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Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. Among them, the Aβ40 variant is predominantly found in the cerebrospinal fluid while the Aβ42 variant appears as fibrillar aggregates in the brain of AD patients. In vitro studies confi
Climate change impacts are being felt across sectors in all regions of the world, and adaptation projects are being implemented to reduce climate risks and existing vulnerabilities. Climate adaptation actions also have significant synergies and tradeoffs with the Sustainable Development Goals (SDGs), including SDG 5 on gender equality. Questions are increasingly being raised about the gendered and
Since the early 1990s, many variants of the tPSA assay have been introduced to increase the sensitivity of screening programs (cancer detection) while maintaining specificity (elimination of unnecessary biopsies). Again, these guidelines recommend ways that individuals and their physicians can use these new techniques rationally for early detection of prostate cancer. These guidelines are not desi
Participation in clinical work is important for medical students’ professional development. However, students often report that they experience a passive observer role, and further research on contextual factors that influence student participation is needed. The theory of practice architectures contributes a new perspective to this challenge by elucidating how cultural-discursive, material-econom
Transcending initial efforts to make cities “climate smart” by focusing on the potential of new technologies and infrastructural interventions, various actors are increasingly interested in deploying nature to help achieve urban resilience. In this context, rather than taking resilience as a given property of particular systems or entities, it is important to examine why, how, with what implicatio
BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movemen
BackgroundChildren and youth who experience divorce are found to have increased risk of emotional and behavioural adjustment problems. Different prevention programmes have been developed to help and support children. Previous studies have focused on the child or the group leader's experience with divorce groups, but studies describing parent's experience are missing. The aim of this study was to e
BackgroundIn primary health care people with mental health needs are often overlooked or masked with physical complaints. It has been suggested that public health nurses lack sufficient knowledge when encountering people with mental health problems. Low levels of mental health literacy among professionals are associated with negative patient outcome. There is a need to understand public health nur
Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using
Contralateral anterior cruciate ligament (ACL) injuries are together with the risk of developing osteoarthritis of the knee and the risk of re-rupture/graft failure important aspects to consider after an ACL injury. The aim of this review was to perform a critical analysis of the literature on the risk factors associated with a contralateral ACL injury. A better understanding of these risk factors
BACKGROUND: father's sense of security in the early postnatal period is important for the whole family. An instrument, which measures Parents' Postnatal Sense of Security (the PPSS instrument), is under development. OBJECTIVE: to explore and describe factors, which influence fathers' sense of security during the first postnatal week. METHODS: an explorative design with a qualitative approach was u
Background Virtual reality (VR) technology is increasingly being explored as a tool to help reduce aggressive behavior in forensic psychiatric settings. This study aimed to explore the experiences of therapists and ward staff participating in a pilot study of a VR-assisted aggression treatment within a Swedish maximum-security forensic psychiatric clinic.Methods A qualitative, descriptive, and exp
Purpose– This paper employs theories of experiential learning to examine why some entrepreneurs have developed a more positive attitude towards failures compared to others.Design/methodology/approach– The paper conducts statistical analysis on a sample of 231 Swedish entrepreneurs that have started new independent firms in 2004.Findings– The empirical findings support the guiding proposition that
Besides thriving on altered glucose metabolism, cancer cells undergo glutaminolysis to meet their energy demands. As the first enzyme in catalyzing glutaminolysis, human kidney-type glutaminase isoform (KGA) is becoming an attractive target for small molecules such as BPTES [bis-2-(5 phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide], although the regulatory mechanism of KGA remains unknown.
Playing outdoors in nature with peers has been attributed most importance for children's healthy development but is increasingly marginalized because of the attractiveness of screen-based play. Careful merging of digital technology into outdoor play environments rich on nature elements could potentially help bridge digital play with more traditional play activities outdoors. A systematic compariso
The impact of interface defect states on the recombination and transport properties of charges in asymmetric modulation-doped InGaAs/GaAs quantum wells(QWs) is investigated. Three sets of high-mobility InGaAs QW structures are systematically designed and grown by the metal-organic vapor phase epitaxy technique to probe the effect of carrier localization on the electro-optical processes. In these s
Purpose: The study explores how organizational space and situational strength influence bystanders’ intentions to intervene in workplace bullying within the healthcare sector. Design/methodology/approach: The research employs vignette-based interviews with 24 healthcare professionals from various medical fields in Sweden. The vignettes depict different bullying scenarios occurring in various spati
Under lång tid var den rådande uppfattningen att ett maskeringsförbud skulle strida mot regeringsformen och Europakonventionen om skydd för de mänskliga rättigheterna. I samband med ”Göteborgskravallerna” 2001 kritiserades Polismyndighetens bristande förmåga att upprätthålla ordning och säkerhet och denna uppfattning förändrades. Den 1 januari 2006 trädde lag (2005:900) om maskeringsförbud i vissaFor a long time the prevailing opinion in Sweden was that a masking prohibition would be a too far-reaching restriction on constitutional human rights, and thus contrary to both the constitution and the European Convention on Human Rights. In the wake of the “Gothenburg riots” in 2001, massive criticism was directed at the Police Authority for not maintaining order and security, which helped chang
