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The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia
Introduction Sweden, as many other high-income countries, has adopted guidelines to offer induction of labour at 41+0 gestational weeks to decrease the risk for perinatal death. As more than 20% of the pregnant population reach this gestational age, and along with other contributing factors, induction rates have increased up to 30% in many countries. Both women and care providers have raised the q
This paper examines the case of Western Sahara through the lens of settler colonial studies. A former Spanish colony in northern Africa, Western Sahara is most often described as ‘occupied’ by Morocco since 1975. I aim at shifting this narrative by applying settler colonial theory, more specifically Veracini’s concept of transfer, to the relation between Moroccan authorities and the indigenous pop
This chapter critically examines a number of ethical dilemmas at stake for professionals working with refugee children and families in Denmark within the field of early childhood education. While national guidelines promote diversity by framing cultural differences as valuable resources, integration policies often result in efforts aimed at assimilation. The chapter explores how everyday ethical j
The research evaluated retrofitting options for a threestory church community building in Grevie, Sweden, assessing the impacts on energy efficiency, life cycle cost, and environmental concerns. An energy model was generated in IDA ICE to simulate the building performance. Various improvements were tested in two separate retrofit package scenarios. They had the following measures in common: the ad
År 2019 introducerade EU det så kallade visselblåsardirektivet. Direktivet tillkom för att komma till rätta med oegentligheter på den inre marknaden och stärka skyddsnivån för visselblåsare. Till följd av direktivets nya krav och bestämmelser behövde samtliga medlemsstater i EU ändra sin nationella lagstiftning på området. Enligt direktivet ska varje rättslig enhet med 50 eller fler arbetstagare hIn 2019, the EU introduced the so-called Whistleblower Directive. The directive was established to address misconduct in the internal market and strengthen the level of protection for whistleblowers. As a result of the directive's new regulations, all EU member states needed to amend their national legislation in this area. According to the directive, every legal entity with 50 or more employe
Detta är både en kvantitativ och en kvalitativ studie av distansundervisningsformen inom Kriminalvårdens Lärcentrummodell. Undersökningen består av en enkätdel, som syftar till att ta reda på de studerandes attityder till undervisningsformen. Det framkommer av sammanställningen att de som har distansundervisning är något mer negativa än de som har lärare på plats. Den andra delen består av statist
Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. To further improve clinical outcome we need new treatment strategies, new prognostic markers, and new treatment predictive factors for personalized medicine.In this dissertation I have focu
High uncertainties are common in detailed quantification of the N budget of agricultural cropping systems. The process-based CoupModel, integrated with the parameter calibration method known as Generalized likelihood uncertainty estimation (GLUE), was used here to define parameter values and estimate an N budget based on experimental data from an organic farming experiment in south-west Sweden. Da
Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a functional
In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not car
The World Health Organization has a standardized tool to assess surgical capacity in low- and middle-income countries (LMICs), but it is often resource- and time-intensive. There currently exists no simple, evidence-based measure of surgical capacity in these settings. The proportion of cesarean deliveries in regard to the total operations (C/O ratio) has been suggested as a way to assess quickly
Abstract The world has seen three industrial revolutions and now it embraces the fourth. The fourth industrial revolution, (globalisation 4.0) or as this study uses industry 4.0, follows onto the third industrial revolution by connecting digital, material and living spheres. The narrative of Africa rising, and the related expansion of mobile phone motivated the thesis interest. As past development
Technological advancements continue to drive changes in our modern society. To keep up with these changes, it is of utter importance to stay competitive, whilst remaining flexible enough to be prepared for future changes. A sector which has struggled in this aspect, traditionally, is self-employed craftsmen - individuals who run a business based upon an aptitude for their trade. This study focuses
Payment for water ecosystem services has been gaining attention in Latin America because of the direct response for environmental conservation through economic mechanisms. By connecting nature services with people who benefit from them, it creates a sustainable intervention for the ecosystem’s management while enhancing human well-being according to policy implementers. Nevertheless, these initiat
