Filtyp
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai
BackgroundRight ventricular (RV) function is a major determinant of outcome in patients with pulmonary hypertension. Cardiac magnetic resonance (CMR) is gold standard to assess RV ejection fraction (RVEFCMR), however this is a crude measure. New CMR measures of RV function beyond RVEFCMR have emerged, such as RV lateral atrio-ventricular plane displacement (AVPDlat), maximum emptying velocity (S’C
Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate
The aim was to evaluate volume, diffusion, and perfusion metrics for better presurgical differentiation between high-grade gliomas (HGG), low-grade gliomas (LGG), and metastases (MET). For this retrospective study, 43 patients with histologically verified intracranial HGG (n = 18), LGG (n = 10), and MET (n = 15) were chosen. Preoperative magnetic resonance data included pre- and post-gadolinium co
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) from the bone marrow into the blood. Identifying the genetic factors that control blood CD34+ cell levels could reveal new drug targets for HSPC mobili
The depletion of disruptive variation caused by purifying natural selection (constraint) has been widely used to investigate protein-coding genes underlying human disorders 1–4, but attempts to assess constraint for non-protein-coding regions have proved more difficult. Here we aggregate, process and release a dataset of 76,156 human genomes from the Genome Aggregation Database (gnomAD)—the larges
While organisms have evolved to cope with predictable changes in the environment, the rapid rate of current global change presents numerous novel and unpredictable stressors to which organisms have had less time to adapt. To persist in the urban environment, organisms must modify their physiology, morphology and behaviour accordingly. Metabolomics offers great potential for characterising organism
Oral assessment is an important method to evaluate the learning outcomes of scientific courses. However,there are certain limitations when oral assessment is applied.One of these limitations, which is not apparent in anonymous written exams, is the existence of biases which could lead to unfair (positive or negative) outcomes of the assessment. This could lead to decreased motivation and sense of
Recent studies of selective auditory attention have demonstrated that neural responses recorded with electroencephalogram (EEG) can be decoded to classify the attended talker in everyday multitalker cocktail-party environments. This is generally referred to as the auditory attention decoding (AAD) and could lead to a breakthrough for the next-generation of hearing aids (HAs) to have the ability to
In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK,
The intention of this thesis was to investigate autoimmune markers for type 1 diabetes, together with signs of enterovirus infections during the pre- and perinatal period of life, and their possible association with the development of diabetes during childhood, adolescence, and young adulthood. We found that: 1. Newborns with ABO immunization, linked in epidemiological studies with heightened diab
Popular Abstract in Swedish Samhällets stöd, service och vård till människor med psykiska funktionshinder har under de senaste decennierna genomgått stora förändringar. Det har skett en övergång från slutna till samhällsbaserade öppna vårdformer. De kraftiga nedskärningarna av den sjukhusbaserade psykiatriska vården har emellertid långt ifrån alltid ersatts med ett heltäckande och fungerande vård-All clients admitted to ten pilot case management services for individuals with severe mental illness during 1995 and up to 1996-09-30 were invited to participate in the present study. A total of 176 clients were included. The clients were in all services assessed at admission and at an 18 months follow-up with regard to needs of care, psychosocial functioning. Use of health care and social servic
Popular Abstract in English Nanotechnology is a quickly developing field, which applies objects of extremely small sizes to novel technological applications. These objects, so-called nanomaterials, have at least one dimension measured in nanometers, 10-9 meters. Nanoparticles are of interest to chemists due to their distinct properties, which differ significantly from the bulk material. This uniquTitanium dioxide and related oxide materials have been investigated using density functional theory calculations. Nanocrystalline particles were modelled by a finite cluster approach. The studies focus on the characterization of structural and electronic properties of TiO2 and related group-IV materials (SiO2, GeO2, SnO2), as well as, interactions on their surfaces. A set of bare cluster models o
Popular Abstract in Swedish Den svenska grundskolan har under de senaste åren genomgått och genomgår fortfarande en stark utveckling inom ramen för den allmänna decentraliseringen i samhället. Beslut och ansvar läggs allt längre ner i organisationen. De krav som ställdes på en skolledare tillbaka i tiden var i första hand att han skulle vara administratör och den som bevakade att skolans verk-samThe issues of the study are: How do the assistant principals face the work as school leaders? Which demands of competence do the new school leaders face? Which needs of competence development exist for new school leaders? In the school studied the organization of the management was changed from one principal and one director of studies to one principal and six assistant principals. All of these we
Fler får behålla bröstet med bröstbevarande operation – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Fler får behålla bröstet med bröstbevarande operation 2014-05-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Vid en bröstcanceroperation tar man bort sj
https://www.vetenskaphalsa.se/fler-far-behalla-brostet-med-brostbevarande-operation/ - 2026-06-07
1 Salstentamen 2025-09-30 SOCA74 Sociologi: kriminologi Delkurs 1: Vad är kriminologi (7,5 hp) Tentamen består av fem essäfrågor och tio multiple choice-frågor. Antalet möjliga poäng står angivet vid respektive fråga. Skriv ditt svar på varje fråga på separat skrivhäfte. Du skriver max 2 sidor till respektive essäfråga. Du skriver bara på linjerna. Försök ge utförliga, tydliga och välformulerade s
https://www.soc.lu.se/sites/soc.lu.se/files/2026-05/SOCA74_dk1_ordinarie.pdf - 2026-06-07
Brevmall Postadress xxxx Besöksadress xxxx Telefon xxxx, 046-222 00 00 Fax xxxx E-post xxxx Webbadress xxxx Handlingsplan vid dödsfall eller allvarlig personolycka Inledning Om en krissituation uppstår är det viktigt att alla vet hur de ska agera om vem som har ansvar för vad. Vid händelser som kräver omedelbara och samordnade åtgärder inom myndigheten Lunds universitet, i syfte att minimera konse
Varmt välkommen till BARN I FOKUS ETT VETENSKAPLIGT SYMPOSIUM OM BARNCENTRERAD VÅRD OCH E-HÄLSA Slutsymposium LUC3 28/11 - kl. 12:00-17:00 Under två delsymposium presenteras den forskning som bedrivits och implementerats inom LUC3 och den forskning som pågår och planeras inom eChildHealth de kommande sex åren. Symposium eChildHealth 29/11 - kl. 09:00-13:00 Sedan 2013 har forskare från Sverige, Dan
https://www.lu.se/sites/www.lu.se/files/barn_i_fokus_-_program_0.pdf - 2026-06-07
