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Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD). Clinical translation of differentiation protocols requires standardization of production procedures, and surface-marker-based cell sorting is considered instrumental for reproducible generation of defined cell products. Here, we demonstrate
Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti
In ESS, a pulsed proton beam of 5 MW mean power will hit a tungsten target to generate neutrons by spallation. The pulses are 2.86 ms long and occur with 14 Hz; the power within a pulse is 125 MW. Only centimeters from the target, the neutrons are moderated by liquid hydrogen in aluminium vessels. The deposited power heats the surrounding structures and fluids which are circulated and cooled. The
Do all humans perceive, think and talk about tree cover (‘forests’) in more or less the same way? International forestry programs frequently seem to operate on the assumption that they do. However, recent advances in the language sciences show that languages vary greatly as to how the landscape domain is lexicalized and grammaticalized. Different languages segment and label the large-scale environ
Background: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases.We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated
Background and Purpose CD40 and CD40 ligand (CD40L) are costimulatory molecules of the tumor necrosis factor receptor superfamily and well known for their involvement in inflammatory diseases: atherosclerotic mouse models with disrupted CD40 signalling develop lesions of reduced size with a more stable plaque profile. This study investigated the potential of plasma and intraplaque levels of CD40 a
Emplacement of the Central Atlantic Magmatic Province (CAMP) is thought to have triggered global environmental changes and the end-Triassic mass extinction (ETE). However, the mechanisms linking volcanism and environmental change are unclear. Here we provide new insight into these linkages by measuring the abundance of both sedimentary five- to six-ring polycyclic aromatic hydrocarbons (PAHs) and
Electric Road Systems (ERS) is an emerging new technology that aim to electrify land transport by supplying electric vehicles (EV) with power. By providing EV's the possibility to charge while driving i.e. dynamic charging the battery size can be greatly decreased compared to a solution with nighttime and fast charging. The evaluation of the potential of ERS has already been published in a number
Understanding the perceptions of young people is a critical issue in the formulation and implementation of climate change mitigation strategies. Based on cognitive hierarchy theory, the present study aims to investigate the factors that motivate or hinder young people’s perception of forestation as a strategy to mitigate climate change in post-conflict Somalia. This study hypothesized a model in w
RATIONALE: Vascular calcification is a prominent feature of late-stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a proteoglycan involved in bone mineralisation, associate with diabetes and CVD. We hypothesised that OMD could be implicated in these diseases via vascular calci
To be an “author” might mean many different things, depending on the context in which the word is used. This thesis explores the EU copyright’s concept of author and how it relates to the everyday digital creativity on the Internet. It invites to consider what EU copyright law might look like if the digital creators which this thesis calls Creative Users were included in the legal system as “autho
Expert-led multicriteria methodologies might have significant improvements in terms of relevance and effectiveness when citizen participation is integrated. This inclusion is especially influential regarding urban revitalization projects (URPs) prioritization, which directly affects the conservation of cultural heritage. The objective is to apply an existing multicriteria methodology for URPs’ pri
Objective: The ideal implant material for the surgical repair of pelvic organ prolapse in women is yet to be found. This retrospective study aims to evaluate a porcine small intestinal submucosa (SIS) graft (Surgisis™). Study design: We reviewed the medical records of women that were operated upon for pelvic organ prolapse using implantation of SIS graft and we examined the short-term complication
Infectious diseases often vary seasonally in a predictable manner, and seasonality may be responsible for geographical differences in prevalence. In temperate regions, vector-borne parasites such as malaria are expected to evolve lower virulence and a time-varying strategy to invest more in transmission when vectors are available. A previous model of seasonal variation of avian malaria described a
Introduction: Understanding how hematopoietic stem- and progenitor cells (HSPCs) are regulated is of central importance for the development of new therapies for blood disorders and for regenerative medicine. Traditionally, however, HSPC regulation has been studied in model systems, and little is known about the situation in vivo in humans. Methods: To learn how HSPCs are regulated under native con
Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison
