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PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq

Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise

Background: Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia. Methods: We conducted a prospective study with 403,506 partici

Background: Lung cancer patients have a risk of recurrence even after curatively intended surgery. Cell-free circulating tumor DNA (ctDNA) and circulating tumor marker measurements are easily accessible through peripheral blood and could potentially identify patients with worse prognosis. The aim of this study was to examine ctDNA in pre-operative plasma and the role of tumor markers in pre-operat

Background: Experiments have shown improved cardiovascular stability in lambs if umbilical cord clamping is postponed until positive pressure ventilation is started. Studies on intact cord resuscitation on human term infants are sparse. The purpose of this study was to evaluate differences in clinical outcomes in non-breathing infants between groups, one where resuscitation is initiated with an in

Purpose: Guidelines recommend targeting mean arterial pressure (MAP) > 65 mmHg in patients after cardiac arrest (CA). Recent trials have studied the effects of targeting a higher MAP as compared to a lower MAP after CA. We performed a systematic review and individual patient data meta-analysis to investigate the effects of higher versus lower MAP targets on patient outcome. Method: We searched the

OBJECTIVE: Radical prostatectomy reduces mortality among patients with localized prostate cancer, however up to 35% of patients will experience biochemical recurrence, often treated with salvage radiotherapy. The objective of the study was to investigate long-term effects of salvage radiotherapy. METHODS: A prospective, controlled, non-randomized trial at 14 Swedish center's including 4,003 patien

It has been shown previously that the immune system plays a role in implantation and embryo development. The objective was therefore to evaluate cytokine levels and Th1/Th2 ratio in women with recurrent implantation failure in this nested case-control study. Women with no implantation after ≥ 3 embryo transfers were included in the recurrent implantation failure group (n = 29) and were compared wi

BACKGROUND: A previous study on mechanical complications after central venous catheterisation demonstrated differences in complication rates between male and female operators. The objective of this subgroup analysis was to further investigate these differences. The hypothesis was that differences in distribution of predefined variables between operator genders could be identified.METHODS: This was

BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeut

Background: Proton radiotherapy (RT) is an attractive tool to deliver local therapy with minimal dose to uninvolved tissue, however, not suitable for all patients. The aim was to explore complications, especially severe late complications (grades 3–4), following proton RT delivered to a complete Swedish cohort of paediatric patients aged <18 years treated 2008–2019. Material and Methods: Data was

BACKGROUND: Medium vessel occlusions (MeVO) can be either isolated events (primary), or secondary to thrombus migration from a large vessel occlusion to a medium-sized vessel. Outcomes following endovascular thrombectomy (EVT) in the middle cerebral artery (MCA) may differ between primary and secondary MeVOs. This study aimed to assess the association between primary/secondary MeVOs and clinical o

Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors Christian Berrios,a,b Joonil Jung,c Blake Primi,d,e Michael Wang,f Chandrasekhar Pedamallu,a,c Fujiko Duke,a,c Christina Marcelus,a Jingwei Cheng,a,g Robert L. Garcea,d,e Matthew Meyerson,a,c,h James A. DeCaprio,a,b,g the TEDDY Study Group Department of Medical Oncology, Dana-Farber Cancer Institute, Boston,

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/38%2006032016_679_38_Berrios_JVirology_2014.pdf - 2026-04-24

Negative symptoms (avolition, anhedonia, asociality, blunted affect, and alogia) are among the most disabling features of schizophrenia spectrum disorders. In the absence of treatment consensus guidelines, this PRISMA-compliant meta-analysis (PROSPERO: CRD42024613967) evaluated efficacy and clinical significance of interventions targeting this dimension. Web of Science/PsycInfo databases were sear

RESEARCH IN SERVICE STUDIES LUND UNIVERSITY, Campus Helsingborg Working paper No 4, May 2011 The Department of Service Management The Business Model of Swedish Municipal Waste Management Companies Hervé Corvellec, Torleif Bramryd & Johan Hultman The Business Model of Swedish Municipal Waste Management Companies Hervé Corvellec*, Torleif Bramryd and Johan Hultman Department of Service Management Lu

https://www.ses.lu.se/sites/ses.lu.se/files/wp_4_2011.pdf - 2026-04-24

Master’s Dissertation Structural Mechanics Report TV SM -5223 A X EL K JELLM A N STR U C TU R A L R O B U STN ESS FE m eth o d o lo g y fo r an alysin g altern ate lo ad p ath s in b u ild in g s AXEL KJELLMAN STRUCTURAL ROBUSTNESS FE methodology for analysing alternate load paths in buildings 5223HO.indd 15223HO.indd 1 2017-07-04 15:35:022017-07-04 15:35:02 DEPARTMENT OF CONSTRUCTION SCIENCES DIV

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5223.pdf - 2026-04-23

Master’s Dissertation Structural Mechanics ANDREAS OTTOSSON IMPLEMENTATION OF CALFEM FOR PYTHON Detta är en tom sida! Copyright © 2010 by Structural Mechanics, LTH, Sweden. Printed by Wallin & Dalholm Digital AB, Lund, Sweden, August, 2010 (Pl). For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sweden. Homepage: http://www.byggmek.lth.se Str

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5167.pdf - 2026-04-23

Here you will find research project with awarded grants, stipends and other types of monetary funding, that has been approved and granted to researchers at LUSEM by major external funders. Have you been granted a research grant? Would you like the information to be here?The information on this page is a feed of projects from the Research Portal (LUCRIS). For guidelines and assistance please refere

https://www.lusem.lu.se/internal/research/funding-grants-and-scholarships/granted-funds-and-stipends-lusem-researchers - 2026-04-23

ON FIRST AND SECOND CYCLE STUDIES Programme evaluations are an important part of the quality assurance process at LUSEM and serve as a basis for continuous programme development. It also provides the students with an opportunity to exercise their student influence. All educational programmes must undergo a programme evaluation. It is the responsibility of the programme director to conduct a progra

https://www.lusem.lu.se/internal/education/programme-evaluations - 2026-04-23