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An in vitro system with microdissected mouse islets was employed for studying insulin release. Islets from obese-hyperglycemic mice were considered particularly useful in view of their high content of adequately functioning β-cells. After freeze-drying and weighing each of the incubated islets it was possible to express the rate of insulin release per islet dry weight. Insulin released from a sing
We suggest a new multigrid preconditioning strategy for use in Jacobian-free Newton–Krylov (JFNK) methods for the solution of algebraic equation systems arising from implicit Discontinuous Galerkin (DG) discretisations. To define the new preconditioner, use is made of an auxiliary first-order finite volume discretisation that refines the original DG mesh, but can still be implemented algebraically
Conformational entropies are of great interest when studying the binding of small ligands to proteins or the interaction of proteins. Unfortunately, there are no experimental methods available to measure conformational entropies of all groups in a protein. Instead, they are normally estimated from molecular dynamics (MD) simulations, although such methods show problems with convergence and correla
Vehicle traffic management is becoming more complex due to increased traffic density in cities. Novel solutions are necessary for emergency vehicles, which despite growing congestion must be able to quickly reach their destination. Emergency vehicles are usually equipped with transmitters to control the traffic lights on their path and warn other vehicles with sirens. Transmitters are operated man
Digitally animated characters are promising tools in research studying how we integrate information from speech and visual sources such as gestures because they allow specific gesture features to be manipulated in isolation. We present an approach combining motion capture and 3D-animated characters that allows us to manipulate natural individual gesture strokes for experimental purposes, for examp
Plastics have become ubiquitous in modern society. It is a group of materials that is versatile and useful in many types of applications and have thus become extremely popular. Plastics are thus important for many industries and value chains as well as for everyday practices of most individuals – and should thus be also for investors and financial actors. A transition to sustainable plastics will
Accurate prediction of ship speed for given engine power and encountering sea environments is one of the key factors for ship route planning to ensure expected time of arrivals (ETA). Traditional methods need first to compute a ship's total resistance based on theoretical calculations, which are often associated with large uncertainties. In this paper, two statistical approaches are investigated t
We consider the analysis of continuous repeated measurement outcomes that are collected longitudinally. A standard framework for analysing data of this kind is a linear Gaussian mixed effects model within which the outcome variable can be decomposed into fixed effects, time invariant and time‐varying random effects, and measurement noise. We develop methodology that, for the first time, allows any
We study membership in Lipschitz classes (Formula presented.) for a class of α-harmonic functions in the open unit disc (Formula presented.) in the complex plane. From earlier work by Olofsson and Wittsten we know that such an α-harmonic function u is the α-harmonic Poisson integral (Formula presented.) of its boundary value function f on the unit circle (Formula presented.). We determine when the
Healthy cortical bone tissue is both tough and strong and has a unique ability to resist fracture. One reason is the hierarchical structure of the tissue where toughening mechanisms at all length scales act to slow down or stop a propagating crack. The most potent toughening mechanisms arise at the microscale when cracks interact with the osteonal microstructure and deflect along weak interfaces.
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history was re-evaluated, and diagnostic biopsies were re-examined. Furthermore, intralesional EBV-DNA was quantitated and HPV status d
The aim of this work is the development of a thermodynamically consistent fully coupled finite-strain thermo-viscoplastic material model for metals. The model is based on a split of the free energy into a thermo-elastic, a thermo-plastic and a purely thermal part and covers nonlinear cold-work hardening and thermal softening. Nonlinear temperature dependent effects are accounted for the elastic mo
Introduction: A laparotomy is commonly required to gain abdominal access. A safe standardized access and closure technique is warranted to minimize abdominal wall complications like wound infections, burst abdomen and incisional hernias. Stitches are recommended to be small and placed tightly, obtaining a suture length-to-incision length (SL/WL) ratio of ≥ 4:1. This can be time-consuming and diffi
