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The use of virtual learning environments is increasing, and it raises the question of how the environments are designed to benefit learning outcomes. The Cognitive Load Theory is a well-established framework for instructional design of learning environments, and introduces different design principles, based on a working memory model. This paper describes how these principles can be used in the des
Pretrained language models are integral part of AI applications, but their high computational cost for training limits accessibility. Initiatives such as Bloom and StarCoder aim to democratize access to pretrained models for collaborative community development. Despite these efforts, such models encounter challenges such as limited multilingual capabilities, risks of catastrophic forgetting during
This book describes the basic techniques required in learning structural biology. Apart from the classical and standard approaches like X-ray crystallography and SAXS (small angle X-ray scattering), it has quite an extensive chapter on the most recent approach; namely, cryo Electron Microscopy. The material is partly pedagogical, allowing readers to learn the subject, including some advanced topic
PURPOSE: To develop Mexico's first methodologically rigorous clinical practice guideline for the management of adult overweight and obesity. The target audiences are interdisciplinary healthcare professionals across healthcare systems who are the first point of contact for patients with obesity in Mexico, patients, and health system decision makers.RECENT FINDINGS: A review of recent international
När vi pratar om mobilitet tänker många på bussar, tåg och bilar. Men på landsbygden handlar mobilitet om något större: tillgång till livet. Dagens sätt att mäta transporter är utformat för städer och fokuserar på kostnad per passagerare och restid. Dessa mått fungerar dåligt i glesbygd, där avstånd inte är ett val utan en geografisk realitet. Människor kör bil ofta för att det helt enkelt saknas
Shifting the concept of municipal wastewater treatment to recover resources is one of the key factors contributing to a sustainable society. A novel concept based on research is proposed to recover four main bio-based products from municipal wastewater while reaching the necessary regulatory standards. The main resource recovery units of the proposed system include upflow anaerobic sludge blanket
Project Psyche is a transnational initiative to generate and study chromosome-level reference genomes of all ~11 000 species of Lepidoptera (butterflies and moths) found in Europe. Here, we describe the decentralised network of collection and sequencing hubs that has enabled rapid progress, the standardised protocols for sampling and sequencing, and the collaborative framework for data analysis. W
Bark beetle species of the genera Ips and Dendroctonus represent a threat to forests in both North America and Europe. Under normal circumstances, these beetles recycle dying trees into nutrients, but under certain conditions, growing populations can overcome healthy tree defenses and cause severe economic loss in forestry. The most economically relevant bark beetle species communicate with aggreg
Introduction: The Chilean Society of Bariatric and Metabolic Surgery, together with other scientific societies, led a process for adapting the Canadian clinical practice guideline for obesity in adults for Chile. The aim of the Canadian guideline, among its main objectives, was to propose changes in obesity management using a chronic disease framework and focusing on improving patient-centered hea
Rising populations are placing significant strain on traditional waste management, prompting the need for circular systems in urban projects to recycle valuable nutrients from wastewater. Introducing a biorefinery framework, microalgae cultivation on digestate effluents produces pigments for natural dyes, reducing nutrient release and offering eco-friendly alternatives to synthetic products. Succe
Atmospheric inversions are widely used to evaluate and improve inventories of methane (CH4) emissions across scales from global to local, combining observations with atmospheric transport models. This study uses the dense network of in situ stations of the Integrated Carbon Observation System (ICOS) to explore how well in situ data can constrain European CH4 emissions. Following the concept of int
The high neutron flux of the European Spallation Source in Lund, Sweden, opens new possibilities for neutron protein crystallography. Making full use of these gains requires dedicated instrumentation and support facilities to maximize its contribution to our understanding of biological processes at the molecular level.
The chapter argues that employees play a central yet historically overlooked role in organizational crisis communication. Traditional crisis communication has emphasized external stakeholders and managerial control, but this chapter highlights internal communication as a continuous, relational, and sensemaking process that shapes organizational legitimacy. Employees are portrayed as active sensema
Background: Tumor multiplicity is a negative prognostic factor in intrahepatic cholangiocarcinoma (iCCA) and the role of surgical resection in multiple iCCA remains unclear. Patients and Methods: Data were extracted from the Swedish quality registry for cancers of the liver and biliary tract, for all patients undergoing surgery for iCCA (2010–2021). Validation was performed with all Swedish hepato
Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors v
