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Current opportunities for clinical monitoring of axonal pathology in traumatic brain injury

Traumatic brain injury (TBI) is a multidimensional and highly complex disease commonly resulting in widespread injury to axons, due to rapid inertial acceleration/deceleration forces transmitted to the brain during impact. Axonal injury leads to brain network dysfunction, significantly contributing to cognitive and functional impairments frequently observed in TBI survivors. Diffuse axonal injury

Expanding Bioenergy in Europe

Despite apparently favourable conditions for investment in the bioenergy sector provided by sustained high oil prices and a multitude of policy support measures throughout the EU that are ostensibly intended to create improved economic conditions, many industrialists and investors are still apparently wary of engagement. National policy interventions intended to support and to expand the bioenergy

Krig och brott. Definitioner av kriminalitet i ett bosniskt efterkrigssamhälle

Syftet med rapporten är identifiera och analysera uppfattningar om brott i Bosnien under och efter kriget samt beskriva i vilken mån inblandande parter i en konflikt kan förlåta varandra eller försonas. Den empiriska delen av uppsatsen bygger på observationer i Ljubija, tidningsartiklar från området samt fjorton intervjuer. I analysdelen diskuteras det empiriska materialet med utgångspunkt från DuWhat is percieved as a crime in war time varies depending on the war at issue, the eventual peace, the victors and the victims. This study focuses on the resolution of rules that occured in Ljubija, a town in the north-western part of Bosnia-Herzegovina, during the the war 1992-1995, and how it created new conflicts and group formations that live on after the war. After the war a competition for t

Essential Tensions in the Field of Psychiatry

In this presentation I discuss modern psychiatry, esp. neuropsychiatry, from the perspectives of philosophy and sociology of science. It is argued that there exist a number of tensions and ‘incommensurabilities’ in the field that are hard to overcome, thus giving rise to controversies. I separate four types of tensions, belonging to different ‘boxes.’ The first is called cognitive/internal, compri

Fixation stability and implication for multifocal electroretinography in patients with neovascular age-related macular degeneration after anti-VEGF treatment

Purpose: To quantify fixation stability in patients with neovascular age-related macular degeneration (nAMD) at baseline, 3 and 6 months after anti-vascular endothelial growth factor (anti-VEGF) treatment and furthermore asses the implications of an unsteady fixation for multifocal electroretinography (mfERG) measurements. Methods: Fifty eyes of 50 nAMD patients receiving intravitreal anti-VEGF tr

In-Service Information Flows to Designers

This research is triggered by the emerging ‘power by the hour’® paradigm, in which aero engines are effectively leased to airlines, with the manufacturing company remaining responsible for their maintenance and repair throughout their service life. By incorporating knowledge about the performance of existing products into the design phase of new products, it is hoped to tackle some of the in-servi

Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient

The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem cell