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The structural basis for the biological specificity of human cystatin C has been investigated. Cystatin C and other inhibitors belonging to family 2 of the cystatin superfamily interact reversibly with target peptidases, seemingly by independent affinity contributions from a wedge-shaped binding region built from two loop-forming inhibitor segments and a binding region corresponding to the N-termi
The gas phase hydrodeoxygenation of a series of aromatic alcohols, aldehydes and acids has been examined over Ni/SiO2. Compensation behaviour is established with an isokinetic temperature (518 +/- A 21 K) that is consistent with with the point of intersection of the Arrhenius lines. This is accounted for using the Selective Energy Transfer model that is based on resonance between the catalytic Ni-
We previously described a simplified quantitative hemolytic assay for classical pathway (CP) hemolytic function in serum that has been shown to correlate with the 50% hemolytic complement (CH50) assay. In the present study, we used this assay to compare CP functions; plasma levels of C3, C4, and C3dg; and ratios of C3dg to C3 in healthy individuals and patients with systemic lupus erythematosus (S
Background and Objectives. From 1994 to 1997 we conducted a population-based, prospective study on intensive therapy in newly diagnosed symptomatic myeloma patients younger than 60 years, comparing their survival to that of a conventionally treated historic population. Long-term results are presented, including the impact of the degree of response on survival and relapse pattern after transplantat
Purpose: Previously human glandular kallikrein 2 (hK2) has been implicated to predict pathologically organ confined prostate cancer (PCa) in patients with stage T2 disease. Now we evaluated the usefulness of hK2, as measured by 2 entirely different immunoassay designs, to enhance the discrimination of pathologically organ from nonorgan confined clinical stage T1c PCa. Materials and Methods: A cons
This paper compares the extraction effectiveness of six different commonly applied extraction techniques for the determination of PCBs in soil. The techniques included are Soxhlet, Soxtec, ultrasonication extraction, supercritical fluid extraction, microwave-assisted extraction and accelerated solvent extraction. For none of the techniques were the extraction conditions optimized, but instead the
OBJECTIVE:: The aim of the trial was to compare laparoscopic technique with open technique regarding short-term pain, quality of life (QoL), recovery, and complications. BACKGROUND:: Laparoscopic and open techniques for incisional hernia repair are recognized treatment options with pros and cons. METHODS:: Patients from 7 centers with a midline incisional hernia of a maximum width of 10 cm were ra
Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays are being developed for these purposes, it is important to optimize and standardi
Popular Abstract in Swedish Tillväxtfaktorer kan förbättra cellöverlevnad och funktion i djurmodeller av Parkinson’s sjukdom. En av de vanligaste sjukdomarna i nervsystemet är Parkinson’s sjukdom. Den uppkommer genom att man gradvis förlorar en viss grupp av nervceller som använder signalsubstansen dopamin, vilket i sin tur leder till brist på dopamin i målområdet i hjärnan, striatum. Detta resulParkinson’s disease is characterized by progressive degeneration of the nigrostriatal dopamine system, which results in tremor, rigidity, akinesia and postural abnormalities. New therapeutic strategies are aimed at halting the neurodegenerative process or restoring the system by transplantation of fetal dopamine neurons. We have investigated the potential of the neurotrophic factors glial cell lin
Popular Abstract in Swedish Vävnadskallikrein (VK) är ett äggvitespjälkande protein som dels kan aktivera vävnadsnedbrytande enzymer som kollagenas och gelatinas och dels spjälkar kininogen till kininer (bradykinin och kallidin). Via bindning till speciella kininreceptorer (B2 receptorer) som finns överallt i kroppen, styr kininerna olika processer i de flesta av kroppens organ och vävnader såsom Tissue kallikrein releases pharmacollogically highly active kinins from kininogen. Many other enzymes may also release kinins. The aim of the study was to clarify the pathophysiological role of tissue kallikrein in acute pancreatitis. Two sensitive and specific radioimmunoassays for porcine and human tissue kallikrein were developed. A large release of tissue kallikrein from the pancreatic gland
