variety of challenges, especially in 2020/2030, due to technological development and digitalization. Digitalization in society has grown, and society fosters digital citizenship to a greater extent. Students entering higher education today have grown up with the Internet and mobile devices. Daily life, schools, and work have also become more mobile beca
EPR spectroscopy has proven to be an indispensable tool in elucidating the structure of metal sites in proteins. In recent years, experimental EPR data have been complemented by theoretical calculations, which have become a standard tool of many quantum chemical packages. However, there have only been a few attempts to calculate EPR g tensors for exchange-coupled systems with more than two spins.
Uppsåtsinvändningen om sexsomni har på senare år blivit alltmer förekommande på straffrättens område. Invändningen innebär att den tilltalade gör gällande att den sexuella handlingen som hen står åtalad för har företagits i sömnen och att uppsåt därmed saknats. Om inte åklagaren lyckas motbevisa invändningen frias den tilltalade således från ansvar. En av de faktorer som tyder på att gärningen fakThe objection of intent in the case of sexsomnia has become increasingly more common in criminal law in recent years. Under this objection, the defendant argues that the sexual act for which he or she is charged with was undertaken in his or her sleep and that there was therefore no intent. Unless the prosecutor succeeds in refuting the objection, the defendant is thus acquitted of responsibility.
En viktig utgångspunkt i straffrätten är det individuella ansvaret. Människor begår däremot ofta brott tillsammans. Denna uppsats handlar hur det straffrättsligt bör hanteras när flera personer begår brott gemensamt. Syftet med uppsatsen är att behandla den rubriceringsproblematik som kan uppstå när en tilltalad står åtalad för ett brott som är begånget i gemenskap. Begreppslig klarhet är genomgThe foundation of Criminal liability is the condition that everyone is responsible for their own actions, and those actions alone. People however, often commit crime together. This thesis deals with criminal liability when people commit crime as a collective. With the aim of conceptual clarity, the purpose of this essay is to process the classification problem that may arise when a defendant is
Intresset för probiotika har vuxit de senaste åren. Förutom att vara ha en förebyggande effekt och vara en effektiv behandling mot akut diarré, finns det forskning som indikerar att probiotika kanske kan användas för att förebygga andra sjukdomar, t.ex. tjocktarmscancer. Utmaningen med probiotika är att för att den ska ha någon effekt, krävs det att tillräckligt många levande bakterier når tjocktaThe interest in probiotics has grown in the last few years. In addition to being effective in treating and preventing acute diarrhea, there are indications that it might be possible to use probiotics to prevent other diseases such as colon cancer. The challenge with probiotics is that for it to have any effect, enough viable bacteria must reach the colon. To deliver live probiotics to the colon, i
Denna uppsats behandlar frågan om när det är berättigat att kriminalisera. Utgångspunkten har varit liberal straffrättsteori och studieobjektet har varit kriminaliseringen av narkotikabruk i Sverige. I uppsatsen undersöker jag huruvida de skäl som anfördes vid kriminaliseringen av narkotikabruk kan berättiga densamma utifrån relevanta principer från den liberala straffrättsteorin. Den liberala stThis thesis concerns the issue of when it is legitimate to criminalize. The study focuses on the criminalization of drug use in Sweden and examines whether the criminalization can be justified using criteria from the liberal criminal theory. The liberal criminal theory advocates a restrictive use of criminal law and it states that criminalization as a method for preventing unwanted behaviors oug
Åtkomst till bevismaterial är avgörande för att förverkliga det straffrättsliga ansvaret. Idag är en stor del av detta bevismaterial digitalt och i syfte att skydda och hemlighålla sådan information används i allt större utsträckning kryptering. Kryptering, som enklast möjligt kan sägas utgöra den digitala versionen av att låsa in material i ett kassaskåp, innebär att man utan den särskilda dekrypBeing able to access evidence is crucial for the realisation of responsibility under criminal law. In today’s world, a large part of what can potentially be evidence is stored digitally. In order to protect and keep digital information confidential, encryption is becoming widespread. Encryption, put simply, can be said to be the digital version of locking material in a safe, and basically means th
Tetra Pak is a large scale organization that provides its customers with a food packaging solution based on laminated carton board in various package formats. The packaging material is produced in more than 50 converting factories represented world wide. The production develops the material in roll form that are loadable in the filling machines. Each roll arrives to the filling site with a barcode
Malignant melanoma of soft parts (MMSP), also called clear cell sarcoma of tendons and aponeuroses, is cytogenetically characterized by the t(12;22)(q13;q12) resulting in the chimeric EWSR1/ATF1 gene. MMSP shares a number of morphologic, histologic, and immunohistochemical features with malignant melanoma of the skin, causing diagnostic difficulties in the distinction between MMSP and metastatic m
Objectives: Carotid stenosis is a crucial cause of ischemic stroke. Recent studies suggest that one of the most important effects of lipid-lowering statins is to stabilize vulnerable plaques. However, it remains to be determined if this effect is secondary to the lowering of plasma cholesterol levels or due to a direct effect of statins on plaques stability. Design and main outcome measures: In th
Antigenic variation in microbial surface proteins represents an apparent paradox, because the variable region must retain an important function, while exhibiting extensive immunological variability. We studied this problem for a group of streptococcal M proteins in which the similar to 50-residue hypervariable regions (HVRs) show essentially no residue identity but nevertheless bind the same ligan
This paper presents the results from an osteological method study of the Ringsjöholm fishbone material. Ringsjöholm is located in Scania, southern Sweden and is 14C dated to 5960-5200 B.P. The aim of this paper is to critically analyse methods used on fish bone material in estimations of season. Three different approaches were used to estimate the fishing season at the Ringsjöholm settlement; 1) i
