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The aim of this thesis was to evaluate the role of interatrial conduction defects in the genesis of lone paroxysmal atrial fibrillation (AF) using combined approach of non-invasive signal-averaged P-wave ECG, invasive electrophysiological (EP) studies, anatomical studies and animal experiments. Non-filtered signal-averaged P-wave ECG revealed irregularities in orthogonal P-wave morphology and the