Professorsinstallation LUNDS UNIVERSITET | AULAN | 17 OKTOBER 2014 KL 17.00 Denna broschyr finns på installandis institutioner och kan också beställas från sektionen Kommunikation, tel 046-222 70 10, E-post info@kommunikation.lu.se. Broschyren finns även på www.lu.se/om-universitetet/akademiska-hogtider/professorsinstallationer Produktion Sektionen Kommunikation, Lunds universitet Foto Kennet Ruon
https://www.lu.se/sites/www.lu.se/files/prof-inst_17okt_2014.pdf - 2026-06-23
Popular Abstract in Swedish Avhandlingen undersöker teologen Gustaf Wingrens (1910-2000) kyrkosyn och relaterar den till den nutida diskussionen om Svenska kyrkan som folkkyrka. Tre viktiga frågor ställs till Wingren och andra teologer och debattörer, som ingår i undersökningen, nämligen: Vad är kyrkan? (om kyrkans väsen). Vem är kyrka? (om gränser, medlemskap och auktoritet). Var är kyrkan? (om kThis thesis explores the ecclesiology of the Swedish theologian Gustaf Wingren and discusses the future of the "folk church". Three questions What, Who and Where is the Church? sustain the structure of this investigation. Wingren reflected on issues related to the openness and the identity of the church. His main concern was the interpretation the gospel as the liberating message to the guilt-ridd
Popular Abstract in Swedish Betændelses reaktionen er kroppens svar på en skade eller en infektion. Betændelses reaktionen gør at immunforsvarets celler kaldes til det skadede område (kan ses som den røde varme hævelse omkring et sår) og at eventuelle sygdomsfremkaldende emner identificeres og bekæmpes. På lidt længere sigt, fjernes ødelagt væv og helingen af såret påbegyndes. Når det skadede områThe pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. Since leukotrienes have been shown in increased concentrations in stools of IBD patients we hypothesise that LTD4 can play a role in the deve
Background: Patients with lumbar disc herniation are treated with physiotherapy/medication and some with surgery. However, even after technically successful surgery some develop a failed back syndrome with persistent pain. Our aim was to evaluate the efficacy of epiduroscopy in patients who suffer chronic low back pain and/or radicular pain with or without surgery and the gender difference in outc
The results of a search for the direct pair production of top squarks, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, several energetic jets, and missing transverse momentum are reported. The analysis also targets spin-0 mediator models, where the mediator decays into a pair of dark-matter particles and is produced in association with a pair of top
A search for new phenomena in final states containing an e+e- or μ+μ- pair, jets, and large missing transverse momentum is presented. This analysis makes use of proton–proton collision data with an integrated luminosity of 36.1fb-1, collected during 2015 and 2016 at a centre-of-mass energy s=13TeV with the ATLAS detector at the Large Hadron Collider. The search targets the pair production of super
Flavor-changing neutral currents are not present in the Standard Model at tree level and are suppressed in loop processes by the unitarity of the Cabibbo-Kobayashi-Maskawa matrix; the corresponding rates for top quark decay processes are experimentally unobservable. Extensions of the Standard Model can generate new flavor-changing neutral current processes, leading to signals which, if observed, w
Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for T1D. This study tested whether CBCs were altered in 4- to 12-year-old children without (n = 376) or with one or several IAs against insulin, GAD65, or IA-2 (n =
A search for new charged massive gauge bosons, W′, is performed with the ATLAS detector at the LHC. Data were collected in proton–proton collisions at a center-of-mass energy of s=13 TeV and correspond to an integrated luminosity of 36.1 fb−1. This analysis searches for W′ bosons in the W′→tb¯ decay channel in final states with an electron or muon plus jets. The search covers resonance masses betw
