Sökresultat

Hjärntumör inklusive glioblastom.Glioblastom är den vanligaste sortens hjärntumör bland vuxna och samtidigt den mest elakartade. Glioblastom drabbar cirka 550 personer årligen i Sverige. När tumören upptäcks är behandlingen först operation för exakt diagnos och med syfte att avlägsna så mycket som det går av tumören, utan att orsaka skada för patienten, annars görs en diagnostisk biopsi. StandardAbstractBackground: Glioblastoma is the most common malignant brain tumor. Operation with maximal resection, if feasible, otherwise biopsy followed by radiotherapy and chemotherapy with temozolomide is standard therapy. The prognosis remains poor, with median overall survival being 15 months despite therapy. Improved monitoring and treatment response assessment will be important when seeking to im

Popular Abstract in Swedish I denna avhandling presenteras fyra nya metoder för att automatiskt mäta hjärtats förmåga att pumpa ut blod i kroppen, mäta storleken på en hjärtinfarkt samt mäta hur stor del av hjärtmuskeln som riskerade att dö vid hjärtinfarkten. Dessa nya metoder kan användas för att minska skillnader mellan mätningar gjorda av olika läkare, på olika sjukhus och i olika forskargruppIn this thesis four new algorithms are presented for automatic segmentation in cardiovascular magnetic resonance (CMR); automatic segmentation of the left ventricle, myocardial infarction, and myocardium at risk in two different image types. All four algorithms were implemented in freely available software for image analysis and were validated against reference delineations with a low bias and hig

Popular Abstract in Swedish Hos människan lever en rad mikroorganismer som tillsammans utgör normalfloran. Normalfloran återfinns på alla kroppsytor, det vill säga huden och slemhinnorna i munnen, svalget, magsäcken, tunn- och tjocktarmen, vagina och urinrörsmynningen. Samspelet mellan människokroppen och mikroorganismerna utsätts dagligen för påfrestningar. En sådan naturlig påfrestning är de sjuThis thesis is concerned with a family of bacterial surface proteins expressed by different strains of the anaerobic Gram-positive, commensal and human pathogen Peptostreptococcus magnus. These proteins have been studied with respect to their role in virulence, function, structure, and evolution. Strains isolated from patients with vaginosis have previously been shown to be associated with express

Popular Abstract in Swedish Elakartade (maligna) blodsjukdomar uppstår i den blodbildande benmärgen, vilken är innesluten i hålrummen i de skelettdelar som kan sägas täckas av en badmössa och en gammaldags baddräkt. En av de celltyper som bildas i benmärgen är plasmacellen, en vit blodkropp som utgör mindre än 2% av benmärgscellerna och som tillverkar specifika antikroppar vid infektioner. Vid monAcquired genetic changes have proved to be of diagnostic and prognostic importance in different hematologic malignancies as well as in some solid tumor types. However, although multiple myeloma (MM), an incurable disease, and its proceeding stage monoclonal gammopathy of undetermined significance (MGUS) are quite common, little is known about the karyotypic features of these plasma cell dyscrasias

Transplantation of embryonic dopaminergic neurones can ameliorate symptoms in Parkinson’s disease, but a major obstacle for clinical transplantations to overcome is the low survival (typically 5-10%) of implanted nigral neurones. If cell death in nigral grafts can be prevented, less embryonic tissue would be needed per transplantation session and hence more patients could receive intracerebral gra

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos västerländska kvinnor. I Sverige kommer var tionde kvinna att drabbas av bröstcancer, vilket motsvarar drygt 5000 kvinnor om året. Dödligheten i bröstcancer är 30%. Detta innebär att en tredjedel av de som drabbas kommer att dö av sin sjukdom. Det är dock inte själva tumören i bröstet som dödar eftersom denna i princip alltBreast cancer is one of the most common cancer forms in the industrialized world. Only in Sweden, nearly 6000 women are diagnosed with breast cancer each year and 1/3 of them eventually succumb to the disease. Wnts are a family of genes that have been implicated in many human tumours, so far mainly studied in colorectal cancer where activated Wnt signalling occurs in a vast majority of tumours. Wh

Popular Abstract in Swedish Bukspottkörteln, pancreas, är ett viktigt organ för ämnesomsättningen. Dess viktigaste funktioner är att tillverka enzymer och bikarbonat som utsöndras till tolvfingertarmen, duodenum samt hormoner som utsöndras till blodbanan. De viktigaste enzymerna är amylas som bryter ned olika sockerarter och stärkelse, lipas som bryter ned fett och trypsin som bryter ned proteinerThe pancreas is a central organ in the digestion of food as well as in glucose metabolism. Its two major functions are exocrine and endocrine secretion. These are meticulously regulated processes that depend on hormonal response to gastrointestinal contents and blood glucose levels through feedback mechanisms, but also to the status of pancreas in health and diseases. The present thesis aimed at f

Popular Abstract in Swedish Vi kommer dagligen i kontakt med läkemedel i olika former, antingen som den kräm som vi smörjer in vårt onda knä eller Treon somliga tar på söndagsmorgon. Många av dessa produkter kan se enkla ut men är ofta resultatet av mycket forskning och för att förstå hur arbetet som utgör den här avhandlingen är kopplat till en Treo, så tänkte jag att vi ska börja med att förklarAn important issue within the pharmaceutical world today is the increasing number of poorly soluble drugs. These often show a low bioavailability and a susceptibility to varying conditions in the intestine. Hydrophobically modified poly (acrylic acid) (HMPAA), commercially available as Pemulen TR2, has shown promising abilities to control the release of especially poorly soluble substances. In thi

