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Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume

BACKGROUND: Changes in Ischemic White matter hyperintensities volume (WMH) on MRI over time are associated with cognitive decline. We investigated whether changes in WMH volume over time exhibit WMH-normalized volume threshold effects on declining cognitive performance and whether these effects on cognition differ between deep white matter hyperintensities (DWMH) and periventricular white matter h

Sex differences in health-related quality of life after renal cell carcinoma surgery : a population-based study in Sweden

PURPOSE: To examine sex differences in health-related quality of life (HRQoL) among patients surgically treated for renal cell carcinoma (RCC) in Sweden, utilizing data from the National Swedish Kidney Cancer Register (NSKCR).METHODS: In this study of 4658 surgically treated RCC patients, data on HRQoL, clinical, demographic, and socioeconomic characteristics were retrieved from the NSKCR for pati

A Feasibility Study of Clinicians’ Perspectives on Relapse Prevention Treatment for Problematic Gaming Among Adolescents

This study evaluated the adaptation of relapse prevention treatment, originally for substance use, to address problematic gaming in children and adolescents. The goal was to understand the feasibility of this treatment in child and adolescent mental health services from the clinicians’ perspective. Six clinicians, four women and two men aged 37–47 with 4–20 years of work experience, were interview

2021. D€ Syllabus (draft)

2021. D€ syllabus (draft) Doctoral School Agenda 2030 Digital Monies for a Sustainable Future (Fall 2021) The syllabus is preliminary and subject to changes till the course’s start. The course is taught mainly online, but ends with a one-and-a-half physical workshop at Lund University. For administrative matters, contact Charlina Lunvald (charlina.lunvald@fek.lu.se). # Session Required readings Se

https://www.sustainability.lu.se/sites/sustainability.lu.se/files/2021-06/2021.%20D%E2%82%AC%20syllabus%20(draft).pdf - 2026-05-29

TEDDY Årsrapport 2024-2025 V.3

1 Årsrapport 2024-2025 TEDDY HAR GÅTT I MÅL ATT SAMLA IN PROVER OCH DATA TEDDY - Omgivningsfaktorer för utveckling av autoimmun (typ 1) diabetes, celiaki och sköldkörtelinflammation hos barn 2 Lina Fransson, Ida Jönsson, Malin Goldman Tsubarah och Åke Lernmark Institutionen för kliniska vetenskaper Malmö, Lunds Universitet, Skånes Universitetssjukhus, Malmö Innehållsförteckning 1. TEDDY-studien –

https://www.teddy.lu.se/sites/teddy.lu.se/files/2026-01/TEDDY%20A%CC%8Arsrapport%202024-2025%20v.3.pdf - 2026-05-29

A community effort to identify and correct mislabeled samples in proteogenomic studies

In a community effort to combat sample mislabeling in multi-omic studies, computational solutions received show a wide range of accuracy. The final collaborative product, COSMO, achieves high performance. Applying COSMO to published datasets demonstrates biological impact of the tool.Sample mislabeling or misannotation has been a long-standing problem in scientific research, particularly prevalent in large-scale, multi-omic studies due to the complexity of multi-omic workflows. There exists an urgent need for implementing quality controls to automatically screen for and correct sample mislabels or misannotations in multi-omic studies. Here, we describe a crowdsourced precision

Cardiac arrest in COVID-19 : characteristics and outcomes of in- and out-of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation

AIM: To study the characteristics and outcome among cardiac arrest cases with COVID-19 and differences between the pre-pandemic and the pandemic period in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). METHOD AND RESULTS: We included all patients reported to the Swedish Registry for Cardiopulmonary Resuscitation from 1 January to 20 July 2020. We defined 16 March 2020

Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients

BACKGROUND: Calprotectin (S100A8/A9) is a pro-inflammatory mediator primarily released from neutrophils. Previous studies have revealed associations between plasma calprotectin, disease severity and in-hospital mortality in unselected COVID-19 patients.OBJECTIVE: We aimed to assess whether plasma calprotectin dynamics during the first week of intensive care are associated with mortality and functi

The added value of abbreviated MRI with UF DCE-MRI and DWI on digital breast tomosynthesis in diagnosing breast lesions

Digital breast tomosynthesis (DBT) has become a standard screening tool for breast cancer. However, its diagnostic performance is still limited compared to contrast-enhanced MRI, especially in women with dense breasts. Ultrafast dynamic contrast-enhanced (UF DCE) MRI and diffusion-weighted imaging (DWI) offer a shorter scanning time than conventional MRI and have shown promise in previous studies.

Balancing innovation, 'ordre public' and morality in human germline editing : A call for more nuanced approaches in patent law

This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t

Rural social movements and sustainable agricultural development in sub-Saharan Africa: towards a collaborative research agenda

Agriculture is key to sustainable development globally – particularly incountries where agriculture both accounts for most of the land use andprovides a livelihood for most of the population. We map out a collaborativeresearch agenda aimed at tackling the urgent but poorly understood issue ofthe role of farmer organisations in overcoming political barriers tosustainable and inclusive agricultural

Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery

Secondary lymphedema (LE) following breast cancer-related surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we aimed to elucidate the transcriptional, metabolomic, and lipidomic signature of the adipose tissue developed due to the surgery-induced LE in short- and long-term LE pati

THE INSTITUTE REPRESENTATION AT THE UNITED NATIONS: HISTORICAL EVOLUTION, LEGAL STATUS AND FEATURES

This article examines the historical genesis, nature, features and international legal status of the Institute representation at the UN, both on the territory of the member states and of the member states to the UN. An attempt was made to reveal the status and characteristics of the offices of both the UN and its specialized agencies. On the basis of the analysis, proposals were made to strengthen

Luminance-Preserving and Temporally Stable Daltonization

We propose a novel, real-time algorithm for recoloring images to improve the experience for a color vision deficient observer. The output is temporally stable and preserves luminance, the most important visual cue. It runs in 0.2 ms per frame on a GPU.

Digital Nomads’ Experiences on the Support of Digital Technologies in Relation to Social Isolation

The paper presents digital nomads’ experiences about the support of digital technologies in relation to social isolation. Despite the abundant access to digital technologies for organizational cooperative purposes, the challenge of social isolation constitutes one of the central concerns in nomadicity practices, affecting employees’ choice of working arrangements. To gain further knowledge on the

Combining histological grade, TILs, and the PD-1/PD-L1 pathway to identify immunogenic tumors and de-escalate radiotherapy in early breast cancer : A secondary analysis of a randomized clinical trial

Background The implementation of immunological biomarkers for radiotherapy (RT) individualization in breast cancer requires consideration of tumor-intrinsic factors. This study aimed to investigate whether the integration of histological grade, tumor-infiltrating lymphocytes (TILs), programmed cell death protein-1 (PD-1), and programmed death ligand-1 (PD-L1) can identify tumors with aggressive ch

Simplified environmental analysis of the long-term performance of wood cladding and decking

The performance of timber in exposed environments is affected by several biotic and abiotic factors. For timber cladding and decking, two important aspects include reduced structural performance due to fungal decay and aesthetical changes resulting from superficial effects such as photodegradation and moulds. Predicting the long-term performance of timber is important because it enables rational m

The Prevalence of mRNA Related Discussions during the Post-COVID-19 Era

Vaccinations are one of the most significant interventions to public health, but vaccine hesitancy and skepticism are raising serious concerns for a portion of the population in many countries, including Sweden. In this study, we use Swedish social media data and structural topic modeling to automatically identify mRNA-vaccine related discussion themes and gain deeper insights into how people's re

Fluorescence depolarization studies of heteroatom-doped CDs

In this work, we exploited time-resolved fluorescence polarization anisotropy (TRFA) to characterize un-doped and doped carbon dots (CDs). The rotational correlation time related to the size of the particle through classical Stokes-Einstein-Debye equation. The TRFA technique applied in this study achieves picoseconds time resolution, which approximately corresponds to the particle size determinati