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Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic acidosis is very low in connection with administration of iodine contrast media, new recommendations in Sweden say that metformin must be stopped only when GFR iTreatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic a

Background: Many stroke survivors suffer from sensory impairments of their affected upper limb (UL). Although such impairments can affect the ability to use the UL in everyday activities, very little attention is paid to sensory impairments in stroke rehabilitation. The purpose of this trial is to investigate if sensory re-learning in combination with task-specific training may prove to be more ef

A search for W′-boson production in the W′→tb¯→qq¯′bb¯ decay channel is presented using 36.1fb−1 of 13 TeV proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search is interpreted in terms of both a left-handed and a right-handed chiral W′ boson within the mass range 1–5 TeV. Identification of the hadronically decaying top quark is perfo

A search for high-mass resonances decaying to τν using proton-proton collisions at s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb-1. No statistically significant excess above the standard model expectation is observe

Recent conceptual studies identify gain, normative and hedonic factors as three categories of motivations of consumer proenvironmental behavior. However, empirical understanding of how these motivations interact and affect proenvironmental behavior is limited. This study is based on a survey of car owners in Sweden (N = 573) and uses structural equation modeling to analyze the data. The empirical

Pt-Rh alloy nanoparticles on oxide supports are widely employed in heterogeneous catalysis with applications ranging from automotive exhaust control to energy conversion. To improve catalyst performance, an atomic-scale correlation of the nanoparticle surface structure with its catalytic activity under industrially relevant operando conditions is essential. Here, we present x-ray diffraction data

A search for the associated production of the Higgs boson with a top quark pair (ttH) is reported. The search is performed in multilepton final states using a data set corresponding to an integrated luminosity of 36.1 fb-1 of proton-proton collision data recorded by the ATLAS experiment at a center-of-mass energy s=13 TeV at the Large Hadron Collider. Higgs boson decays to WW∗, ττ, and ZZ∗ are tar

Review of Mats Burström, "Barlast. Massor med historia" (2017)

In species with complex life cycles, laboratory studies have shown that variations in the traits of settling larvae can affect post-settlement survival and influence recruitment and benthic- pelagic coupling. However, we still know little about the magnitude and spatial scale of natural trait variation. We studied spatial variation in body size and nutritional reserves (carbon, nitrogen and lipids

Lignocellulosic biomass is a promising alternative fuel source which can promote energy security, reduce greenhouse gas emissions, and minimize fuel consumption when paired with advanced combustion strategies. Pyrolysis is used to convert lignocellulosic biomass into a complex mixture of phenolic-rich species that can be used in a transportation fuel. Anisole (or methoxybenzene) can be used as a s

Objectives: Reperfusion immediately after reopening of the infarct-related artery in ST-segment elevation myocardial infarction (STEMI) may cause myocardial damage in addition to the ischaemic insult (reperfusion injury). The gap junction modulating peptide danegaptide has in animal models reduced this injury. We evaluated the effect of danegaptide on myocardial salvage in patients with STEMI. Met

Atherosclerosis and its clinical consequences are the leading cause of death in the western hemisphere. While many studies throughout the last decades have aimed at understanding the disease, the clinical markers in use today still fail to accurately predict the risks. The role of the current main clinical indicator, low density lipoprotein (LDL), in depositing fat to the vessel wall is believed t

This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait affecting only males, caused by mutations in the RS1 gene. Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfu

Introduction: The central question this study sought to answer was whether the team members of Strategic Crisis Teams (SCTs) participating in mass-casualty incident (MCI) exercises in the Netherlands learn from their participation. Methods: Evaluation reports of exercises that took place at two different times were collected and analyzed against a theoretical model with several dimensions, looking

Background: The consequences of lifestyle-related disease represent a major burden for the individual as well as for society at large. Individual preventive health checks to the general population have been suggested as a mean to reduce the burden of lifestyle-related diseases, though with mixed evidence on effectiveness. Several systematic reviews, on the other hand, suggest that health checks ta

The work presented in this thesis has aimed to improve the knowledge about the groundwater occurrence in different geological conditions in Mozambique. The main focus in this study has been on the understanding of hydrogeological conditions in area with little background information by use of geophysical investigation. The lack of background information is a problem in many countries because the