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Background: Cerebral ischemia activates both the innate and the adaptive immune response, the latter being activated within days after the stroke onset and triggered by the recognition of foreign antigens. Methods: In this study we have investigated the phenotype of antigen presenting cells and the levels of associated major histocompatibility complex class II (MHC II) molecules in the postischemi

With the exponential growth of the World Wide Web, automated subject classification has become a major research issue. Organizing web pages into a hierarchical structure for subject browsing has been gaining more recognition as an important tool in information-seeking processes.The most frequent approach to automated classification is machine learning. It, however, requires training documents and

Objective: To assess the responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) measure, Hip Disability and Osteoarthritis Outcome Score Physical Function Short Form (HOOS-PS), and the Knee Disability and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) in a pharmacological trial. Methods: Data were obtained from a randomized double-blind trial comparing nap

To update the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk model. A dedicated website collected prospective risk and outcome data on 22 381 consecutive patients undergoing major cardiac surgery in 154 hospitals in 43 countries over a 12-week period (May-July 2010). Completeness and accuracy were validated during data collection using mandatory field entry, error and range

Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variabilit

Objective: With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment,

Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni

PURPOSE: To determine whether long-term treatment with the anti-epileptic drug vigabatrin causes damage to rabbit retina.METHODS: Five rabbits were treated continuously with a daily dose of vigabatrin solution per orally during a period of 1-8 months. Two rabbits receiving water were used as controls. Repeated full-field electroretinograms (every two weeks) were assessed during this period. Vigaba

Aims: The aim of this study was to evaluate the effect of Pelvic Floor Muscle Training (PFMT) in women with urinary incontinence (UI) after ischemic stroke. Materials and Methods: Three hundred and thirty-nine medical records of stroke patients were searched. Twenty-six subjects were randomised to a Treatment Group (14 subjects) or a Control Group (12 subjects) in a single blinded, randomised stud

Objective: To characterise distinctive clinical features of giant prolactinomas in women. Design: A multicentre, retrospective case series and literature review. Methods: We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 mu g/l and identified 19 similar cases from the literature; a gender-based comparison of the frequency and age dis

Background: Tibial osteotomy is a treatment for younger and/or physically active patients suffering from uni-compartmental knee osteoarthritis. The open wedge osteotomy by the hemicallotasis technique includes the use of external fixation. The use of external fixation has several advantages, as early mobilization and the opportunity for optimal correction. However, the hemicallotasis technique has

AIMS: Although childhood obesity is becoming increasingly prevalent, treatment options are limited and the continued development of effective treatment strategies is necessary. It is equally important to explore involvement of other resources in society, such as sports associations. This study was designed to investigate the possibility of reducing the degree of obesity in obese children by focusi

Purpose: To explore the phenomenon of silent dissatisfied customers in an online context. Theoretical perspective: In addition to the strategic brand management a customer perspective is grasped. Furthermore, the study explores areas related to service recovery and consumer behaviour. Methodology: We apply an explorative approach in the form of a case study of silent dissatisfied customers from

Att köpa sexuella tjänster har varit brottsligt i Sverige sedan 1999. Även om kriminaliseringen i förarbetena delvis motiverades med att prostitution är skadligt för individerna som befinner sig i situationen så är det inte, åtminstone inte tydligt, ett brott mot person. Samtidigt finns det personer med erfarenhet av att sälja sex som vittnar om utsatthet och övergrepp inom prostitutionen, något s

Bakgrund - Ambulanssjukvården ska kunna bedriva triagering och avancerad sjukvård i det prehospitala rummet. Detta genom rätt kompetens och medicinteknisk utrustning. Riktlinjerna beskrivs som otillräckliga gentemot de patienter som inte bedöms vara kritiska. Ambulanssjuksköterskans bedömningsprocess beskrivs som olika faser som speglar arbetet före, under och efter mötet med patienten. Vårdande bBackground - In today's society, the ambulance services are expected to perform triage and advanced medical care in the prehospital environment. This is achieved through appropriate competence and medical-technical equipment. Guidelines are described as insufficient towards the patients that are not critically ill. The assessment process of the specialist ambulance nurse is described as comple

Purpose. The emergence of the FinTech phenomenon disrupted the financial status quo and spurred the development of technologies that facilitate the delivery of financial services in a novel and groundbreaking manner. This study aims to trace the impact of founding teams' initial characteristics on future growth. Methodology. Using a dataset of 155 UK-based Fintech firms, this dissertation emp

The purpose of the study is to investigate how the secrecy that prevails between municipalities, more precisely between social administrations, can be an obstacle in the case of a family home placement. Four theories have been used in this study to analyze the results: Michael Lipsky's grassroots bureaucracy, Attachment theory by Bowlby, trauma-informed care by Boswell and Batch, and emotions

Non-state armed groups in Mali have recruited female child soldiers for the past 12 years in its Central and Northern regions. Some of these now-former female child soldiers (FFCS) have given birth to children of these combatants, so-called “Children Born of War” (CBOW). Both mothers and their children may experience sexual (ex. gender-based violence) and violence-related (ex. fear) stigmas in the