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AIM OF THE STUDY: To produce an empirical estimate of the nature and magnitude of the error produced by incorrect timing quality of life (QoL) measurements in patients receiving chemotherapy.DESIGN: In a multicentre trial, 283 patients were randomized to receive either docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). The QoL was assessed at baseline and before each treatment using
The design and implementation of a 1024-point pipeline FFT processor is presented. The architecture is based on a new form of FFT, the radix-22 algorithm. By exploiting the spatial regularity of the new algorithm, minimal requirement for both dominant components in VLSI implementation has been achieved: only 4 complex multipliers and 1024 complex-word data memory for the pipelined 1K FFT processor
This paper presents an injection-locked frequency tripler for 28-GHz direct-conversion transceivers, which takes a differential input and outputs a quadrature signal. A feedback system is added to ensure that lock occurs and to keep the quadrature error below 1° across operating frequencies and process corners. Simulations show that the tripler can cover the entire 24-30 GHz band across all corner
The main function of the reactor containment, i.e. to ensure tightness at a major internal accident, depends directly on the prestressing system. To secure that the prestress level is sufficient, the tendon force has been measured during the whole time of operation. The general results from these measurements show that the loss of prestress 30 years after tensioning is between 5 and 10%. This is m
We have used DNA microarrays to survey rates of mRNA decay on a genomic scale in early stationary-phase cultures of Bacillus subtilis. The decay rates for mRNAs corresponding to about 1500 genes could be estimated. About 80% of these mRNAs had a half-life of less than 7 min. More than 30 mRNAs, including both mono- and polycistronic transcripts, were found to be extremely stable, i.e. to have a ha
Purpose: Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Using real-world data, we evaluated the risk of digitalis intoxication in concomitant users of dronedarone and digoxin compared digoxin-alone users. Methods: We used the Clinformatics DataMart, a US claims database, to identify adult patients with atrial fibrillation (AF) or atrial flutter (AFL) who conco
AIMS: Although the epidemiological association between Type 2 diabetes and congestive heart failure (CHF) as well as cardiovascular disease (CVD) is well established, associations between diabetes-related single-nucleotide polymorphisms (SNPs), CHF, and CVD have been surprisingly inconclusive. Our aim is to examine if 43 diabetes-related SNPs were associated with prevalent diastolic dysfunction as
The human L3MBTL gene is located in 20q12, a region that is commonly deleted in myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs
A single vaginal washing with 2 g/l of chlorhexidine was performed before rupture of the membranes in 19 parturients who were urogenital carriers of group B streptococci (GBS). Two (11%) of the infants became colonized immediately after birth, in contrast to 16 of 41 (39%) infants to controls (P = 0.02). A significant reduction of GBS colonization of the ear (P = 0.02) and umbilicus (P = 0.01) was
We report a new design of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. Acoustic trapping enables nanoparticle and exosome enrichment without the need for ultracentrifugation. The commercial acoustic trapping technology, AcouTrap (AcouSort AB), typically operates at flow rates < 50 μl/min which limits processing of larger
We study the process gg → bb̄H+H- at large tanβ, where it represents the dominant production mode of charged Higgs boson pairs in a Type II 2-Higgs doublet model, including the minimal supersymmetric standard model. The ability to select this signal would in principle enable the measurements of some triple-Higgs couplings, which in turn would help understanding the structure of the extended Higgs
Speed control is the most important aspect of promoting road safety world-wide. The question is how are speeds developing? The European Transport Safety Council concludes: There is little progress on reducing speeds in Europe. Similar conclusions can be drawn from the US and Australia. Attitude surveys show that people’s answers are not very consistent and represent statements without any strong b
Studien har som syfte att undersöka huruvida flygolyckor påverkar flygplanstillverkares aktiepriser. Tidsperioden som undersöks är mellan år 2000 och 2018 och begränsas till olyckor där 30 personer eller fler miste livet. Metoden som ligger till grund för arbetet är en händelsestudie som tillsammans med statistiska test undersöker effekten av flygolyckor. Historiska data i form av faktiska aktiekuThe purpose of this study is to investigate whether aircraft accidents affect the stock prices of aircraft manufacturers. The time period examined is between 2000 and 2018 and is limited to accidents where 30 people or more lost their lives. The method that underlies the work is an event study that, together with statistical tests, investigates the effect of airplane crashes. Historical data in th
Background: The goal of clinical computed tomography (CT) is to produce images of diagnostic quality using the lowest possible radiation exposure. Degradation of image quality, with increased image noise and reduced spatial resolution, is a major limitation for radiation dose reduction in CT. This can be counteracted with new post-processing image filters and iterative reconstruction (IR) algorith
The purpose of this essay was to analyze the collapse of democracy in the Weimar Republic. This was done by analyzing some of the most turbulent crises in its history like the communists attempt to take power in 1919, the kapp-putsch of 1920, hyperinflation 1923 and the economic depression 1929-1933. The method that I used in this essay is called methodological individualism. It was an analytical
