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Chromosome banding analyses reveal secondary chromosome abnormalities in addition to the MYC translocations t(8;14)(q24;q32), t(8;22)(q24;q11), and t(2;8)(p11;q24) in 60%-80% of Burkitt lymphomas/leukemias (BL). The high incidence of such aberrations indicates that additional changes are important, perhaps necessary, for malignant transformation, i.e., the 8q24/MYC rearrangements may not be suffic

BRAF and NRAS mutations are frequently found in melanoma tumours and recently developed BRAF targeted therapies demonstrate significant clinical benefit.

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion

Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa

Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression. The miR-145 levels, measured by quantitative reverse transcription-polymerase chain reaction, wer

Early detection of prostate cancer (PC) using prostate-specific antigen (PSA) in blood reduces PC-death among unscreened men. However, due to modest specificity of PSA at commonly used cut-offs, there are urgent needs for additional biomarkers contributing enhanced risk classification among men with modestly elevated PSA.

Background/Aims: We examined the potential impact of vascular risk factors including copeptin - a robust surrogate marker of arginine vasopressin associated with the metabolic syndrome and diabetes risk - on future cognitive abilities in a population-based cohort. Methods: Participants (n = 933) were investigated using baseline data, including copeptin levels, and data collected 16 years later usi

To examine if overall diet quality is associated with cellular and soluble biomarkers of systemic inflammation in middle-aged individuals.

Factors affecting serum prostate-specific antigen (PSA) levels in men are clinically important, but apart from effects mediated through the androgen receptor, they are poorly understood.

Little is known about the fate and uptake of nanoplastics (NPs) in natural ecosystems, mainly due to analytical limitations in measuring NPs in complex environmental matrices. Our aim was to quantitatively assess the transport, fate and biological uptake of NPs in freshwater ecosystems by using replicated wetland mesocosms and gold-doped polystyrene nanoparticles. We showed that 97% of the NPs wer

Background: A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. The complement system can function as a bridge between innate and adaptive immune responses. Combining radiotherapy and complement activating therapy is theoretically interesting

High-speed vertical III–V nanowire transistors utilize their channel material for high frequency and low noise performance. A device layout revision to optimize gate resistance, in a trade-off to gate-source capacitance, is presented. A two-step redesign of the established device layout is proposed. First step is demonstrated with fabricated structures. The second step predicts the design transiti

Cracks in concrete compromise structural integrity by exposing steel reinforcement to corrosion agents, shortening its service life. Fungal-induced calcium carbonate (CaCO3) precipitation via urea hydrolysis offers a fast and robust self-healing mechanism to seal the cracks, extending the lifespan while reducing the carbon (C) footprint of concrete infrastructure. However, current studies rely on

OBJECTIVE: This study investigated trajectories of patient acceptable symptom state (PASS) among participants of a digital education and exercise therapy for knee and hip osteoarthritis.METHODS: A longitudinal observational study among individuals aged 40+ years who participated in the digital program. Participants completed PASS (yes/no) at enrolment and at least one follow-up during one year aft

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fl

Objectives: To determine clinical characteristics, outcome and occurrence of comorbidities in patients with biopsy-confirmed giant cell arteritis (GCA) treated with intravenous methylprednisolone (IVMP) vs those receiving oral glucocorticoids (OGC) only. Methods: A retrospective study included patients with GCA diagnosed from 2004 through 2019. Clinical and laboratory characteristics, and cumulati

The influence of alkyl chain on the physical and photochemical properties of D-A-π-A-π-A sensitizers (GZ-121 and GZ-124) for dye-sensitized solar cells (DSSCs) was investigated through density functional theory (DFT). Key aspects examined include geometry, optical characteristic, electron injection, intramolecular charge transfer, and dye regeneration. Adsorption models of dye@TiO2, short-circuit

Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n