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The calcitonin gene-related peptide (CGRP) is a 37 residue neuropeptide which causes vasodilatation, increases heart rate and inhibits bone resorption. These effects make it an interesting lead for drug discovery. We have combined current structural and biological information to model the structure of hCGRP-beta to be used as a basis for the rational design of novel analogues. Distinct regions of
Making software developers work towards a common goal may be likened to herding cats. If we further spread developers around the globe, we run increased risks of being unable to design and impose coherent software architectures on projects, potentially leading to lower quality of the resulting systems. Based on our experiences in a large, distributed research and development project, PalCom, we pr
Aim. The aim of this study is to examine associations between caregiver burden, perceived health and sense of coherence in family caregivers to persons with dementia living at home. Background. Most of the studies on family caregivers have focused on burden and morbidity. However, the caregiver's sense of coherence and perceived health have not been studied earlier in relation to caregiver burden.
This study investigated possible mediators of the identifiable victim effect (IVE), the proportion dominance effect (PDE), and the in-group effect (IGE) in helping situations. In Studies 1-3, participants rated their emotional reactions (distress and sympathy toward the victims), perceived impact of helping, perceived responsibility to help, and helping motivation toward four versions of a helping
This study estimates the causal effect of receiving additional paid vacation days on health. Using register data on the universe of central government employees in Sweden, I exploit an age-based rule stipulated in the collective agreement covering these employees. Identification is achieved by combining a regression discontinuity with a difference-in-differences design to control for time-invarian
Continues positive airway pressure (CPAP) is recommended for treatment of sleep apnoea (SA) in patients with congestive heart failure (CHF) but is not easily tolerated resulting in poor patient compliance. Mandibular advancement device (MAD) is designed to inhibit pharyngeal airway (PAW) obstruction and may be a valuable alternative. It has been proposed that MAD exerts its effect by increasing PA
Plats Hus Människa: En berättelse är ett examensarbete i arkitektur som redovisar ett byggprojekt på djupet, från den första inspirationen till ett förverkligande i full skala. När man försöker gestalta en sådan komplex process gäller det att begränsa sig genom att ha tydliga ramar. För min egen del så innebär det att jag konsekvent har utgått från en viss skola inom arkitekturen och att jag både Plats Hus Människa: En berättelse (Place House Person: A story) is a master thesis in architecture that describes a project from start to near completion in full scale. Since my personal relation to the site is strong, my point of departure is the phenomenological architecture. This architectural movement emphasizes the importance of place. The main tool of both my investigation of place and my pr
Plats Hus Människa: En berättelse (Place House Person: A story) is a master thesis in architecture that describes a project from start to near completion in full scale. Since my personal relation to the site is strong, my point of departure is the phenomenological architecture. This architectural movement emphasizes the importance of place. The main tool of both my investigation of place and my pr
This thesis aims to shed light on the impact of the so-called Pay as You Save® (PAYS ®) or on-bill programmes for energy efficiency improvements in the building sector. These programmes are based on an innovative financing model that was developed to overcome several barriers to the up-take of energy efficiency measures by households and businesses. From the consumer’s side, these barriers include
The ratio of production cross sections of the W and Z bosons with exactly one associated jet is presented as a function of jet transverse momentum threshold. The measurement has been designed to maximise cancellation of experimental and theoretical uncertainties, and is reported both within a particle-level kinematic range corresponding to the detector acceptance and as a total cross-section ratio
A multidisciplinary study of the implementation potential of a biorefinery, using forestry residues as feedstock, is performed by assessing techno-economic factors, system integration and feedstock supply. The process is based on biochemical conversion of logging residues to produce ethanol, biogas, pellets, heat and electricity. Nine models were designed in Aspen Plus based on the available feeds
The effect on intestinal macromolecular absorption capacity and immunoglobulin G (IgG) transfer of feeding sow colostrum at different intervals and in different quantities to newborn pigs was studied. An amount of 15 ml/kg body weight (BW) colostrum was fed at 3 (treatment 3-15), 6 (treatment 6-15) or 12 (treatment 12-15) h intervals, respectively, starting 0-4 h after birth for 24 h; or 30 ml/kg
A 10-bit 5-MS/s successive approximation ADC cell and a 70-MS/s parallel ADC array based on this cell, designed and fabricated in a 1.2-?m CMOS process, are presented. The ADC cell was designed to have an input bandwidth of more than 35 MHz and a sampling time of 14 nS at a clock rate of 70 MHz. The parallel ADC array consists of 14 such cells which are timed in one clock cycle skew successively i
Stroke is a significant cause of long-term disability, impairing over 10 million peoples motor function, primarily on one side of the body every year. Whilst effective rehabilitation exercises can help recover and maintain some affected motor function, stroke survivors often do not carry out enough of these. Instead relying on their `good' side to carry out tasks. However, this leads to poor recov
BackgroundThe purpose of this study was to contribute to knowledge about what is regarded as an appropriate governance model in welfare markets in healthcare, from the perspective of government. The study draws on a framework about governance in healthcare systems as a continuous process of priority setting, monitoring and accountability. It relates to various dimensions of management controls; a BackgroundThe purpose of this study was to contribute to knowledge about what is regarded as an appropriate governance model in welfare markets in healthcare, from the perspective of government. The study draws on a framework about governance in healthcare systems as a continuous process of priority setting, monitoring and accountability. It relates to various dimensions of management controls; a
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers i
This doctoral thesis presents the work the practical verification of a cooling concept involving direct air cooling of hollow windings for electric machines. The focus is on rotor windings for electrically excited synchronous machines for traction of electric vehicles. The work describes the cooling concept and compares it with the most common cooling concepts used today. The design of a experimen
Changes in farming practices over the past century have had negative influence on farmland biodiversity. Organic farming excludes most agrochemicals, such as inorganic fertilisers and synthetic pesticides, and can be an alternative to conventional farming. A recent meta-analysis indicates that there is on average 30% higher species richness on organically managed farmland compared to conventionall
BACKGROUND: Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic peptides. It is unknown if Corin loss-of-function (LOF) is causally associated with risk of coronary artery disease (CAD). METHODS: We analyzed all coding CORIN variants in an Italian case-control study of CAD. We functionally tested
