Sökresultat

The spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown that the hallmark pathological proteins TAR DNA binding protein of 43 kDa (TDP-43) in FTD/ALS and mutant huntingtin (mHTT) in HD may be interlinked. Furthermore, these disorders share early

Research question: To what extent do ROC, EBIT growth, leverage ratio and FCF margin explain variations in stock returns among the 50 largest companies listed on the Stockholm Exchange during the period 2014 - 2024. Purpose: The purpose of this study is to examine the relationship between the financial ratios ROC, EBIT growth, leverage ratio and FCF-margin and stock price development among the 50

The International Agency for Research on Cancer has recently classified occupational exposure as a firefighter as carcinogenic (group 1A). Even though the occupation of firefighter is associated with high exposure to pollutants, it is challenging to carry out exposure studies to assess health risks due to the extreme conditions associated with firefighting. Routine monitoring of occupational expos

Smart microscopy represents a paradigm shift in biological imaging, moving from passive observation tools to active collaborators in scientific inquiry. Enabled by advances in automation, computational power, and artificial intelligence, these systems are now capable of adaptive decision-making and real-time experimental control. Here, we introduce a theoretical framework that reconceptualises sma

BACKGROUND: Ageing is associated with circadian rhythm sleep disorders, poor sleep at night, less physical activity and more time spent indoors, affecting the wellbeing of older adults. Their sleep and mood could benefit from daytime outdoor physical activity, exposure to daylight, better indoor lighting and sleep routines. However, changes to routines can be challenging depending on individual be

Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target TE families or unique TE loci. We also detail procedures for validating the efficiency and specificity of large-scale CRISPRi-based silencing using a multiome approach combining bulk RNA sequencing, C

AIMS: To build a comprehensive biobank integrated in the Swedish Heart Failure Registry (SwedeHF) comprising comprehensive clinomic data, proteomic, transcriptomic and genomic information in combination with clinical and diagnostic characteristics and additional ICD-code registry data.METHODS: Blood and urine samples will be biobanked at SwedeHF registration with an optional second sampling after

251031_MAA_samlet_25_15_digital.indd A Malmö Art Academy 2024 –2025 Management Maj Hasager Rector Silvana Hed Head of Administration Administration Charlotta Österberg Economy Madeleine Bergquist Librarian Marjaana Kinnunen Programme administrator Amanda Pettersson Communication officer Evalena Tholin Gallery coordinator and administrator Technicians Ariel Alaniz Metal, wood and sculpture workshop

https://www.khm.lu.se/sites/khm.lu.se/files/2025-12/251031_MAA_samlet_25_15_digital_sider_LQ.pdf - 2026-06-03

Emerging evidence suggests that bidirectional lung–kidney crosstalk may influence outcomes, but this has not been systematically evaluated in unselected emergency department populations. We therefore examined the association between peripheral oxygen saturation (SpO₂), estimated glomerular filtration rate (eGFR), and 30‑day mortality, and tested whether the prognostic association of oxygenation wi

Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma

Morgondagens energisystem står inför stora utmaningar och snabba förändringar både i Sverige och i världen. För att nå ambitiösa klimatmål ses elektrifiering som en viktig lösning på problemen, där Svenska Kraftnät räknar med en nära fördubbling av efterfrågan på el till 2045. Denna ökning, till stor del driven av förnybara energikällor som är svårare att planera och pronosticera, innebär betydandThe energy system of tomorrow faces major challenges and rapid changes both in Sweden and worldwide. To achieve ambitious climate targets, electrification is seen as a key solution, with the Swedish TSO projecting a near doubling of electricity demand by 2045. This increase, driven largely by renewable and intermittent energy sources, poses significant challenges for grid stability. Consequently,

Title: ABILITY > KNOWLEDGE - Can Learning Organizational Qualities be trained in the school system through Supplemental Instruction, and if so, how early? Issue of Thesis: The acceleration of the amount of knowledge that an organization in the 21st century needs to process is growing with exponential numbers. In order to survive, the organizations need to transform themselves into Learning Organi

In an effort to improve our understanding of the etiology and treatment of disorders involving symptoms of anxiety and depression, researchers have set out to identify psychological traits that may leave an individual vulnerable to experiencing intense negative emotional reactions. Included among these vulnerabilities are a person’s ability to tolerate negative emotional states (Distress Tolerance

Failures due to instability phenomena will happen suddenly and can cause the whole structure to collapse. It’s therefore in the engineer’s best interest to have a good knowledge about these phenomena. One example of instability phenomena is column buckling, which is the main focus of this thesis. The main cases that are being evaluated have a single brace in the middle of a timber column with hi

Arbetstagarskyddet vid verksamhetsöverlåtelser regleras inom Europeiska unionen (EU) av Rådets direktiv 2001/23/EG av den 12 mars 2001 om till-närmning av medlemsstaternas lagstiftning om skydd för arbetstagares rättig-heter vid överlåtelse av företag, verksamheter eller delar av företag eller verk-samheter (överlåtelsedirektivet). I svensk rätt har reglerna implementerats ge-nom ändringar i lag (The protection of employees in the case of business transfers is regulated within the European Union (EU) by Council Directive 2001/23/EC of 12 March 2001 on the approximation of the laws of the Member States relating to the safeguarding of employees’ rights in the event of the transfer of under-takings, businesses or parts of undertakings or businesses (Transfer of Un-dertakings directive). In Sw

Talking about inclusion in the workplace is an emerging concept, and the pressure of committing to work with it rests on the companies. The research conducted around inclusion is growing, and there are different suggestions as to how to define and work with the concept. Moreover, companies are lacking evidence to support how to successfully measure it among employees. By exploring inclusion in a s

https://www.htbibl.lu.se/article/meddelanden-fraan-ht-biblioteken-oktober-2024/ - 2026-05-30