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Traumatic brain injury (TBI) is a multidimensional and highly complex disease commonly resulting in widespread injury to axons, due to rapid inertial acceleration/deceleration forces transmitted to the brain during impact. Axonal injury leads to brain network dysfunction, significantly contributing to cognitive and functional impairments frequently observed in TBI survivors. Diffuse axonal injury
The semi-arid Sahel zone of Africa has suffered several periods of severe drought since about 1950. We have analyzed AVHRR Normalized Difference Vegetation Index (NDVI) over the Sahel for the period 1982-2002, and found extensive areas of increasing NDVI. To verify these changes we have analyzed Landsat TM and ETM+ scenes from 1984-1986 and 1999-2001 for areas in the Sudan, Central African Republi
We argue that there is a need for a more elaborate and sophisticated discussion of if, and then how, the public library fulfils its social role to con- tribute to democracy. Therefore, we have formed the Lund Critical Library Studies group with a shared interest of contributing to a more nuanced and rich discussion about public libraries. This allows us to engage in discussions on how the library
Cartilage oligomeric matrix protein (COMP) was recently implicated in the progression of breast cancer. Immunostaining of 342 prostate cancer specimens in tissue microarrays showed that COMP expression is not breast cancer-specific but also occurs in prostate cancer. The expression of COMP in prostate cancer cells correlated with a more aggressive disease with faster recurrence. Subcutaneous xenog
This study contains a series of laboratory experiments designed to describe the lateral movement and spatial variability of an infiltrated dye tracer across the capillary fringe of homogenous sand in an aquarium. A combination of image analysis and geoelectrical monitoring was used to track the flow paths of the dye with different hydraulic gradients and infiltration rates. Photographs were taken
A high resolution TPC is the main option for a central tracking detector at the future International Linear Collider (ILC). It is planned that the MPGD (Micro Pattern Gas Detector) technology will be used for the readout. A Large Prototype TPC at DESY has been used to test the performance of MPGDs in an electron beam of energies up to 6 GeV. The first step in the technology development was to demo
Acquired chromosome abnormalities in tumours often reflect pathogenetic events at the gene level. Multicolour fluorescence in situ hybridisation (FISH) with single-copy probes offers extensive possibilities to characterise chromosome breakpoints in relation to the physical map of the human genome. This approach is based on the construction of comprehensive EST- based maps, combinatorial labelling
Abstract in UndeterminedYou may think that your requirements engineering process is fairly limited and currently not too complex to manage. Or you may be right in the middle of a storm of requirements where it is impossible to manage even the most important ones comprehensively. If you are in the former situation, it may be dangerous to relax as many successful software-intensive products have a t
In animal models of Parkinson's disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute striatal slices from rodents with unilateral 6-hydroxydopamine (6-OHDA) lesions. Application of the dopa
Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognostic value of BSI during androgen deprivation therapy (ADT).
Description of how to do a semi-structured interviews of individuals
Hans Christian Andersen's tale "The Marsh King's Daughter" (1858) is analysed in relation to Birgitta Trotzig's prose tale of the same title, Dykungens dotter (1985), with the emphasis on Andersen's tale which would seem to be a pious Christian morality in which evil is destroyed and the powers of light conquer darkness. At the same time, Andersen's symbols make clear that darkness is a necessary
Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychot
The 8p11 myeloproliferative syndrome (EMS), also referred to as stem cell leukemia/lymphoma, is a chronic myeloproliferative disorder that rapidly progresses into acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in constitutive activation of the tyrosine kinases in FGFR1. To date, no previous study has addressed the functional conseq
Analytical solutions to 2D depth-averaged (external mode) and fully 3D (internal mode) periodic flows for numerical model testing are presented in this paper. These solutions take into account the effects of the bottom friction, the horizontal turbulent viscosity, and the vertical turbulent viscosity for the case of 3D flow. The key linkage for the modes is the relationship between the bottom fric
