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IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G.
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-
Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha
Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel
New treatments in hemophilia: insights for the clinician.
Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in
Analysis of the molecular interplay between Streptococcus pyogenes and its human host
The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl
Two major classes in the M protein family in group A streptococci
The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh
Investigation on the effects of fly ash particles on the thermal radiation in biomass fired boilers
Ash is produced in combustion of biomass. Sonic part of this matter is called fly ash and is carried by the flow and causes not only air pollution and erosion, but also call affect the thermal radiation. The effects of fly ash particles oil the thermal radiation are considered ill this investigation. By analyzing sampled data in all electrostatic filter, a realistic particle size distribution is f
BspK, a serine protease from the predatory bacterium Bdellovibrio bacteriovorus with utility for analysis of therapeutic antibodies
The development of therapeutic and diagnostic antibodies is a rapidly growing field of research, being the fastest expanding group of products on the pharmaceutical market, and appropriate quality controls are crucial for their application. We have identified and characterized the serine protease termed BspK (Bdellovibrio serine protease K) from Bdellovibrio bacteriovorus and here show its activit
Nanoparticle-Assisted Pool Boiling Heat Transfer on Micro-Pin-Fin Surfaces
The Effect of Coupling Memory and Block Length on Spatially Coupled Serially Concatenated Codes
Prevalence of factor V gene mutation amongst myocardial infarction patients and healthy controls is higher in Sweden than in other countries
OBJECTIVE: Haemostatic imbalance may be an aetiological factor in the development of acute coronary syndromes. Inherited resistance to activated protein C (APC) is a common disorder associated with hypercoagulability and lifelong risk of venous thrombosis. APC resistance is due to a single mutation in the gene coding for coagulation factor V (FV:Q506). To test the importance of the FV:Q506 mutatio
Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis
A bispecific IgG format containing four independent antigen binding sites
Who Will Shift? Learning Household Flexibility from Behavioral Patterns in Electricity Usage
This thesis develops an application-oriented framework to identify and predict residential demand-side flexibility from the temporal structure of electricity use, rather than energy totals. We construct structure-based, price-aligned labels that track shifts between peak and off-peak hours, and train three complementary models: a next-day behavioral classifier (M1) for short-horizon operations, a
SciLifeLab DDD at the Department of Immunotechnology will present its processes and academic collabo
SciLifeLab DDD at the Department of Immunotechnology will present its processes and academic collaborations Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned of
Varför slipper en del diabetiker komplikationerna? – Vetenskap och Hälsa
Varför slipper en del diabetiker komplikationerna? – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Varför slipper en del diabetiker komplikationerna? 2011-01-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Dreamstime Nu vänder forskarna på fråga
https://www.vetenskaphalsa.se/varfor-slipper-en-del-diabetiker-komplikationerna/ - 2026-05-29
Research
High-precision observational astrophysics: solar and stellar spectroscopy, stellar surface structure, radial velocities and wavelength shifts, methods in searches for exoplanets, intensity interferometry, quantum optics, and other. Highest-precision stellar spectroscopySpectroscopy reveals the structure of stellar surfaces and enables to determine their physical properties. ‘Ab-initio’ hydrodynam
https://www.astro.lu.se/~dainis/research - 2026-05-29
STN Green
Varför slipper en del diabetiker komplikationerna? – Vetenskap och Hälsa
Varför slipper en del diabetiker komplikationerna? – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Varför slipper en del diabetiker komplikationerna? 2011-01-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Foto: Dreamstime Nu vänder forskarna på fråga
https://www.vetenskaphalsa.se/varfor-slipper-en-del-diabetiker-komplikationerna/comment-page-1/ - 2026-05-29
