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Background: Mesenchymal stromal cells (MSCs) are currently being evaluated in numerous pre-clinical and clinical cell-based therapy studies. Furthermore, there is an increasing interest in exploring alternative uses of these cells in disease modelling, pharmaceutical screening, and regenerative medicine by applying reprogramming technologies. However, the limited availability of MSCs from various

Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of t

Chronic myeloid leukemia (CML) is genetically characterized by the Philadelphia (Ph) chromosome, formed through a reciprocal translocation between chromosomes 9 and 22 and giving rise to the constitutively active tyrosine kinase P210 BCR/ABL1. Therapeutic strategies aiming for a cure of CML will require full eradication of Ph chromosome-positive (Ph(+)) CML stem cells. Here we used gene-expression

The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and C

Ultrafast science refers to physical events that happen on the femtosecond (1 fs=10^-15 s) and attosecond (1 as=10^-18 s) timescales. Generation of attosecond pulses is usually achieved by interacting high-intensity femtosecond pulses with matter (typically gases), in a process called high-order harmonic generation (HHG). Under the correct conditions, this process leads to the creation of sub-fs p

Responsibility to Protect is a principle that has developed from a report written by ICISS in 2001. The report was inspired by a statement of Kofi Annan where he questioned how the international community would stop another incident like Rwanda or Srebrenica. Since then many situations have occurred that has challenged the concept of R2P. The debate about humanitarian interventions based on intern

The question of environmental protection has lately become essential due to the increased number of polluters and accidents that have occurred in recent decades. The starting point was the Torrey Canyon disaster which happened in March 1967 and exposed the entire international community to a great danger of environmental harm in general and marine pollution in particular. The accident also pointed

In the beginning of the 1990’s community service was introduced at a couple of Swedish courts as an experiment. It was to be a compliment to probation and together the two were supposed to be considered the equivalent in harshness of a shorter prison sentence. After a few years the experiment was extended to all Swedish courts and by the end of the decade community service was made a permanent par

Economic sanctions are defined as the exercise of pressure by one state to produce a change in the political behaviour of another state. Traditional economic sanctions are directed at the entire population of a state whilst targeted sanctions are directed at a state’s individuals. This thesis discusses the application of economic sanctions against Iran by the UN, the EU and the United States. Econ

Artificial intelligence (AI) is rapidly transforming healthcare, yet its successful integration depends heavily on the acceptance and understanding of this technology by medical professionals. Our qualitative exploratory study, using semi-structured interviews with eight medical professionals in Sweden and Denmark, charts their perceptions of AI's implementation in medicine. The primary goal o

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clin

Immune checkpoint inhibitors (ICIs), targeting checkpoint receptors such as programmed cell death protein 1 (PD-1), are associated with increased risk of cardiovascular events, but the underlying mechanisms remain poorly understood. Here we show that PD-1 + T cells from murine atherosclerotic aortas mainly display a progenitor exhausted phenotype (PD-1 intSlamf6 +Tim3 -), produce IFNγ in vivo, exh

Knowledge about food structures at different length scales is key for the continued development of sustainable, tasty and healthy foods. It is critical to control, model and predict the supramolecular architecture of foods along the whole value chain: from raw materials, to their changes during processing, all the way to how products form structures during consumption and digestion. Today, advance

This work shows a contribution to a long-term study of lead in smelter workers where the objectives were to assess the historical lead (Pb) exposure and to study the relationships between lead concentrations in finger bone (Bone-Pb), whole blood (B-Pb), plasma (P-Pb), urine (U-Pb) and the duration of employment in workers at a secondary lead smelter. Moreover, results were compared with previous s

Cell polarity is an ubiquitous and important phenomenon relevant for a plethora of cellular functions. One type of cell polarity is polar growth, where an organism only synthesizes cell envelope at designated locations in the cell. This requires highly organized localization of cellular activities. Understanding the ways in which polarity and polar growth are organized is critical for understandin