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X-linked retinitis pigmentosa (XLRP) is a severe form of inherited progressive retinal degeneration. The RP3 (retinitis pigmentosa type 3) locus at Xp21.1 is believed to account for the disease in the majority of XLRP families. Linkage analysis and identification of patients with chromosomal deletion have refined the location of the RP3 locus and recently have led to the cloning of the RPGR (retin

Background: Arginine vasopressin has complex actions in critically ill patients, involving vasoregulatory status, plasma volume, and cortisol levels. Copeptin, a surrogate marker for arginine vasopressin, has shown promising prognostic features in small observational studies and is used clinically for early rule out of acute coronary syndrome. The objective of this study was to explore the associa

Patient organisations contribute to many areas of pharmaceutical policy. In developing their organisational capacity, many turn to financial support from pharmaceutical companies, which may create conflicts of interests. However, the transparency of the industry’s self-regulatory approach to the disclosure of payments to patient organisations has evaded scrutiny. Using company reports disclosing p

A search is performed for a heavy particle decaying into different flavour dilepton pairs (eμ, eτ or μτ), using 3.2 fb- 1of proton–proton collision data at s=13 TeV collected in 2015 by the ATLAS detector at the Large Hadron Collider. No excess over the Standard Model prediction is observed. Limits at the 95 % credibility level are set on the mass of a Z′boson with lepton-flavour-violating couplin

Background Improved availability of mobile phones in low- and middle-income countries (LMICs) offer an opportunity to improve delivery of Community Case Management (CCM). Despite enthusiasm for introducing mHealth into healthcare across LMICs, end-user attitudes towards mHealth solutions for CCM are limited. We aimed to explore Health Surveillance Assistants’ (HSAs) perceptions of the Supporting L

Purpose: Few studies have reported non-acute long-term morbidity rates in children with intestinal malrotation. The aim of this study was to investigate the rate of constipation in children undergoing Ladd's procedure for isolated intestinal malrotation. Methods: This retrospective study included children aged <15 years who underwent Ladd's procedure for intestinal malrotation between 2001 and 201

Primary HPV screening for cervical cancer by HPV mRNA testing (Aptima)was implemented in January 2017, for women ≥30 through 70 years, in the Region of Skåne, Sweden. HPV positive samples underwent cytology assessment, and women with any degree of abnormal cytology were referred for colposcopy. The aim was to audit the primary HPV screening program, by comparing the cytology results to those of co

We introduce a new database of historical Genuine Savings (GS), an indicator of sustainable development promoted by the World Bank and widely used in contemporary economic research. GS derives from the theoretical work on wealth accounting, and addresses shortcomings in conventional metrics of economic development by incorporating broader measures of saving and investment, including human capital

Under 2013 utgjorde värdet av medlemsstaternas offentliga upphandling ungefär 18 procent av deras BNP, vilket gör det till ett kraftfullt verktyg att använda för att främja vissa samhällsmål. Traditionellt sett så har offentlig upphandling använts i ett protektionistiskt syfte för att skydda nationell industri från utländsk konkurrens, vilket är en bidragande faktor till att EU har valt att lagstIn 2013, approximately 18 % of member states GDP was spent on public procurement, making it a powerful tool for governments to use to further certain objectives. Traditionally, public procurement has been used for protectionist purposes to safeguard national industry from foreign competition, which is why the EU has chosen to regulate this area of law to ensure the proper functioning of the inter

Buildings from the so called Million programme has a high use of energy and in addition, there are many such houses. The need for them to be retrofitted is big. The City of Helsingborg has set a climate goal which states that the city in 2035 should be neutral in energy use which put a lot of pressure on the real estate owners in the city. All new buildings has to be energy efficient and older bui

Inom läkemedelssektorn, originalföretagen som investerar stora summor pengar i forskning och utveckling av nya läkemedel vanligtvis söker patent för flera skyddsområden. De försöker utnyttja det monopol ett patent ger för att skydda sina egna originalläkemedel mot generiska läkemedels marknadsinträde och utebliven vinst som det för med sig. Generiska företag för att kunna lansera sina generiska prIn the pharmaceutical sector, originator companies that invest large sum of money in R&D of new medicines usually file patent applications for several areas of protection. They try to take advantage of a monopoly that a patent grants to protect their medicines against generic entry on the market and consequently the loss of profits. Generic companies in order to be able to launch their generic