Popular Abstract in Swedish Pankreascancer, cancer i bukspottkörteln, är den fjärde vanligaste orsaken till död i cancer och årligen insjuknar cirka 1000 patienter i Sverige. Överlevnaden är kort med en 5-årsöverlevnad på endast 6 procent. Pankreascancer orsakar, förutom lidande, också betydande kostnader för såväl den medicinska vården, som förluster för samhället, exempelvis i form av förtida döBackground: Pancreatic cancer is the fourth leading cause of cancer-related death. Only about 6% of patients are alive 5 years after diagnosis. One reason for this low survival rate is that most patients are diagnosed at a late stage, when the tumor has spread to surrounding tissues or distant organs. Less than 20% of cases are diagnosed at an early stage that allows them to undergo potentially cu

Popular Abstract in Swedish Cellerna I vårt immunförsvar hjälper oss att eliminera olika typer av infektioner orsakade av parasiter, bakterier och virus. Ibland klarar dessa celler även av att ta bort tumörceller, kroppsegna celler som börjat att dela på sig okontrollerbart. Det måste betyda att cellerna i immunförsvaret kan se skillnad på kroppsegna celler och främmande celler och strukturer (antThe present study deals with natural killer (NK) T cells restricted to the antigen presenting molecule CD1d. NKT cells have been suggested to play a role in many diverse immunological situations such as clearance of different pathogens, protection against certain tumors, regulation of autoimmune reactions and as a link between innate and adaptive immune responses. NKT cells are in many respects un

Oilseed rape fields are a very common crop in the agricultural landscape of southern Sweden, and they can harbour surprisingly many insect species. Some of them are herbivores that feed on various parts of the oilseed rape plant, others are natural enemies of the herbivores, and even more species are tourists from the surrounding landscape. In my thesis I have studied these insects and how their pOilseed rape fields are a very common crop in the agricultural landscape of southern Sweden, and they can harbour surprisingly many insect species. Some of them are herbivores that feed on various parts of the oilseed rape plant, others are natural enemies of the herbivores, and even more species are tourists from the surrounding landscape. In my thesis I have studied these insects and how their p

Nya utbildningsministern ger svar Olika bud om säkerhet i fält Stulen dyrgrip åter i Lund Nya perspektiv TIMBUKTU OM ARBETET I LU:S KULTURRÅD LUNDS UNIVERSITETS MAGASIN | NR 5 | 2024 2 LUM NR 5 | 2024 LUM NR 5 | 2024 3 Kan sex veckors cykelpendling mellan Södra Sandby och Lund få LUM:s reporter att förvandlas från soffpotatis till supercyklist? Jag och tjugo andra testcyklister började den sex vec

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-10/LUM%205%202024%20.pdf - 2026-07-17

Nya utbildningsministern ger svar Olika bud om säkerhet i fält Stulen dyrgrip åter i Lund Nya perspektiv TIMBUKTU OM ARBETET I LU:S KULTURRÅD LUNDS UNIVERSITETS MAGASIN | NR 5 | 2024 2 LUM NR 5 | 2024 LUM NR 5 | 2024 3 Kan sex veckors cykelpendling mellan Södra Sandby och Lund få LUM:s reporter att förvandlas från soffpotatis till supercyklist? Jag och tjugo andra testcyklister började den sex vec

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-10/LUM%205%202024.pdf - 2026-07-17

Developing high-temperature proton exchange membranes (HT-PEMs) that simultaneously achieve high proton conductivity, strong phosphoric acid (PA) retention, and long-term chemical stability remains a major challenge, particularly due to PA-induced plasticization and radical-induced oxidative degradation. Here, we develop a side-chain engineering strategy to decouple PA-binding sites from the polym

Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c

This thesis presents structural and morphological studies of semiconductor nanostructures, namely quantum dots, nanowires and a dilute ferromagnetic semiconductor. These nanostructures are investigated on the atomic scale using cross-sectional scanning tunneling microscopy (XSTM). Indium arsenide (InAs) quantum dots in both an indium phosphide (InP) and GaAs matrix are studied. The InAs/InP quantu

Questions Can the model performance of the landscape reconstruction algorithm (LRA) for small forest hollows be validated through comparison to inventory-based vegetation reconstructions from the last 150yrs? Does the application of LRA and the comparison to historical data enhance interpretation of the pollen record? Location Denmark. The Gribskov-Ostrup small forest hollow (56 degrees N, 12 degr

During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a

The research area of climate field reconstructions has developed strongly during the past 20 years, motivated by the need to understand the complex dynamics of the earth system in a changing climate. Climate field reconstructions aim to build a consistent gridded climate reconstruction of different variables, often from a range of climate proxies, using either statistical tools or a climate model

Questions: To what extent does the long-term process of grassland succession reflect changes in nutrient availability or other effects of grassland history? Plant communities in ancient, semi-natural pastures include many species associated with nutrient-poor soils. However, semi-natural pasture communities can also develop on previously arable sites — as nutrient levels decline over time. In Euro