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Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass

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Background: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early detection improves future medical health. Aim: This study, which is part of the larger 5th EU-framework "genetic education'' (GenEd) study, aimed to

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Människohandel och människoexploatering beskrivs som de värsta formerna av arbetslivskriminalitet. Människohandel kan bestå i att transportera människor genom tvång, varvid syftet med handeln kan vara tvångsarbete eller att på annat sätt utnyttja arbetskraften hos en person. Människoexploatering angriper själva exploateringen. Människohandel och människoexploatering sker ofta genom att utländsk arHuman trafficking and labor exploitation are described as the most severe forms of workplace crime. Human trafficking can involve transporting individuals through coercion, with the purpose of such trafficking often being forced labor or otherwise exploiting the workforce of a person. Human exploitation targets the exploitation itself. Human trafficking and human exploitation often occur through t

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Den tekniska utvecklingen har ändrat hur människor kommunicerar med och om varandra. Den har också fört med sig nya former av övergrepp, däribland så kallade bildbaserade sexuella övergrepp. Begreppet bildbaserade sexuella övergrepp innefattar alla former av framställande och/eller spridande av privata, sexuella bilder utan samtycke från den avbildade. Exempel på sådana övergrepp är ”hämndporr”, sTechnological developments have changed the way people communicate with and about each other. It has also brought with it new forms of abuse, including so-called image-based sexual abuse. Image-based sexual abuse includes all forms of creation and / or distribution of private, sexual images without the consent of the person depicted. Examples of such abuse is “revenge porn”, stealth photography, u

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Dagens bostadsbestånd består av flerfamiljshus och drygt två miljoner småhus. Av dessa är 37 % byggda före år 1950, det vill säga 770 000 småhus. Gemensamt för husen byggda mellan åren 1880-1945 är användningen av traditionell byggteknik och materialval vid uppförandet av husen. De utgör ett värde i vårt kulturarv med en social identitet väl förankrad i sin omgivning. Dessa hus är idag i behov av

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Popular Abstract in Swedish Kemister kallas de, som förstå att utreda hwad hwarje sak består utaf, och huru man af beståndsdelarne må kunna sammansätta nya ämnen. Kunskapen härom kallas Kemi. Den största Kemisten war wår landsman Jacob Berzelius, som föddes 1779 i Wäfwersunda i Östergötland och dog i Stockholm 1848. Så skriver N. J. Berlin i sin Läsebok i Naturläran för Sweriges AllmogeThe rapid developments within the life science and biotechnology areas put up ever-new demands on more sophisticated techniques and methods for chemical and biological analysis to reach deeper insight into the events at molecular level. Miniaturisation of assays and systems on microchips is one way to increase throughput and advance through parallel analysis lines, multiplexing and integration. Th

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Popular Abstract in Swedish I alla flercelliga organismer behövs utbyte av information mellan cellerna, som bygger upp kroppen. För detta ändamål är cellerna försedda med små antenner, som kan ta emot signaler och kallas därför receptorer. Receptorer kan vara uppbyggda på olika sätt. De flesta receptorer slingrar sig sju gånger genom membranet och har ett gemensamt sätt att fortleda signaler till Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. Unfortunately, for many of these receptors the endogenous ligands, and, hence, their physiological functions, remain to be identified. These receptors are usuall

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In the late 17th century, a new style of decorations was developing in Sweden. Brutal flaming depictions of hell started covering the ceilings of the small parish churches. The trend would catch fire and over the course of the 18th century over 500 decorations were made in churches across western Sweden. This essay studies iconographic starting points for the style in the depictions the final judg

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The Canary Islands are an island chain created by volcanic activity, despite extensive studies of the region there is not a clear consensus of their process of creation, primarily there is a question concerning the origin of the magmas which has built up this chain of islands. The largest contributor to these uncertainties is the continued volcanic activity on older islands, something which does n

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Den 8 november 2024 infördes den nya förverkandeformen självständigt förverkande i 36 kap. 5 § BrB. Bestämmelsen innebär att egendom numera kan förverkas utan att åklagaren behöver styrka att något konkret brott har begåtts. För att förverka egendom genom självständigt förverkande är det tillräckligt att åklagaren gör det ”klart mera sannolikt” att egendom härrör från någon ospecificerad brottslig

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Early recognition and management of sports-related concussion (SRC), including removal from the sports activity, is essential for player safety and to prevent long-term symptoms. A graduated, stepwise rehabilitation protocol is implemented to allow the athlete to return to sports. In 2022, the 6th international consensus statement on concussion in sports was presented, which has now been adapted t

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Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15

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Perceiving and understanding human motion is a fundamental problem in computer vision, with diverse applications encompassing sports analytics, healthcare monitoring, entertainment, and intelligent interactive systems. Multi-camera systems, by capturing multiple viewpoints simultaneously, enable robust tracking and reconstruction of human poses in 3D, overcoming limitations of single-view approach

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The subfamily Stiriinae (Lepidoptera, Noctuidae) is a group of ∼160 described moth species, ∼91% of which occur in the Nearctic, with species diversity centered in the deserts, grasslands, and adjacent foothills of the mountain ranges of Mexico. We infer the first species-level phylogeny for the subfamily using 8 protein-coding genes. While some lineages are primarily leaf or flower feeders, the m

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This study explored how young Swedish adults aged 20–30 describe and understand experiences of weight-based bullying during their school years, as well as their ways of coping. A qualitative design using semi-structured interviews was employed. The sample consisted of nine young adults with a mean age of 24.7 years, including two males and seven females. All participants had lived with overweight

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Purpose: To evaluate: (i) the relationship between intraocular pressure (IOP) reduction attained with a fixed treatment protocol and the untreated IOP level; (ii) the consistency of IOP reduction over time; and (iii) whether there is a threshold pretreatment IOP level below which IOP reduction might be less effective. Results are based on 128 patients with glaucoma with field defects, who were ran

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The lack of human resources is one of the main bottlenecks to achieving the Millennium Development Goals on maternal and child health. A coherent national policy, recognized across government, needs to be in place to overcome this especially in countries severely affected by HIV/AIDS. Such a policy should cover selection of pre-service students, the qualifications of trainers and training sites, s

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Att förstå och att bli förstådd är avgörande för att människor inte ska missuppfatta varandra. I de fall det inte går att avläsa omgivningens reaktioner så som t.ex. på internet, är risken för feltolkningar eller missförstånd betydligt större. Om andra misstolkar eller missuppfattar det som har skrivits kan personen göra sig skyldig till brottet förtal. Om en kommentar får någon att känna sig illaTo understand and to be understood is crucial for people not to be misinterpreting each other. In those cases where it isn´t possible to read the ambient reaction such as for example, on the Internet, the risk of misinterpretation or misunderstanding is much greater. If others misinterpret or misunderstand what has been written, the person may be guilty of the offense of defamation. If a comment m

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Under de senaste årtiondena har Brå publicerat två rapporter som visat att invandrade personer samt personer med utländsk bakgrund är överrepresenterade bland de som registreras för brott. Intresset för denna fråga växer i takt med att invandringen till Sverige ökar. Situationen utnyttjas av nationalistiska och socialkonservativa partier och samhällsklimatet har nu hårdnat till den grad att den ökOver the past decades, The Swedish National Council for Crime Prevention has conducted two studies showing that immigrants in Sweden and people with foreign backgrounds are overrepresented amongst crime suspects. As migration to Sweden increases these studies have received more attention. Nationalistic and social conservative parties are taking advantage of the situation, why the political climate