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Genome-wide-association studies have identified numerous BMI-associated variants, but it is unclear how these relate to weight gain in adults at different ages.
Androgen receptor (AR) is expressed in all stages of prostate cancer progression, including in castration-resistant tumors. Eliminating AR function continues to represent a focus of therapeutic investigation, but AR regulatory mechanisms remain poorly understood. To systematically characterize mechanisms involving microRNAs (miRNAs), we conducted a gain-of function screen of 1129 miRNA molecules i
The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody
OBJECTIVE: Serum and glucocorticoid regulated kinase 1 (SGK1) expression is increased by aldosterone and is a key regulator of the amiloride-sensitive sodium channel (ENaC) in the distal nephron. We have previously shown that two SNPs in SGK1 (rs1057293 and rs1743966) are associated with blood pressure variation and blood pressure progression in the general population. Therefore, we tested the ass
To identify stop-codon variants associated with blood pressure (BP).
AIMS: To study HLA-DQB1 genes and islet cell autoantibodies against glutamic acid decarboxylase 65 (GADA) and insulinoma antigen-2 (IA-2A) in relation to diabetes post partum in mothers with diagnosed gestational diabetes mellitus (GDM). METHODS: During 2003-2004, women undergoing a 75g oral glucose tolerance test (OGTT) during pregnancy were invited to participate in the Mamma Study. Cut-off leve
Failures due to instability phenomena will happen suddenly and can cause the whole structure to collapse. It’s therefore in the engineer’s best interest to have a good knowledge about these phenomena. One example of instability phenomena is column buckling, which is the main focus of this thesis. The main cases that are being evaluated have a single brace in the middle of a timber column with hi
Arbetstagarskyddet vid verksamhetsöverlåtelser regleras inom Europeiska unionen (EU) av Rådets direktiv 2001/23/EG av den 12 mars 2001 om till-närmning av medlemsstaternas lagstiftning om skydd för arbetstagares rättig-heter vid överlåtelse av företag, verksamheter eller delar av företag eller verk-samheter (överlåtelsedirektivet). I svensk rätt har reglerna implementerats ge-nom ändringar i lag (The protection of employees in the case of business transfers is regulated within the European Union (EU) by Council Directive 2001/23/EC of 12 March 2001 on the approximation of the laws of the Member States relating to the safeguarding of employees’ rights in the event of the transfer of under-takings, businesses or parts of undertakings or businesses (Transfer of Un-dertakings directive). In Sw
Horizon Europe has identified climate-neutral and smart cities as one of its mission areas. In Sweden, the national innovation programme Viable Cities has set its sights on realising climate neutrality in cities by 2030. In both cases, a mission-oriented approach focused on citizens as drivers of climate action represents a pathway to success. However, citizen involvement has been presented as an
The investing industry has historically been built around the sole purpose to bring superior financial returns to investors. Due to the rising concern towards global social and environmental issues, investments promoting sustainable development have grown popular. Centring sustainable investments debate is the strategy impact investing. The strategy originates from more traditional ethical investm
The EU was initially created as an area of free trade amongst its Member States, its main objective is the realization of the full integration of the internal market. Of central importance to the objective is the fundamental freedoms and thereby the free movement of goods. However, in recent decades issues of an environmental nature have become more prevalent within the EU legal order and a framew
In the Lutheran tradition, of which the Church of Sweden is part, the spoken and written word often gets an automatic priority over the experience and perception of artistic expression. As a result, the discourse on the role of aesthetics in liturgical formation has come second to the ongoing discussion about the linguistic and semantic meaning of texts. This thesis wants to contribute to a renewe
The banking and financial services industry is experiencing a significant transformation driven by factors such as regulatory changes, customer demands, and the growing focus on data. This evolution has given rise to the concept of open finance, an extension of open banking that encompasses various financial sectors. Open finance aims to promote data sharing and access across the industry, with th
Syfte: Syftet med studien är att identifiera vad som definierar ett framgångsrikt byggprojekt och vilka framgångsfaktorerna är för att säkerställa att projektet enligt beställaren blir framgångsrikt. Vidare är syftet att undersöka hur kravställningen i de administrativa föreskrifterna påverkar ett projekts framgång. Frågeställningar: • Hur definierar beställaren ett framgångsrikt projekt? • Vilka
Popular Abstract in English Large market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of stLarge market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of staying competitive in this co
To investigate if diet quality is related to incidence of cardiovascular (CV) events.
A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators
