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To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-codi

Genomic sequencing of avian haemosporidian parasites (Haemosporida) has been challenging due to excessive contamination from host DNA. In this study, we developed a cost-effective protocol to obtain parasite sequences from naturally infected birds, based on targeted sequence capture and next generation sequencing. With the genomic data of Haemoproteus tartakovskyi as a reference, we successfully s

As diets change in response to ethical, environmental, and health concerns surrounding meat consumption, fermentation has potential to improve the taste and nutritional qualities of plant-based foods. In this study, cauliflower, white beans, and a 50:50 cauliflower-white bean mixture were fermented using different strains of Lactobacillus plantarum. In all treatments containing cauliflower, the pH

Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.

Background: Early trials have reported a beneficial effect from tamoxifen treatment in patients with unresectable pancreatic cancer, in particular in women. However, the presence and prognostic significance of female hormone receptors in pancreatic or other periampullary cancers has not yet been described. Methods: Immunohistochemical screening of normal and malignant pancreatic tissue revealed t

It has been proposed that hyaluronan-binding proteoglycans play an important role as guiding cues during neural crest (NC) cell migration, but their precise function has not been elucidated. In this study, we examine the distribution, structure and putative role of the two major hyaluronan-binding proteoglycans, PG-M/versicans and aggrecan, during the course of avian NC development. PG-M/versicans

Today, the underlying theoretical and methodological foundations as well as implementations in the field of accessibility are largely based on plans, metrics and heuristics. There is an obvious tension between these norms and those of the overall spirit of the times, which leans heavily towards improvisations, diversity, and ever-changing affordances. The parallel evolution of human computer inter

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture physiological and functional tumor processes, were evaluated as imaging surrogates of early tumor response following chemoradiotherapy in glioma patients. A multiparametric extension of a voxel-based analysis, referred as the parametric response map (PRM), was applied to quantitative MRI maps to test the predictive poten

Recensionen av Wilhelm Agrells Vem kan man lita på? – Den globala övervakningens framväxt fick titeln ÖVERVAKNINGSSYSTEMENS INNEBOENDE TENDENS ATT EXPANDERA. Publicerades i nr 6, 2015, av tidskriften Respons. Recensent Stefan Larsson.

The goal of this paper is to discuss current problems of education for sustainable development, i.e. a global educational innovation that is actively growing in the new century. In Sweden, which has extensive experience in ecological education, education for sustainable development is considered a national model for the creation of the foundation for SD. In Russia, difficulties exist in defining a

Popular Abstract in Swedish NÄR ÖRESUNDSBRON INVIGDES ÅR 2000 nådde förväntningarna på dansk-svensk integration sin kulmen. Prognoser och framtidsspekulationer haglade. Nyhetsbrev, reklamkampanjer, webbplatser och konferenser producerades på löpande band. Öresundsbron förenade Öresundsregionen. Öresundsregionen förenade skåningar och själlänningar. Tillsammans skulle de forna broderfolken skapa enThe Öresund Bridge between Denmark and Sweden was inaugurated in the year 2000, connecting the city of Malmö and the Danish capital Copenhagen. The bridge was an important move towards the visionary realisation of a transnational Öresund Region. In this dissertation the communicative aspects of the regional process are put in focus. The vision of the Öresund Region that developed during the 1990s