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Escherichia coli BL21 (DE3) with a plasmid vector pET-22b (+) carrying xylanase coding gene isolated from an extremely thermophilic bacterium, Thermotoga sp. was used in this work for enhanced production of recombinant xylanase. The study was focused on optimization of lactose based induction for enhanced production of xylanase. Data collected from OFAT and DoE based trails indicated that initiati
Background: Evidence was found for the effectiveness of virtual reality-based cognitive behavioral therapy (VR-CBT) for treating paranoia in psychosis, but health-economic evaluations are lacking. Objective: This study aimed to determine the short-term cost-effectiveness of VR-CBT. Methods: The health-economic evaluation was embedded in a randomized controlled trial evaluating VR-CBT in 116 patien
We investigate the use of atmospheric oxygen (O2) and carbon dioxide (CO2) measurements for the estimation of the fossil fuel component of atmospheric CO2 in the UK. Atmospheric potential oxygen (APO) - a tracer that combines O2 and CO2, minimizing the influence of terrestrial biosphere fluxes - is simulated at three sites in the UK, two of which make APO measurements. We present a set of model ex
Background: Refugees and asylum-seekers have an elevated risk of mental health issues, such as depression and posttraumatic stress. Qualitative outcome studies can contribute by offering insight into patients’ experiences of what they find beneficial and how they undergo the process of recovery. This study aligns with the small body of qualitative research focusing on refugees’ perspectives of psy
The human gastrointestinal tract (GIT) is home to a large community of microorganisms that contribute to human health. Delivering live bacteria to the gut for therapeutic purposes can thus be highly beneficial. However, delivering live biotherapeutic products or probiotic bacteria to the GIT presents challenges because the cells must remain viable during production, storage, and administration. En
Optically stimulated luminescence (OSL) signal properties of pellets from three types of NaCl (two household salts and one analytical grade salt) were investigated for their use in prospective dosimetry. Special attention was given to the OSL signal behaviour with time. The readout protocol was optimised in terms of preheat temperature, and the OSL signal yield of the NaCl pellet with time as well
Background: More remains to be understood about attitudes towards treatment for gambling disorder and where to seek treatment. Given the low degree of treatment seeking behaviour in this condition, it may be of interest to study people’s perception about where to seek help in case of problem gambling. From a study originally aiming to address health correlates of problem gambling, the present sub-
An overview of housing assessment tools developed or adapted for research use in East and Southeast Asia is currently lacking. A scoping review was conducted to address this knowledge gap. PubMed, Web of Science and CINAHL were searched for relevant scientific literature, and 22 articles were selected. Besides study-specific checklists, two assessment tools validated for use in Asia and three vali
Operating lignocellulosic fermentation processes to produce fuels and chemicals is challenging due to the inherent complexity and variability of the fermentation media. Real-time monitoring is necessary to compensate for these challenges, but the traditional process monitoring methods fail to deliver actionable information that can be used to implement advanced control strategies. In this study, a
Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each review, two authors judged whether each predefined harm
Two-dimensional laser-induced incandescence (LII) measurements usually involve the use of a cylindrical lens to illuminate the planar region of interest. This creates a varying laser fluence and sheet width in the imaged flame region which could lead to large uncertainties in the quantification of the 2D LII signals into soot volume fraction distributions. To investigate these effects, 2D LII meas
A controlled, highly engineered landfill has many similarities to natural peatlands or other natural anoxic sediment deposits. In anaerobic MSW landfills, generally about 30-50 percent of the total carbon content in the waste can be converted into biogas and be collected as resource for energy or chemical industry. Remaining long-lived organic carbon, e.g. from lignin remains un-degraded, Organic
Background: Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecessary biopsies. Methods: Using a machine learning program, we identified a 25-Gene Panel classifier for distinguishing PCa and benign prostate. A non-invasive t
Background: Intravenous ferric carboxymaltose has been shown to improve symptoms and quality of life in patients with chronic heart failure and iron deficiency. We aimed to evaluate the effect of ferric carboxymaltose, compared with placebo, on outcomes in patients who were stabilised after an episode of acute heart failure. Methods: AFFIRM-AHF was a multicentre, double-blind, randomised trial don
Importance: Congenital heart disease (CHD) is the most common congenital malformation in humans worldwide. Circulating cardiovascular biomarkers could potentially improve the early detection of CHD, even in asymptomatic newborns. Objectives: To assess the performance of a dried blood spot (DBS) test to measure the cardiovascular biomarker amino terminal fragment of the prohormone brain-type natriu
The tragic failure of the global supply chain in the face of the current coronavirus outbreak has caused acute shortages of essential frontline medical devices and personal protective equipment, crushing fear among frontline health workers and causing fundamental concerns about the sustainability of the health system. Much more coordination, integration, and management of global supply chains will
