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SUMMARY: Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences. All downstream analyses such as choosing lead drug candidates depend on the correct annotation of these sequences; however, a thorough comparison of the performance of these tool
The Third Symposium, IAL 3, Progress and problems in lichenology in the nineties, Salzburg, Austria. 1–7 September 1996 Abstracts. Oral Presentation. Section B.
We consider normalized Boolean circuits that use binary operations of disjunction and conjunction, and unary negation, with the restriction that negation can be only applied to input variables. We derive a lower bound trade-off between the size of normalized Boolean circuits computing Boolean semi-disjoint bilinear forms and their conjunction-depth (i.e., the maximum number of and-gates on a direc
Striving to meet the challenges facing our society today, there is a growth in the number of cross‐sector collaboration. Expectations on these organizations are high in terms of their ability to deliver innovative solutions to wicked issues, but the task is challenging. This study contributes to our understanding of Triple Helix constellations and their ability to take on challenges related to com
H-infinity optimal control and estimation are addressed for a class of systems governed by partial differential equations with bounded input and output operators. Diffusion equations are an important example in this class. Explicit formulas for the optimal state feedback controller as well as the optimal state estimator are given. Unlike traditional methods for H-infinity synthesis, no iteration i
We introduce solution dependent finite difference stencils whose coefficients adapt to the current numerical solution by minimizing the truncation error in the least squares sense. The resulting scheme has the resolution capacity of dispersion relation preserving difference stencils in under-resolved domains, together with the high order convergence rate of conventional central difference methods
The clinical outcomes of primary immunodeficiencies (PIDs) are greatly improved by accurate diagnosis early in life. However, it is not common to consider PIDs before the manifestation of severe clinical symptoms. Including PIDs in the nation-wide newborn screening programs will potentially improve survival and provide better disease management and preventive care in PID patients. This calls for t
This thesis consists of three self-contained papers that all relate to the understanding of equality. The first chapter investigates the effects of preschool attendance on children in Kenya and Tanzania. We use a within-household estimator and data from nationally representative surveys of school-age children's literacy and numeracy skills, which include retrospective information on preschool att
A pulsed millimeter wave radar operating at a frame rate of 144 Hz is utilized to record 2160 scattering signatures of 12 generic hand gestures. Gesture recognition is achieved by machine learning, utilizing transfer learning on a pretrained convolutional neural network. This yields excellent classification results with a validation accuracy of 99.5%, based on a 60% training versus 40% validation
A range of cardiovascular risk factors associated with stroke are known, but they do not explain all cases of stroke. Genetic factors can be responsible for certain forms of stroke, and are further investigated in this thesis. The aims of this thesis were to study the occurrence of familial clustering of stroke, compile known stroke-associated genetic conditions for diagnostic and research genetic
In high-energy physics, Monte Carlo event generators (MCEGs) are used to simulate the interactions of high energy particles. MCEG event records store the information on the simulated particles and their relationships, and thus reflect the simulated evolution of physics phenomena in each collision event. We present the HepMC3 library, a next-generation framework for MCEG event record encoding and m
Design variables in density-based topology optimization are typically regularized using filtering techniques. In many cases, such as stress optimization, where details at the boundaries are crucially important, the filtering in the vicinity of the design domain boundary needs special attention. One well-known technique, often referred to as “padding,” is to extend the design domain with extra laye
Stefan Larssons kapitel placerar in dagens artificiella intelligens (AI) i sin digitala samtidshistoriska kontext — relationen till plattformar och internet som nätverk — och fördjupar därefter bilden av de mänskliga farhågorna med autonoma teknologier. Stefan visar på samspelet mellan databeroende AI och samhällets värderingar, och lyfter fram några av de demokratiska utmaningar som följer i kölv
The objective of this study is a non-invasive assessment of the thermal dose in hyperthermia. Electrical impedance tomography (EIT) has previously been given a first trial as a temperature monitoring method together with microwave-induced hyperthermia treatment, but it has not been thoroughly investigated. In the present work we have examined this method in order to investigate the correlation in
BACKGROUND: Staphylococcus lugdunensis belongs to the CoNS group, but is regarded to be more virulent than most other CoNS. It is also remarkably susceptible to antibiotics, including penicillin G. OBJECTIVES: To evaluate different methods for penicillin susceptibility testing, to assess penicillin susceptibility rates among S. lugdunensis and to describe the clinical presentation including antibi
This paper outlines promising avenues for empirical research on quantified control in healthcare work. A review of key insights from accounting, organization studies, and the emergent sociology of quantification indicates that numbers are productive as well as deceptive and seductive, that they enable control but can be evaded, and that they typically have unintended effects. It remains to be furt
Idag präglas många organisationer, inte minst i offentlig sektor, av ett starkt fokuspå regelverk, juridik, tekniska system och ekonomiska resultat. Utrymmet fördet mänskliga är begränsat. I denna bok samlar Louise Bringselius 22 krönikorpå temat människa, arbetsliv och samhälle och målar upp en vision om störreutrymme för det mänskliga. Boken kan användas som underlag för samtal omframtiden eller