A spoon full of insulin helps blood sugar go down Glucose is the primary source of fuel our bodies extract from carbohydrates to power our cells. Once glucose is released into the blood stream, pancreas reacts by releasing insulin into the blood stream. Insulin is a hormone which allows cells to uptake glucose after a meal. However, when insulin is not produced by the pancreas, or the cells don’

Nollbeskattningen av gemenskapsinterna förvärv i kombination med uppskjuten betalning av moms har möjliggjort karusellbedrägeri med moms på den EU-interna marknaden. Följaktligen har medlemsstaterna drabbas av utebliven moms som inte redovisas av ”missing traders”, samtidigt som den oskyldige affärspartnern till en ”missing trader” behåller sin rätt att återfå moms, vilket skapar en förlust för stThe zero-rating of intra-Community acquisitions in combination with the deferred payment of VAT has made it possible to employ carousel fraud with VAT on the internal EU market. Not only are the tax authorities in the different Member States losing out on VAT that is not accounted for by missing traders, but the innocent parties in business with the missing traders retain a right to refund VAT, le

Vid utformandet av en konstitution ställs alltid frågan om vilket förhållande som bör råda mellan politik och juridik. Det är upp till varje rättssystem att reglera vilket inflytande domstolen ska ha på utformningen av lagstiftningen. När det kommer till lagstiftning kan förhållandet mellan judiciell aktivism från domstolens sida och demokrati beskrivas som en dikotomi där två vitt skilda metoder When drafting a Constitution, the relationship between politics and law must always be determined. It is up to each legal system to regulate what influence the court should have on the formulation of legislation. When it comes to legislation, the relationship between judicial activism and democracy, can be described as a dichotomy in which two widely different methods stand for different ideals. T

Syftet med denna uppsats är att undersöka tillämpningen av oaktsam våldtäkt, 6 kap 1a § BrB, utifrån ett rättssäkerhetsperspektiv. Först genom att undersöka det nya brottets uppbyggnad och struktur utifrån förarbeten och lagtext, därefter genom att se hur brottets tillämpats i praktiken. Det nya brottet oaktsam våldtäkt instiftades i svensk lag den 1 juli 2018. Första gången brottet diskuteradesThe purpose of this thesis is to examine negligent rape in chapter 6 section 1 of the Swedish Criminal Code (brottsbalken, SFS 1962:700) from a legal security perspective. First by examining how the legislator described the requirement in the legislative history and in the text of the law, thereafter by examine how the law has been applied in practice. The new crime of negligent rape was institut

The purpose of the study has been to investigate young adults’ experiences of being unemployed in more than six months, which in a national context is being accounted as long- term unemployment. To answer the purpose of the study two questions have been asked: ’In what way are the young adults affected by not having a job?’ and ’What feeling are related to the young adult’s situation as unemployed

Engagemang på sociala medier inom politisk kommunikation är ett aktuellt forskningsområde för strategisk kommunikation. I det digitala samhället finns det starka incitament för partier att skapa ett högt engagemang på sociala medier för att nå ut med sina politiska budskap. Syftet med den här studien är att undersöka hur engagemang som beroende variabel kan förklaras med kommunikationsstrategier, Engagement on social media in political communication is a highly relevant area for strategic communication research. There are clear incentives for political parties to create high levels of engagement in their social media channels, in order to reach out with their political messages in today’s digital society. The purpose of this study is to examine to which degree the dependent variable engage

An increasing number of organisations are purchasing culture measurement solutions without reflecting on how ‘measurement’ mirrors organisational reality. This is because the dominant perspective of culture measurement caters to managers and claims to deliver absolute readings. Concurrently, constructivist scholars have often neglected the potential for culture surveys to act as interpretative str

En spallationskälla börjar generellt med en kraftig linjär protonaccelerator, som skickar en högenergisk protonstråle rakt in i ett neutrontätt mål. Strålens högenergiska protoner frigör neutroner från de neutronrika atomerna i målet via intra-nukleära interaktioner, vilket är själva spalleringsprocessen. Desto högre effekt den levererade protonstrålen har, desto fler neutroner frigörs. Därmed reThe European Spallation Source is currently under construction in Lund, Sweden. Consisting of a linear accelerator delivering an unprecedented 5 MW proton beam to the spallation source, i.e. a rotating Tungsten disk, it will deliver high-flux neutron beams to multiple beamlines at which scientific experiments will be conducted in many scientific disciplines. To simulate the proton beam and for cr