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BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina

PurposeThere is a growing demand for a concurrent development of product and packaging in order to better take into account the supply chain needs. Different tasks are required to integrate packaging and product development: 1) At the strategic level, it is necessary to define or refine an integrated development policy; 2) For each new development project, an adaptation of this policy must be unde

OBJECTIVE: To explore physicians' thoughts and considerations of participation in medical decision making by hospitalised elderly patients.DESIGN: A qualitative study using focus group interviews with physicians interpreted with grounded theory and completed with a questionnaire.SETTING AND PARTICIPANTS: The setting was three different hospitals in two counties in Sweden. Five focus groups were co

Background: Differences in cystatin C and creatinine-based estimated glomerular filtration rate (EGFR) can lead to clinical uncertainty. Existing EGFR equations perform poorly in a subset of individuals. This study aims to describe the prevalence of differences between cystatin C-based (EGFRcys) and creatinine-based (EGFRcreat) EGFR in older adults and to explore which subsets of individuals may b

Objective. To analyze the experience of a single centre using stent-grafts for treatment of complicated acute aortic type B-dissections (EVR-ABD). Design. Retrospective analysis of prospectively collected data from patients undergoing EVR-ABD between January 1997 and December 2004. Methods. EVR-ABD was performed in 31 patients (20 males, median age 74. years (IQR: 64-79)). Indications for treatmen

Objective: To examine the effect of photodynamic therapy (PDT) on experimental liver tumours in rats. Design: An experimental liver tumour model was used. Each of a group of Fats had two tumours simultaneously inoculated into its liver. The tumour located in the left hepatic robe was used for PDT, and the other one, in the median lobe, as a control. The haem precursor delta-amino laevulinic acid (

Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with

OBJECTIVE: : To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay. STUDY DESIGN: : Prospective, consecutive case series compared with historic controls. SETTING: : Secondary referral academic hospital. PATIENTS: : Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 d

PURPOSE: The development of tumor-specific markers to select targeted therapies and to assess clinical outcome remains a significant area of unmet need. We evaluated the association of baseline circulating tumor cell (CTC) number with clinical characteristics and survival in patients with castrate metastatic disease considered for different hormonal and cytotoxic therapies. EXPERIMENTAL DESIGN: CT

OBJECTIVE. Newborns routinely receive vitamin K to prevent vitamin K deficiency bleeding. The efficacy of oral vitamin K administration may be compromised in infants with unrecognized cholestasis. We aimed to compare the risk of vitamin K deficiency bleeding under different propylactic regimens in infants with biliary atresia. PATIENTS AND METHODS. From Dutch and Danish national biliary atresia re

Advances in mobile and wireless technology have expanded the scope of electrodermal research. Since traditional electrodermal measurement sites are not always suitable for laboratory research and are rarely appropriate for ambulatory measurements, there is a need to explore and contrast alternate measurement locations. We evaluated bilateral electrodermal activity (EDA) from five measurement sites

Woodlands are a core component of urban green infrastructure in terms of both ecosystem service provision and areal cover, with particular relevance and potential for engaging citizens in co-management approaches. Despite widespread agreement on the importance of user participation, there is still a lack of comprehensive knowledge on the underlying drivers. Extending existing knowledge is importan

Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proport

In a learning situation, feedback is of great importance in order to help a student to correct a possible misconception. However, previous research shows that many students tend to avoid feedback regarding failures, including critical constructive feedback (CCF) that is intended to support and guide them. This is especially true for lower-achieving students, who might perceive feedback as an ego-t

Objective: To investigate the statistical power of plasma, imaging, and cognition biomarkers as Alzheimer’s disease (AD) clinical trial outcome measures. Methods: Plasma neurofilament light, structural magnetic resonance imaging, and cognition were measured longitudinally in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in control (amyloid PET or CSF Aβ42 negative [Aβ-] with Clinical Deme

Prostate-specific antigen (PSA) and human prostatic glandular kallikrein (hK2) have 79% identity with the primary structure. When we used recombinant hK2 protein, only 7 of 23 monoclonal anti-PSA IgGs (monoclonal antibodies, MAbs) cross-reacted with hK2, which enabled us to design a novel immunofluorometric MAb-MAb assay for the specific detection of hK2. In the first incubation, an excess of MAb

Popular Abstract in Swedish Hur kan nattaktiva insekter se i mörker med fel sorts ögon? Majoriteten av alla dagaktiva insekter har en sorts facettöga som kallas appositionsöga. Appositionsögon är anpassade till ett liv med god tillgång på ljus ? nattaktiva djur har därför i princip alltid andra sorters ögon (superpositionsögon). Anledningen till att appositionsögon fungerar bäst på dagen är att dDue to our own preference for bright light, we tend to forget that many insects are active in very dim light. The reasons for nocturnal activity are most easily seen in tropical areas of the world, where animals face severe competition for food and nocturnal insects are able to forage in a climate of reduced competition and predation. Generally nocturnal insects possess superposition compound eye

Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char

Various studies have highlighted older persons' problems in potentially failing to keep pace with developments in information technology and the latest technologies that prevent physical and social loss. In contrast to such studies that treat users as static and technology as changing, it's important to understand the use of technology can change over time. For example, older persons have used tec