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Background: Molecular signatures in prostate cancer (PCa) tissue can provide useful prognostic information to improve the understanding of a patient's risk of harbouring aggressive disease. Objective: To develop and validate a gene signature that adds independent prognostic information to clinical parameters for better treatment decisions and patient management. Design, setting, and participants:

OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We conducted summary-level univariable and multivariable Mendelian randomization (MR) analyses in 921,908 participants to investigate the effect of lowering

It has been argued that older people living with dementia often experience stigma. Several media interventions have been designed to raise public awareness about dementia, as well as to de-stigmatise the condition and people living with it; however, few studies have investigated how media interventions may serve to reduce stigma. The present study focused on a Chinese reality show, Forget Me Not C

IMPORTANCE: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.OBJECTIVE: To investigate the diagnostic performance

Purpose: The customer experience (CX), as revealed in the literature-based debate, has been variously viewed as either a driver or an outcome of customer-perceived value (CPV). However, the association of CPV, CX and word-of-mouth (WoM) behavior remains nebulous to date, thereby generating an important research gap. In response and to bridge this gap, this study aims to explore CX’s role in the CP

PurposeThe paper aims to offer an approach that allows an analysis and construction of a typology of virtual city brand co-creation practices.Design/methodology/approachThe approach is illustrated by using data collected in regard to the branding of Stockholm; it is based on visual representations expressing the process in which brand co-creation unfolds in a network of different affective modalit

Cementproduktion står idag för en ansenlig andel av världens koldioxidutsläpp, vilket driver utvecklingen av bindemedel med lägre koldioxidutsläpp. För utsläppen i ett längre perspektiv är dock de nya bindemedlens beständighet absolut avgörande. De flesta nedbrytningsmekanismer är direkt relaterade till både fukt- och jontransport. Dessa processer har undersökts i många studier, men huvudsakligen Cement production is responsible for a significant portion of manmade CO2 emissions. This motivates the development of cementitious binders with a lower carbon footprint. Considering the emissions in a longer perspective, the durability of concrete structures is absolutely essential. Most degradation of concrete structures is closely related to both moisture transport and ion transport. Many studi

Context: Type 2 diabetes mellitus (T2DM) is accompanied by an increased risk for coronary artery disease (CAD), but the overlapping metabolic disturbances preceding both diseases are insufficiently described. Objective:Wehypothesized that alterations in metabolism occur years before clinical manifestation of T2DM and CAD and that these alterations are reflected in the plasma metabolome. We thus ai

Electrical machines, chokes and induction heaters are found in most homes,offices and factories all over the world. They are used to create movement, filtrate the power or to generate heat. A typical unit consist of a coil and a flux conductor material. Some of the materials have been established for over 100 years, while others are only a couple of decades old.A new flux conductor material has be

Purpose: The aim of this paper was to describe how people living with a neurological disability such as multiple sclerosis, Parkinson’s disease and stroke reason regarding using apps to facilitate self-management in everyday life.Material and methods: A qualitative research approach with a focus group methodology was used. The sample comprised 16 participants, 11 men and 5 women, with an average a

Purpose: From the background of the dramatic increase of urban tourism, framed by the concept of overtourism, the purpose of this paper is to analyze and discuss current dynamic processes of urban tourism growth, as presented in the scientific literature. With the help of a literature review, this paper aims to discuss current definitions and conceptualizations of overtourism and discuss the drivi

This paper presents a method to grasp objects that cannot be picked directly from a table, using a soft, underactuated hand. These grasps are achieved by dragging the object to the edge of a table, and grasping it from the protruding part, performing so-called slide-to-edge grasps. This type of approach, which uses the environment to facilitate the grasp, is named Environmental Constraint Exploita

Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to estimate the relative importance of genetic and environmental factors in the etiology of different caries outcomes using a twin-based design. Analysi

A central issue in the study of primate communication is the extent to which individuals adjust their behaviour to the attention and signals of others, and manipulate others’ attention to communicate about external events. I investigated whether 13 chimpanzees (Pan troglodytes spp.), 11 bonobos (Pan paniscus), and 7 orangutans (Pongo pygmaeus pygmaeus) followed conspecific attention and led others

This is a master thesis about how to be able to clean an open device during assembly for the company of McNeil AB. McNeil AB is a company in Helsingborg, Sweden, producing the Nicorette brand, which is a nicotine based product line which helps people stop smoking. McNeil AB's problem was that they had some contamination in their mouth spray product and thus a solution for the cleaning of a via

Purpose: The purpose of this research was to understand how consumers morally judge advocacy advertising in contemporary consumer culture. The phenomenon was explored with the help of three case studies, namely Nike, Gillette, and Pepsi, all being brands who have taken a political stance in their advertisement campaigns. Theoretical Perspective: To analyse the empirical material, we first delved

The Department of Automatic Control at Lund University annually gives a project course in Automatic Control (FRTN40). The course is given at the advanced level (7.5 ECTS credits), and the students work in small teams to achieve a common goal. The projects typically involve a real-world estimation or control problem with relevance to industrial or other applications. In this course, the students ge

Purpose: The purpose and aim with this research was to understand how brands successfully can co-opt a social movement; specifically feminism, as part of their brand building-strategies. The phenomenon was explored by comparing one successful case, Libresse’s ‘RedFit’ campaign, with a relatively the less successful case; that is, H&M’s ‘Ladylike’ campaign. Methodology: This study takes a rela

Given the rise of new startups and the challenges amplified by events like the Covid-19, it is critical to address the notion of the Entrepreneurial Ecosystem which, in turn, facilitates the development of new ventures. One of the actors within this ecosystem is startup accelerators, which provide networking opportunities, financial and mentoring assistance to new ventures. Previous research on ac