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Mutations within the DNA mismatch repair gene, "postmeiotic segregation increased 2" (PMS2), have been associated with a predisposition to hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome). The presence of a large family of highly homologous PMS2 pseudogenes has made previous attempts to sequence PMS2 very difficult. Here, we describe a novel method that utilizes long-range PCR as
The aim of this study was to investigate from the perspective of formal carers the care given to people aged 65 and over, who are cared for in their own homes by informal care. Thirty-three district nurses (DNs) and 20 home service assistants in a municipality with 13500 inhabitants (over 65 years old), were interviewed about the location of care recipients and 398 care recipients were located. Mo
In a society increasingly characterized by cultural heterogeneity and where trust issues are becoming ever more important, new demands and dilemmas arise related to organizations’ strategic communication. This study investigates the struggles of contemporary organizations to achieve credibility and strengthen their social legitimacy as actors in Sweden’s multicultural society. The empirical case c
Nonparametric efficiency analysis has become a widely applied technique to support industrial benchmarking as well as a variety of incentive-based regulation policies. In practice such exercises are often plagued by incomplete knowledge about the correct specifications of inputs and outputs. Simar and Wilson (Commun Stat Simul Comput 30(1):159–184, 2001) and Schubert and Simar (J Prod Anal 36(1):5
Background: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early detection improves future medical health. Aim: This study, which is part of the larger 5th EU-framework "genetic education'' (GenEd) study, aimed to
The function of the efflux pump P-glycoprotein (Pgp) and ABCB1 single nucleotide polymorphisms (SNPs) should be considered as important tools to deepen knowledge of drug nephrotoxicity and disposition mechanisms. The aim of this study is to investigate the association of C3435T, G2677T, C1236T, and T129C ABCB1 SNPs with Pgp activity and exposure to different immunosuppressive drugs in renal transp
Detection of analytes in complex biological samples, such as milk and blood, normally requires sample pretreatment. These pretreatment regimes reduce assay throughput and increase testing costs. Technologies that make it possible to eliminate sample pretreatment are of great industrial interest. Here we report the development of a dual-signal flow injected analysis device which eliminates the need
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING PÅ SVENSKA Graviditetsdiabetes (GDM) definieras som ett diabetestillstånd som upptäcks under graviditet. Ofta orsakas detta tillstånd av de hormonförändringar som uppträder under graviditet vilka medför en ökad insulinresistens, dvs. ett ökat motstånd mot insulinets effekter. Diagnosen GDM utesluter dock inte diabetes av annan orsak soThe aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited
Background: Screening for bacterial colonization among risk populations could provide better estimates of the volume of the bacteria-related disease reservoir and the level of antimicrobial resistance, than do conventional laboratory reports. Methods: Two hundred and one participants at 10 Swedish nursing homes were screened for colonization with Staphylococcus aureus between January and October 2
Stable walking depends on the coordination of multiple biomechanical degrees of freedom to ensure the dynamic maintenance of whole-body equilibrium as well as continuous forward progression. We investigated adult age-related differences in whole-body coordination underlying stabilization of center of mass (CoM) position and step pattern during locomotion. Sixteen younger (20-30 years) and 16 healt
Chronic breathlessness at rest or on minimal exertion despite optimal treatment of the underlying chronic cause(s) is termed chronic refractory breathlessness. This is prevalent across the community and is an independent indicator of poor prognosis. This narrative review focuses on the palliation of chronic refractory breathlessness in people predominantly with non-cancer diagnoses. Breathlessness
Begreppet adaptation to the adverse effects of climate change är relativt nytt in internationell miljörätt. Begreppet adaptation är inte definierat i UNFCCC. Den här uppsatsen analyserar adaptation i ljuset av begreppet reparation i internationell sedvanerätt. Uppsatsen undersöker vad begreppen adaptation och reparation har gemensamt. Kan adaptation i UNFCCC ses som en möjlig utveckling eller förlThe concept of adaptation to the adverse effects of climate change is relatively recent in international environmental law. Adaptation is not defined in the UNFCCC. This paper attempts to address adaptation in the UNFCCC from the perspective of reparation under customary international law. It investigates what the concepts of adaptation and reparation have in common. Could adaptation in the UNFCCC
“Men from March, women from Venus” is a bachelor thesis where the Swedish populations consumption habits of the product groups clothes, underwear and shoes are individually examined through statistical analysis. The aim of the thesis is to examine if any differences between male and female consumption of those product groups can be determined for the first year of the financial crisis. This is det
Today, one of the most important questions around the world is that of climate change and the battle against carbon emissions. Wind power has proven to be the most successful option among renewable energy sources, and it is a crucial tool in the race to cut our carbon emissions and to safe security of supply within the EU. Until now, most of the development has occurred onshore, but offshore wind
3I/ATLAS is the third interstellar object discovered to date, following 1I/‘Oumuamua and 2I/Borisov. Its unusually high excess velocity and active cometary nature make it a key probe of the Galactic population of icy planetesimals. Understanding its origin requires its past trajectory through the Galaxy to be traced and the possible role of stellar encounters to be assessed, both as a potential or
Sammanfattning Organiserad brottslighet samt hur man bekämpar och förebygger detta relativt utbredda problem är ett prioriterat område som får allt större utrymme i svensk kriminalpolitik. Det pågår en samhällsdebatt om att införa ett kronvittnessystem i Sverige. Justitieminister Beatrice Ask förespråkar systemet i hopp om att komma till bukt med den organiserade brottsligheten. Det svenska rätAbstract Means to prevent and reduce the growth of organized crime is a prioritized area in Swedish criminal politics. There is an ongoing debate about the introduction of a crown witness system in Sweden. The minister of Justice, Beatrice Ask, supports the system in hope to reduce organized crime. The Swedish legal system and its laws are restrained to reward criminals who contribute to investi
This paper examines the impact of the Paris agreement on firms on the Swedish stock market. Additionally, the firms were also categorized into sustainable and unsustainable firms by their Environmental Pillar Score (which is part of the ESG score) in order to investigate performance differences between the two groups. On top of that, a comparison between sustainable firms with the market index OMX
Establishing a technically practical method to generate representative model catalysts for the use in characterizations and testing prior to catalyst implementation in chemical process units would allow for a more sophisticated understanding of the underlying catalytic mechanisms. As a step towards establishing such a method, generating non-agglomerated, spherical NiMo nanoparticles, with diameter
