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Soot, or black carbon (BC), aerosol is a major climate forcer with severe health effects. The impacts depend strongly on particle number concentration, size and mixing state. This work reports on two field campaigns at nearby urban and rural sites, 65gkm apart, in southern Sweden during late summer 2018. BC was measured using a single-particle soot photometer (SP2) and Aethalometers (AE33). Differ
Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 and 18 months after treatment initiation. Methods: ORBIT (online remote behavioural intervention for tics) was a two-arm (1:1 ratio), superiority, sing
Downregulation of the DNA repair protein WD40-encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels as prognostic and predictive markers in the SweBCG91RT trial, in which breast cancer patients were randomized for postoperative radiotherapy. Using tissue microarray and
Nanoplastics have been proven to induce toxicity in diverse organisms, yet their effect on soil microbes like bacteria and fungi remains largely unexplored. In this paper, we used micro-engineered soil models to investigate the effect of polystyrene (PS) nanospheres on Pseudomonas putida and Coprinopsis cinerea. Specifically, we explored the effects of increasing concentrations of 60 nm carboxylat
During the 20th century, a number of actors and institutions set out to develop taxonomies of the Swedish population. This thesis examines the most important social classification system, the social group, which despite its great importance in administrative, scientific, commercial, political and media contexts has received little attention in historical research. Invented by the Central Bureau
A search for events with two displaced vertices from long-lived particle (LLP) pairs using data collected by the ATLAS detector at the LHC is presented. This analysis uses 139 fb-1 of proton-proton collision data at s=13 TeV recorded in 2015-2018. The search employs techniques for reconstructing vertices of LLPs decaying to jets in the muon spectrometer displaced between 3 and 14 m with respect to
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general locomotion activity and climbing ability. In addition, transmission microscopy of dissected skeletal muscles of fluvastatin-treated flies reveals stro
Abstract The aim of this three-year research project is to investigate displacements, i.e. changes in the right to housing and food according to the Swedish Social Service Act between 1982-2018, and its implications for the broader issue of social rights in the welfare state. This is done through the notion of advanced legal practices, which refer to incidents where the dominant current law is con
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β-cells. To identify candidates contributing to T2D pathophysiology, we studied human pancreatic islets from ~300 individuals. We found 395 differentially expressed genes (DEGs) in islets from individuals with T2D, including, to our knowledge, novel (OPRD1, PAX5, TET1) and previously identified (CHL1, GLRA1, IAPP) ca
Epithelioid and spindle cell hemangioma was initially described in 1999 in a series of primary bone tumors and was subsequently suggested by some to represent a variant of epithelioid hemangioma. Here, we studied 18 epithelioid and spindle cell hemangiomas. Nine patients (50%) were male. Age at presentation ranged from 12 to 78 years (median: 38.5 y). Nine patients (50%) had tumor(s) limited to bo
Presentation of a protein antigen to T cells generally requires that the antigen be enzymatically processed into an immunogenic peptide(s). The identification of a protease(s) and its mechanism of action in the proteolysis of such an antigen is therefore a primary goal in the study of antigen processing. We show here that Insulin degrading enzyme (IDE), a neutral thiol metalloendo-proteinase that
In this study, LaBO3 (B = Co, Fe, Cu, Al) perovskite catalysts were introduced for Methanol Steam Reforming (MSR). Results showed that LaCoO3 displayed a 100 % methanol conversion efficiency and a notable hydrogen production rate of 7.86 mol/min/gcat, maintaining stability for more than 40 h at 600 °C. Theoretical computations indicate that the CH3O dehydrogenation to CH2O (a rate-determining proc
In vivo proton magnetic resonance spectroscopy (1H-MRS) data often exhibit baselines or low-amplitude signal variations resulting from residual water, imperfectly suppressed lipids, low-amplitude metabolites not considered for fitting, and other features not represented in a basis set. While multitudinous approaches exist to model these baselines in 1H-MR spectral analysis, many continue to lack s
Microorganisms can be used for production of pharmaceutical substances. With the introduction of gene technology, it is possible to transfer information from one organism to the other, thereby making the receiving organism capable of producing substances that it did not so before. This development is very important for e.g. production of therapeutic proteins However, when using living organisms fo
Searches for the electroweak production of charginos, neutralinos and sleptons in final states characterized by the presence of two leptons (electrons and muons) and missing transverse momentum are performed using 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV recorded with the ATLAS experiment at the Large Hadron Collider. No significant excess beyond Standard Model expectations is
Large igneous provinces (LIPs) are excellent spatial and temporal geological recorders. However, our understanding of LIPs is hindered by a lack of preservation and alteration of many LIPs through deep time. Several LIPs have been emplaced in the Rhyacian. These LIPs demonstrate a connection across the Superior, Wyoming and North Atlantic cratons. In this study we use new U-Pb ID-TIMS baddeleyite
Viral hepatitis remains a global health concern, with growing recognition of the impact of hepatitis A virus (HAV), hepatitis E virus (HEV), and herpesvirus-associated hepatitis, particularly in vulnerable groups. This narrative review from the ESCMID Study Group for Viral Hepatitis (ESGVH) summarizes recent advances and expert perspectives. For HAV, insights into viral evolution, epidemiology, an
Charged Higgs bosons produced either in top-quark decays or in association with a top quark, subsequently decaying via (Formula presented), are searched for in (Formula presented) of proton-proton collision data at (Formula presented) recorded with the ATLAS detector. Depending on whether the top quark is produced together with the (Formula presented) decays hadronically or semileptonically, the s
