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We identified recently the extracellular matrix (ECM) receptor interaction pathway as a consistently overrepresented category among gene expression profiling studies on colorectal cancer (CRC) prognosis. Putative regulatory single nucleotide polymorphisms (SNPs) in genes from the ECM pathway were genotyped in 613 CRC patients from Northern Germany (PopGen cohort) and tested for association with di
Diabetes is one of the chronic diseases that constitute the greatest disease burden in the world. The Swedish National Diabetes Register is an essential part of the diabetes care system. Currently it mainly records clinical outcomes, but here we describe how it has started to collect patient-reported outcome measures, complementing the standard registry data on clinical outcomes as a basis for eva
Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, it is unclear whether mitochondrial dysfunction is a primary cause of the common form of diabetes. To date, common genetic variants robustly associated with type 2 diabetes (T2D) a
Dietary fats could affect glucose metabolism and obesity development and, thereby, may have a crucial role in the cause of type 2 diabetes (T2D). Studies indicated that replacing saturated with unsaturated fats might be favorable, and plant foods might be a better choice than animal foods. Nevertheless, epidemiologic studies suggested that dairy foods are protective.
Despite recent successes in the identification of genetic susceptibility loci, no familial risk has been demonstrated for childhood acute lymphoblastic leukaemia (ALL). We identified 3994 childhood ALL cases from two cancer registries; family members were obtained from population registers. The standardized incidence ratio for familial risk in singleton siblings and twins was 3.2 (95% confidence i
BACKGROUND: The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest. This pilot study assesses feasibility, safety, and intermediate clinical outcomes as part
The sometimes rapid development of (new) threats and extraordinary events calls for a robust, flexible, and well-equipped civil crisis preparedness system to respond and limit the damage of crisis events. To achieve this, Swedish municipalities and regions are required by law to regularly perform and report risk and vulnerability analysis ‘bottom up’ to governmental agencies. When performed in lar
ObjectiveDevelopment of an AI tool to assess velopharyngeal competence (VPC) in children with cleft palate, with/without cleft lip.DesignInnovation of an AI tool using retrospective audio recordings and assessments of VPC.SettingTwo datasets were used. The first, named the SR dataset, included data from follow-up visits to Skåne University Hospital, Sweden. The second, named the SC + IC dataset, w
This study reports on the effects of conformationally controlled amphiphilicity of antimicrobial peptides (AMPs) on their ability to coat TiO2 nanoparticles (NPs) and boost the photocatalytic antimicrobial effects of such NPs. For this, TiO2 NPs were combined with AMP EFK17 (EFKRIVQRIKDFLRNLV), displaying a disordered conformation in aqueous solution but helix formation on interaction with bacteri
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10−8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing to
Our theme for this bachelor’s thesis is to take a closer look at an approach used in social work that has come to create a template of sorts for how to perform daily tasks: Evidence-based practice (EBP). The broad mass of researchers and professionals in social work agree that EBP serves the common good and that the proven methods included in EBP make social work more individualized. According to
Uppsatsen handlar om den rättsliga regleringen kring den småskaliga vat-tenkraften i Sverige. Uppsatsen beskriver därför till stor del det svenska re-gelverket kring småskalig vattenkraft, samt miljöskyddet för miljön och ekologin i anslutning till den småskaliga vattenkraften. På EU-rättens om-råde finns ett antal rättsakter som på ett mer eller mindre omfattande sätt berör den småskaliga vattenk
Thailand is facing with various extreme climate events from flood to drought. As a result of climate change, these events tend to increase in frequency and intensity. The existing water infrastructures and management is showing sign of fragility and incapable of dealing with these challenges. To increase adaptive capacity and tackle current water resource challenges, water management agencies in T
Incorporating a multi-year grass ley into an arable crop rotation can increase soil organic carbon stocks, reduce carbon emissions and provide feedstock for biogas. This thesis set out to study how a policy promoting agricultural biomass for biogas impacts GHG emissions and carbon sequestration on a regional level over a temporal scale of 20 years. This was done in the specific case of policy prom
Today there are limited theories that consider the research subject relationship creation as a contributing factor to a company’s brand loyalty within an organizational marketing context. The purpose of this thesis is to contribute with knowledge about organizational relationship creation between distributors and retailers, and how these relationships are constructed through communication efforts.
För ca 13 000 år sedan bildades ett skarpt avgränsat mörkare sedimentlager i Barsebäcks mosse, då en sjö, idag ett kärr, i sydvästra Skåne. Detta ”mystiska lager” skiljer sig markant från omgivande lager. Vid tidigare studier samt vid fältkurser med studenter från Lunds universitet har detta mystiska lager dykt upp på några meters djup i borrkärnor. För att lösa mysteriet med hur ”det mystiska lagSediment cores from Barsebäcks mosse, an overgrown lake in southwestern Sweden, display a mysterious sediment layer at a few meters depth. The enigmatic dark-coloured layer is in clear contrast to surrounding light coloured calcareous sediments. A 14C analysis provides an age of 12,760-13,075 cal. yr BP. The dating puts the depositional time to the end of the Late-glacial Allerød warm period. This
