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Neuroblastoma exhibits two cellular phenotypes: therapy-sensitive adrenergic (ADRN) and therapy-resistant mesenchymal (MES). To understand treatment response, it is important to elucidate how these phenotypes impact the dynamics of cancer cell populations and whether they represent distinct cell types or dynamic cell states. Here, we use an integrated experimental and mathematical modeling approac
Understanding how ecological communities assemble in relation to natural and human-induced environmental changes is critical, particularly for communities of pollinators that deliver essential ecosystem services. Despite widespread attention to interactions between functional traits and community responses to environmental changes, the importance of sensory traits has received little attention. To
The ongoing climate change has been increasingly reflected in climate observations around the world, both in terms of averages and extremes, and attributed to anthropogenic climate forcing. When it comes to changing extremes, attribution to climate change is now especially well-established for heat-related extremes worldwide. Understanding changes in extremes is important for climate adaptation as
The fate of soil organic matter (OM) is determined by its microbial use for growth or respiration. Many environmental factors influence microbial OM use, including the presence of contaminants and toxins in the environment, such as heavy metals. We evaluated short- and long-term responses of microbial processes to metal contamination by estimating biomass concentrations and growth rates of bacteri
BACKGROUND: Finding ways to prolong independence in daily life among older people would be beneficial for both individuals and society. Urban green spaces have been found to improve health, but only a few studies have evaluated the association between urban green spaces and independence in daily life. The aim of this study was to assess the long-term effect of urban green spaces on independence in
Little is known about the fate and uptake of nanoplastics (NPs) in natural ecosystems, mainly due to analytical limitations in measuring NPs in complex environmental matrices. Our aim was to quantitatively assess the transport, fate and biological uptake of NPs in freshwater ecosystems by using replicated wetland mesocosms and gold-doped polystyrene nanoparticles. We showed that 97% of the NPs wer
BACKGROUND: By causing inflammation and tissue damage, neutrophil extracellular traps (NETs) constitute an underlying mechanism of aspiration-induced lung injury, a major factor of the low utilization of donor lungs in lung transplantation (LTx).METHOD: To determine whether NET removal during ex vivo lung perfusion (EVLP) can restore lung function and morphology in aspiration-damaged lungs, gastri
Bioenergy plays a major role in the renewable energy supply and is projected to be an important part of the path towards a decarbonised society. Over the past decade, increasing attention has been given to agricultural bioenergy to act as a multifunctional climate mitigation strategy. Energy crops may mitigate climate change while simultaneously contributing to reducing the negative environmental
BACKGROUND: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this
Although outcomes for newly diagnosed acute myeloid leukaemia (AML) have been incrementally improved over the last decades, management of relapsed and refractory (R/R) AML remains a medical challenge. A curative intent for R/R AML usually involves chemotherapy (with or without targeted therapy) with subsequent consolidation, including allogeneic haematopoietic stem cell transplantation. Despite th
Gold particles are commonly used as catalysts in the vapor-liquid-solid (VLS) growth of GaAs nanowires, but the incorporation of gold into the nanowires can negatively affect their electronic and optical properties. In this work, we investigate the equilibrium concentration of Au in GaAs nanowires using density functional theory calculations combined with thermodynamically assessed chemical potent
We present a quantum repeater protocol for distributing entanglement over long distances, where a dedicated communication stage enables trial rates not limited by the travel time between repeater nodes. To accomplish this, each node contains several qubits that can couple to one single-photon emitter. Photons from the emitters in neighboring nodes generate heralded entanglement between qubits in t
The instability of perovskite interfaces caused by interfacial defects and heterojunction evolution hinders the realization of long-term stable inverse perovskite solar cells (IPSCs). This work reports a strategy for the study of heterojunction evolution, the effects of buried interface and carrier dynamics on the stability of perovskite films and devices in 2D/3D heterojunctions. The emphasis is
Voice problems are common among workers in occupations with high demands on oral communication. For sustaining vocal health, it is important to find efficient ways for how to reduce strain on the voice at work, and one way to do so is optimizing the room acoustics for communication. However, to date we do not know enough about what kind of room acoustic conditions that support voice and speech mos
Agricultural landscapes have changed fast in Europe, which has led to steep declines in farmland biodiversity. While this has differentially impacted “farmland species”, some of these seem to be able to use alternative man-made open habitats in forests, such as forest clear-cuts and powerline rights-of-way. We investigated the use of clear-cuts by two historically declining farmland birds, the Yel
BACKGROUND: In rodents, neurotensin contributes to high fat diet induced obesity by facilitation of intestinal fat absorption. The effect of oral lipid load on plasma proneurotensin and relationship with plasma triglycerides in humans is unknown. AIM: To investigate the acute effects of an oral lipid load on proneurotensin and plasma triglycerides and their interrelationships in healthy individual
No-tillage (NT) practice is extensively adopted with aims to improve soil physical conditions, carbon (C) sequestration and to alleviate greenhouse gases (GHGs) emissions without compromising crop yield. However, the influences of NT on GHGs emissions and crop yields remains inconsistent. A global meta-analysis was performed by using fifty peer-reviewed publications to assess the effectiveness of
BACKGROUND: We explored the association of N-terminal probrain natriuretic peptide (NT-proBNP) with metabolic traits in a bi-ethnic African-Caucasian cohort.METHODS: Baseline examinations of the Sympathetic activity and Ambulatory Blood Pressure in African (SABPA) prospective cohort study were performed between 2008 and 2009, and re-examination after a three-year follow up in South African teacher
